Hairy cell leukemia differential diagnosis: Difference between revisions

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Revision as of 11:22, 21 October 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

Hairy cell leukemia must be differentiated from other diseases that cause weight loss, fatigue, splenomegaly, and fever, such as chronic lymphocytic leukaemia, prolymphocytic leukaemia, follicular lymphoma, and mantle cell lymphoma.^[1]

Differenting Hairy cell leukemia from other Diseases

Hairy cell leukemia must be differentiated from other diseases that cause weight loss, fatigue, splenomegaly, and fever, such as chronic lymphocytic leukaemia, prolymphocytic leukaemia, follicular lymphoma, and mantle cell lymphoma.^[1]


Differential Diagnosis	Surface Immunoglobulin	CD5	CD22/FMC7	CD23	CD79b	CD103

Hairy cell leukaemia	Strongly positive	Negative	Positive	Negative	Positive/Negative	Positive
Chronic lymphocytic leukaemia	Weakly positive	Positive	Negative	Positive	Negative	Positive/Negative
Prolymphocytic leukaemia	Strongly positive	Negative	Positive	Negative	Positive	Negative
Mantle cell lymphoma	Positive	Positive	Strongly positive	Negative	Strongly positive	Negative
Follicular lymphoma	Strongly positive	Negative	Positive	Negative	Strongly positive	Negative

Hairy cell leukemia must also be differentiated from other causes of fever, splenomegaly, and fatigue such as:^[2]

Aplastic anemia
Myelodysplastic syndrome
B-cell prolymphocytic leukemia
Idiopathic myelofibrosis

References

↑ ^1.0 ^1.1 Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011
↑ Hairy Cell Leukimea. Wikipedia (2015) https://en.wikipedia.org/wiki/Hairy_cell_leukemia#Pathophysiology Accessed on October ,21 2015

Template:WikiDoc Sources

[H-1] 1.0 ^1.1 Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011

[wiki-2] Hairy Cell Leukimea. Wikipedia (2015) https://en.wikipedia.org/wiki/Hairy_cell_leukemia#Pathophysiology Accessed on October ,21 2015

[1]

[2]

@@ Line 3: / Line 3: @@
 {{CMG}} {{AE}}{{HL}}
 ==Overview==
-* Chronic lymphocytic leukemia must be differentiated from other diseases that cause [[weight loss]],  [[night sweats]], [[hepatosplenomegaly]], and palpable [[lymph node]]s, such as [[hairy cell leukaemia]], prolymphocytic leukaemia, [[follicular lymphoma]], and [[mantle cell lymphoma]].<ref name="H">Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011</ref>
+* Hairy cell leukemia must be differentiated from other diseases that cause [[weight loss]], [[fatigue]], [[splenomegaly]], and fever, such as [[chronic lymphocytic leukaemia]], prolymphocytic leukaemia, [[follicular lymphoma]], and [[mantle cell lymphoma]].<ref name="H">Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011</ref>
-==Differenting Chronic lymphocytic leukemia from other Diseases==
+==Differenting Hairy cell leukemia from other Diseases==
-* Chronic lymphocytic leukemia must be differentiated from other diseases that cause [[weight loss]],  [[night sweats]], [[hepatosplenomegaly]], and palpable [[lymph node]]s, such as [[hairy cell leukaemia]], prolymphocytic leukaemia, [[follicular lymphoma]], and [[mantle cell lymphoma]].
+* Hairy cell leukemia must be differentiated from other diseases that cause [[weight loss]], [[fatigue]], [[splenomegaly]], and fever, such as [[chronic lymphocytic leukaemia]], prolymphocytic leukaemia, [[follicular lymphoma]], and [[mantle cell lymphoma]].<ref name="H">Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011</ref>
-* Based on the expression of cell surface markers, the table below differentiates chronic lymphocytic leukemia from other diseases that cause similar clinical presentations:<ref name="H">Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011</ref>
 <br>
 {| style="border: 0px; font-size: 90%; margin: 3px; width: 1000px"
@@ Line 23: / Line 22: @@
 | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
-'''Chronic lymphocytic leukaemia'''
+'''Hairy cell leukaemia'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center |
+| style="padding: 5px 5px; background: #F5F5F5;" align=center|
-'''Weakly positive'''
+'''Strongly positive'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center |
+| style="padding: 5px 5px; background: #F5F5F5;" align=center|
-'''Positive'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center |
 '''Negative'''
 | style="padding: 5px 5px; background: #F5F5F5;" align=center|
@@ Line 36: / Line 33: @@
 | style="padding: 5px 5px; background: #F5F5F5;" align=center|
 '''Positive/Negative'''
+| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+'''Positive'''
 |-
 | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
-'''Prolymphocytic leukaemia'''
+'''Chronic lymphocytic leukaemia'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+| style="padding: 5px 5px; background: #F5F5F5;" align=center |
-'''Strongly positive'''
+'''Weakly positive'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center|
+| style="padding: 5px 5px; background: #F5F5F5;" align=center |
+'''Positive'''
+| style="padding: 5px 5px; background: #F5F5F5;" align=center |
 '''Negative'''
 | style="padding: 5px 5px; background: #F5F5F5;" align=center|
@@ Line 50: / Line 51: @@
 '''Negative'''
 | style="padding: 5px 5px; background: #F5F5F5;" align=center|
-'''Positive'''
+'''Positive/Negative'''
-| style="padding: 5px 5px; background: #F5F5F5;" align=center|
-'''Negative'''
 |-
 | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
-'''Hairy cell leukaemia'''
+'''Prolymphocytic leukaemia'''
 | style="padding: 5px 5px; background: #F5F5F5;" align=center|
 '''Strongly positive'''
@@ Line 67: / Line 66: @@
 '''Negative'''
 | style="padding: 5px 5px; background: #F5F5F5;" align=center|
-'''Positive/Negative'''
+'''Positive'''
 | style="padding: 5px 5px; background: #F5F5F5;" align=center|
-'''Positive'''
+'''Negative'''
 |-
@@ Line 106: / Line 105: @@
 |}
 <br>
-* Chronic lymphocytic leukemia must also be differentiated from other causes of fever, hepatosplenomegaly, and lymph node swelling such as:<ref name="wiki">Chronic Lymphocytic Leukimea. Wikipedia (2015) https://en.wikipedia.org/wiki/B-cell_chronic_lymphocytic_leukemia Accessed on October ,12 2015</ref>
+* Hairy cell leukemia must also be differentiated from other causes of fever, splenomegaly, and fatigue such as:<ref name="wiki">Hairy Cell Leukimea. Wikipedia (2015) https://en.wikipedia.org/wiki/Hairy_cell_leukemia#Pathophysiology Accessed on October ,21 2015</ref>
-:* [[Splenic marginal zone lymphoma]]
+:* Aplastic anemia
-:* Nodal marginal zone [[lymphoma]]
+:* Myelodysplastic syndrome
-:* [[Lymphoplasmacytic lymphoma]]
+:* B-cell prolymphocytic leukemia
-:* [[Sézary syndrome]]
+:* Idiopathic myelofibrosis
-:* Smoldering [[adult T cell leukemia]]
 ==References==
 {{reflist|2}}

Hairy cell leukemia differential diagnosis: Difference between revisions

Revision as of 11:22, 21 October 2015

Overview

Differenting Hairy cell leukemia from other Diseases

References

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