Low cholesterol causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamed Moubarak, M.D. [2]
Overview
Low cholesterol level can be caused by various factors, with malabsorption and malnutrition being the most common. Genetic, metabolic, liver disease, and drug side effect were also reported to cause low cholesterol level.
Causes
Life Threatening Causes
Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated. Low cholesterol in itself is not a life threatening condition.
Common Causes
- Adrenal insufficiency
- Cachexia
- Celiac disease
- Failure to thrive
- Levothyroxine
- Liver disease
- Malabsorption
- Malnutrition
- Shock
- Statins
Causes by Organ System
| Cardiovascular | Shock |
| Chemical/Poisoning | No underlying causes |
| Dental | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | Levothyroxine, statins |
| Ear Nose Throat | No underlying causes |
| Endocrine | Adrenal insufficiency, hyperthyroidism, levothyroxine |
| Environmental | No underlying causes |
| Gastroenterologic | Failure to thrive, liver disease, malabsorption |
| Genetic | Abetalipoproteinemia , apo A-I deficiency, familial alphalipoprotein deficiency, hypobetalipoproteinemia , Smith-Lemli-Opitz syndrome |
| Hematologic | Beta thalassemia,[1][2] leukemia[3] |
| Iatrogenic | No underlying causes |
| Infectious Disease | Shock |
| Musculoskeletal/Orthopedic | No underlying causes |
| Neurologic | Apo A-I deficiency |
| Nutritional/Metabolic | Cachexia, celiac disease, failure to thrive, hyperthyroidism, malabsorption , malnutrition, Smith-Lemli-Opitz syndrome |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | Leukemia[3] |
| Ophthalmologic | No underlying causes |
| Overdose/Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | No underlying causes |
| Renal/Electrolyte | Manganese deficiency |
| Rheumatology/Immunology/Allergy | Celiac disease |
| Sexual | No underlying causes |
| Trauma | No underlying causes |
| Urologic | No underlying causes |
| Miscellaneous | No underlying causes |
Causes in Alphabetical Order
References
- ↑ 1.0 1.1 Tassiopoulos T, Stamatelos G, Zakopoulos N, Fessas P, Eliopoulos GD (1995). "Low incidence of acute myocardial infarction in beta-thalassaemia trait carriers". Haematologia (Budap). 26 (4): 199–203. PMID 7590514.
- ↑ 2.0 2.1 Maioli M, Pettinato S, Cherchi GM, Giraudi D, Pacifico A, Pupita G; et al. (1989). "Plasma lipids in beta-thalassemia minor". Atherosclerosis. 75 (2–3): 245–8. PMID 2712866.
- ↑ 3.0 3.1 3.2 Pandolfino J, Hakimian D, Rademaker AW, Tallman MS (1997). "Hypocholesterolemia in hairy cell leukemia: a marker for proliferative activity". Am J Hematol. 55 (3): 129–33. PMID 9256291.