High cholesterol causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamed Moubarak, M.D. [2]

Overview

High cholesterol level can result from various causes which include: genetic (e.g. apo A-I deficiency, apolipoprotein B deficiency, apolipoprotein C2 deficiency, apoliprotein E deficiency, autosomal recessive hypercholesterolemia, familial combined hyperlipidemia, familial hypercholesterolemia); side effect of medications (e.g. antiretroviral therapy, beta blockers, corticosteroids); metabolic (e.g. metabolic syndrome, Niemann-Pick disease type B, obesity, Zieve's syndrome), endocrine (e.g. polycystic ovary syndrome, Werner syndrome) and many other conditions.

Causes

Common Causes

Causes by Organ System

Cardiovascular Alagille syndrome, familial hypercholesterolemia
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect Cyclosporine, estrogens, everolimus, olanzapine, sirolimus, temsirolimus, thiazide diuretics , tofacitinib
Ear Nose Throat No underlying causes
Endocrine Diabetes mellitus, metabolic syndrome, polycystic ovary syndrome,hypothyroidism,
Environmental No underlying causes
Gastroenterologic Glycogenosis type 3, glycogenosis type 6, Niemann-Pick disease type B , primary biliary cirrhosis, Stauffer syndrome, Zieve's syndrome
Genetic Analbuminaemia, apo A-I deficiency, apolipoprotein B deficiency, apolipoprotein C2 deficiency, apoliprotein E deficiency, autosomal recessive hypercholesterolemia, familial combined hyperlipidemia, familial hypercholesterolemia, glycogen storage disease type 1a, glycogenosis type 3, glycogenosis type 6, familial hyperlipoproteinemia type 5, lecithin cholesterol acyltransferase deficiency, lipoprotein lipase deficiency, Niemann-Pick disease type B
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease No underlying causes
Musculoskeletal/Orthopedic Berardinelli–Seip syndrome
Neurologic Apo A-I deficiency, apoliprotein E deficiency
Nutritional/Metabolic Metabolic syndrome, Niemann-Pick disease type B, obesity, Zieve's syndrome,Berardinelli–seip syndrome, analbuminaemia, diabetes mellitus, diabetes mellitus
Obstetric/Gynecologic Polycystic ovary syndrome, pregnancy
Oncologic No underlying causes
Ophthalmologic Alström syndrome
Overdose/Toxicity No underlying causes
Psychiatric Binge eating disorder
Pulmonary No underlying causes
Renal/Electrolyte Chronic kidney disease, nephrotic syndrome
Rheumatology/Immunology/Allergy hashimoto's thyroiditis
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous Lack of physical inactivity |-

Causes in Alphabetical Order

References


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