Hypopituitarism history and symptoms: Difference between revisions
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==History== | ==History== | ||
A positive history of head trauma or any mass (adenoma) or a lesion ( such as a sellar lesion) or any symptom related to pituitary hormonal deficiency is suggestive of hypopituitarism. | |||
==Symptoms== | ==Symptoms== | ||
| Line 47: | Line 47: | ||
* Weight loss | * Weight loss | ||
* Chest pain | * Chest pain | ||
* Confusion | * Confusion (hypoglycemia) | ||
|- | |- | ||
|Growth Hormone (GH) | |Growth Hormone (GH) | ||
| Line 53: | Line 53: | ||
* Short stature (In children) | * Short stature (In children) | ||
* Fatigue | * Fatigue | ||
* Increased cardiovascular risk | |||
* Decrease muscle mass | * Decrease muscle mass | ||
* Decrease bone mineral denisty which may lead to osteoporosis<ref name="pmid15001597">{{cite journal| author=Murray RD, Columb B, Adams JE, Shalet SM| title=Low bone mass is an infrequent feature of the adult growth hormone deficiency syndrome in middle-age adults and the elderly. | journal=J Clin Endocrinol Metab | year= 2004 | volume= 89 | issue= 3 | pages= 1124-30 | pmid=15001597 | doi=10.1210/jc.2003-030685 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15001597 }}</ref> | * Decrease bone mineral denisty which may lead to osteoporosis<ref name="pmid15001597">{{cite journal| author=Murray RD, Columb B, Adams JE, Shalet SM| title=Low bone mass is an infrequent feature of the adult growth hormone deficiency syndrome in middle-age adults and the elderly. | journal=J Clin Endocrinol Metab | year= 2004 | volume= 89 | issue= 3 | pages= 1124-30 | pmid=15001597 | doi=10.1210/jc.2003-030685 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15001597 }}</ref> | ||
| Line 61: | Line 62: | ||
|In men: | |In men: | ||
* Loss of libido | * Loss of libido | ||
* | * Erectile dysfunction | ||
* Decrease bone mass | * Decrease bone mass | ||
* | * Reduced energy and vitality | ||
* Infertility | |||
In women:<ref name="pmid12050248">{{cite journal| author=Miller KK, Biller BM, Hier J, Arena E, Klibanski A| title=Androgens and bone density in women with hypopituitarism. | journal=J Clin Endocrinol Metab | year= 2002 | volume= 87 | issue= 6 | pages= 2770-6 | pmid=12050248 | doi=10.1210/jcem.87.6.8557 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12050248 }}</ref> | In women:<ref name="pmid12050248">{{cite journal| author=Miller KK, Biller BM, Hier J, Arena E, Klibanski A| title=Androgens and bone density in women with hypopituitarism. | journal=J Clin Endocrinol Metab | year= 2002 | volume= 87 | issue= 6 | pages= 2770-6 | pmid=12050248 | doi=10.1210/jcem.87.6.8557 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12050248 }}</ref> | ||
* Amenorrhea | * Amenorrhea | ||
* Oligomenorrhea | * Oligomenorrhea | ||
* Dyspareunia | |||
* Loss of libido | * Loss of libido | ||
* | * Infertility | ||
|- | |- | ||
|Thyroid Stimulating Hormone (TSH) | |Thyroid Stimulating Hormone (TSH) | ||
| Line 75: | Line 78: | ||
* Cold intolerance | * Cold intolerance | ||
* Weight gain | * Weight gain | ||
* Dry skin | * Dry skin | ||
* | * Hoarseness | ||
* Edema Depression | |||
* Menorrhagia | |||
* Arthralgia | |||
* Psychomotor retardation | |||
|- | |- | ||
|Prolactin | |Prolactin | ||
| | | | ||
* | * Postpartum lactation failure | ||
|- | |- | ||
| rowspan="2" |'''Posterior pituitary''' | | rowspan="2" |'''Posterior pituitary''' | ||
| Line 92: | Line 99: | ||
| | | | ||
* Polyuria | * Polyuria | ||
* | * Polydipsia | ||
* Nocturia | |||
|} | |} | ||
Revision as of 14:03, 6 September 2017
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Hypopituitarism Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Hypopituitarism history and symptoms On the Web |
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American Roentgen Ray Society Images of Hypopituitarism history and symptoms |
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Risk calculators and risk factors for Hypopituitarism history and symptoms |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]
Overview
History
A positive history of head trauma or any mass (adenoma) or a lesion ( such as a sellar lesion) or any symptom related to pituitary hormonal deficiency is suggestive of hypopituitarism.
Symptoms
Patients of hypopituitarism may be asymptomatic or show symptoms which can be non specific or specific for the deficient hormone.[1]
Non specific symptoms
Patients of hypopituitarism may present with the following symptoms:
| Acute hypopituitarism | Chronic hypopituitarism |
|---|---|
|
Symptoms of deficient hormones
In hypopituitarism, either one of the pituitary gland hormones is decreased or the whole hormones are decreased in case of panhypopituitarism. In this table each hormone deficiency symptoms are listed.[2]
| Pituitary gland | Hormone | Symptoms of deficiency |
|---|---|---|
| Anterior pituitary | Adrenocorticotrophic Hormone (ACTH) | The most critical hormonal deficient in hypopituitarism.[3][4]
|
| Growth Hormone (GH) |
| |
Gonadotropin hormones:
|
In men:
In women:[6]
| |
| Thyroid Stimulating Hormone (TSH) |
| |
| Prolactin |
| |
| Posterior pituitary | Oxytocin |
|
| Anti Diuretic Hormone (ADH |
|
References
- ↑ Ascoli, Paola; Cavagnini, Francesco (2006). "Hypopituitarism". Pituitary. 9 (4): 335–342. doi:10.1007/s11102-006-0416-5. ISSN 1386-341X.
- ↑ Fleseriu, Maria; Hashim, Ibrahim A.; Karavitaki, Niki; Melmed, Shlomo; Murad, M. Hassan; Salvatori, Roberto; Samuels, Mary H. (2016). "Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline". The Journal of Clinical Endocrinology & Metabolism. 101 (11): 3888–3921. doi:10.1210/jc.2016-2118. ISSN 0021-972X.
- ↑ Burke, C.W. (1985). "Adrenocortical insufficiency". Clinics in Endocrinology and Metabolism. 14 (4): 947–976. doi:10.1016/S0300-595X(85)80084-0. ISSN 0300-595X.
- ↑ Bancos I, Hahner S, Tomlinson J, Arlt W (2015). "Diagnosis and management of adrenal insufficiency". Lancet Diabetes Endocrinol. 3 (3): 216–26. doi:10.1016/S2213-8587(14)70142-1. PMID 25098712.
- ↑ Murray RD, Columb B, Adams JE, Shalet SM (2004). "Low bone mass is an infrequent feature of the adult growth hormone deficiency syndrome in middle-age adults and the elderly". J Clin Endocrinol Metab. 89 (3): 1124–30. doi:10.1210/jc.2003-030685. PMID 15001597.
- ↑ Miller KK, Biller BM, Hier J, Arena E, Klibanski A (2002). "Androgens and bone density in women with hypopituitarism". J Clin Endocrinol Metab. 87 (6): 2770–6. doi:10.1210/jcem.87.6.8557. PMID 12050248.