Hypopituitarism laboratory findings: Difference between revisions
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==== ACTH reserve: ==== | |||
Patients with intermediate cortisol levels need to be tested for ACTH reserve. There are several tests to check the ACTH reserve. Metyrapone | |||
*Laboratory findings consistent with the diagnosis of hypopituitarism include: | *Laboratory findings consistent with the diagnosis of hypopituitarism include: | ||
{| class="wikitable" | {| class="wikitable" | ||
!Hormonal deficiency | !Hormonal deficiency | ||
!Lab finding | !Lab finding | ||
|- | |- | ||
|ACTH | |ACTH | ||
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|- | |- | ||
|TSH | |TSH | ||
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|- | |- | ||
|Gonadotropins | |Gonadotropins | ||
| | | | ||
|- | |- | ||
|Growth hormone | |Growth hormone | ||
| | | | ||
|- | |- | ||
|Prolactin | |Prolactin | ||
| | | | ||
|- | |- | ||
|ADH | |ADH | ||
| | | | ||
|- | |- | ||
|Oxytocin | |Oxytocin | ||
| | | | ||
|} | |} | ||
Revision as of 17:43, 5 September 2017
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Hypopituitarism Microchapters |
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Diagnosis |
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Treatment |
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Hypopituitarism laboratory findings On the Web |
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American Roentgen Ray Society Images of Hypopituitarism laboratory findings |
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Risk calculators and risk factors for Hypopituitarism laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: {IQ}
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Overview
- An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].
- Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].
- [Test] is usually normal among patients with [disease name].
- Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].
OR
- There are no diagnostic laboratory findings associated with [disease name].
Laboratory Findings
- A subnormal/reduced concentration of pituitary hormones is diagnostic of hypopituitarism.[1]
- Any history of a lesion causing hypopituitarism or a symptom suggestive of hypopituitarism is an indication for testing for hypopituitarism.
Corticotopin:
Basal ACTH secretion:
Normal range of serum cortisol is 5 to 25 mcg/dL (138 to 690 nmol/L). Serum cortisol levels are measured at 8 to 9 am and results are interpreted as follows:
| Serum cortisol | Basal ACTH |
|---|---|
| Low: ≤3 mcg/dL (83 nmol/L) | Cortisol deficiency |
| High: ≥18 mcg/dL (497 nmol/L) | No cortisol deficiency even in times of stress |
| Intermediate: >3 mcg/dL (83 nmol/L)
but <18 mcg/dL (497 nmol/L) |
Needs evaluation for ACTH reserve |
ACTH reserve:
Patients with intermediate cortisol levels need to be tested for ACTH reserve. There are several tests to check the ACTH reserve. Metyrapone
- Laboratory findings consistent with the diagnosis of hypopituitarism include:
| Hormonal deficiency | Lab finding |
|---|---|
| ACTH | |
| TSH | |
| Gonadotropins | |
| Growth hormone | |
| Prolactin | |
| ADH | |
| Oxytocin |
References
- ↑ Fleseriu M, Hashim IA, Karavitaki N, Melmed S, Murad MH, Salvatori R, Samuels MH (2016). "Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline". J. Clin. Endocrinol. Metab. 101 (11): 3888–3921. doi:10.1210/jc.2016-2118. PMID 27736313.