Esophagitis pathophysiology: Difference between revisions

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__NOTOC__
__NOTOC__
{{Esophagitis}}
{{Esophagitis}}
{{CMG}} {{AE}}
{{CMG}} ; {{AE}} {{Ajay}} ; {{ADG}}


==Overview==
==Overview==
[[Eosinophilic esophagitis]] is an immunoallergic disorder resulting from the interaction between genetics and environmental triggers such as repeated exposure to food and aeroallergens. The [[eosinophils]] are absent in an otherwise normal [[esophagus]], the presence of the [[eosinophils]] in the [[esophagus]] suggests [[GERD]] or [[EoE]]. The documented [[cytokine]] expression profile in the [[esophageal]] [[tissue]] of [[EoE]] patients is that of a [[T helper cell|TH2]] [[inflammatory]] response. [[IL-5]] and [[Interleukin 13|IL-13]] are produced by the type-2 helper T cells ([[Th2]]) in response to the [[antigenic]] [[proteins]] from the [[food]] or [[inhalation]]. [[IL-13]] further stimulates the [[epithelial]] cells of the [[esophagus]] to produce large proteins to induce a gene called eotaxin-3, which in turn recruits [[eosinophils]] from the peripheral blood into the tissue. [[IL-5]] prolongs the survival of the [[eosinophils]]. The activated [[TH2-cells|TH2]] response leads to the recruitment and activation of [[Mast cells]] [[degranulate]] and cause tissue damage and repair. [[Cytokines]] produced by TH-1 cells are [[Tumour necrosis factor|tumor necrosis factor]] (TNF)-α, Interferon (IFN)-γ, [[TNF-α]] is expressed by the [[epithelial cells]] of the [[esophagus]] whereas the INF-γ is upregulated by the [[Peripheral T cells lymphoma|peripheral T cells.]] Delayed or type- IV [[hypersensitivity]] is the mechanism is involved in the [[Eosinophilic esophagitis|EoE]] rather than the non-IgE. It is postulated that the [[EoE]]-defining [[endoscopic]] and [[histologic]] manifestations are a culmination of the disease process which, may have debilitating long-term effects including [[strictures]] and food impactions in untreated or poorly managed cases of [[EoE]]. CD34+ [[myeloid]] precursor cells in the [[bone marrow]] produce [[eosinophils]] and then the [[eosinophils]] develop granulation and migrate to [[vascular]] spaces. The preformed [[granule]] [[proteins]] of the [[eosinophils]] are ECP- Eosinophil Cationic Protein, MBP- [[Major basic protein|Major Basic Protein]], EPO- Eosinophil [[Peroxidase]], EDN- [[Eosinophil]] Derived [[Neurotoxin]]. Upon the stimulation and the degranulation, the [[eosinophils]] release the [[granule]] [[proteins]] into the tissues. [[Eosinophils]] synthesize and release [[cytokines]] such as [[Interleukin 5|IL-5]], [[Interleukin 13|IL-13]], Transforming growth factor (TGF)-α and -β, [[Chemokines]] (eotaxins and RANTES), Lipid mediators such as platelet activating factor ([[PAF]]) and [[leukotriene]] C4. [[Interleukin 5|IL-5]], [[IL-13]], and [[granulocyte]]-[[macrophage]] colony stimulating factor ([[GM-CSF]]) can cause the [[maturation]] and migration of the [[eosinophils]]. [[Eosinophils]] cause [[inflammation]] in the [[EoE]] patients by the following mechanisms [[Angiogenic]] [[molecules]] from the [[eosinophils]] recruits the [[inflammatory]] [[cells]] and the increase the [[vascularity]]. [[Fibrogenic]] [[Mediator|mediators]] such as TGF-β1 and [[matrix]] [[metalloproteinase]] 9 (MMP)-9 causes the [[airway]] remodeling. MBP and MMP-9 disrupt the integrity of the [[epithelial cells]] of the [[esophageal]] through their involvement in [[smooth muscles]], [[fibroblasts]], and [[Cell adhesion molecule|cell-adhesion]] [[molecules]]. The above-mentioned processes lead to tissue remodeling eventually causing an overall [[esophageal]] [[Dysfunctional|dysfunction]].Pathophysiology of reflux esophagitis depends on several mechanisms that lead to the retrograde movement of the acidic content of [[Stomach|the stomach]] to the [[esophagus]]. These mechanisms include transient [[lower esophageal sphincter]] relaxation, hypotensive lower [[esophageal sphincter]], [[Hiatus hernia|hiatal hernia]], and prolonged[[esophageal]] [[acid]] clearance.
The [[esophagus]] is a part of the [[gastrointestinal tract]] which is responsible of moving [[Food|the food]] from the [[mouth]] to the [[rectum]]. Esophagitis is defined as inflammation of [[Mucosal|mucosal layer]] of [[esophagus]]. Based on the etiology of inflammation esophagitis can be classified into reflux esophagitis and eosinophilic esophagitis. Any condition that lead to the [[reflux]] of the [[gastric]] [[acidic]] contents into the [[esophagus]] results in reflux esophagitis. [[Eosinophilic esophagitis]] is an immunoallergic disorder resulting from the interaction between genetics and environmental triggers such as repeated exposure to food and aeroallergens. [[T helper cell|TH2]] [[inflammatory]] cell response play a major role in the production of eosinophils. Activated [[TH2-cells|TH2]] response leads to the recruitment and activation of eosinophils and mast cells. Characteristic gross pathology findings of esophagitis include fixed [[esophageal]] ring, white [[exudate]]<nowiki/>s, longitudinal furrows/ fibrosis, [[Mucous membrane|mucosal]] [[pallor]], [[Diffuse]] [[esophageal]] narrowing. Characteristic microscopic findings  of esophagitis include edema and basal [[hyperplasia]] (non-specific [[inflammatory]] changes), lymphocytic infiltration, [[Neutrophilia|neutrophilic]] [[inflammation|infiltration,]] eosinophilic [[inflammation|infiltration,]] goblet cell [[intestinal]] [[metaplasia]] or [[Barrett's esophagus]] and elongation of the [[papillae]].


==Pathophysiology==
==Pathophysiology==
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* The [[lower esophageal sphincter]] is contracting [[smooth muscle]] at the end of the [[esophagus]] responsible for the food passage to the [[stomach]]. LES has high pressure tone which helps keeping it a strong barrier between the [[esophagus]] and the [[stomach]].
* The [[lower esophageal sphincter]] is contracting [[smooth muscle]] at the end of the [[esophagus]] responsible for the food passage to the [[stomach]]. LES has high pressure tone which helps keeping it a strong barrier between the [[esophagus]] and the [[stomach]].


[[Image:GERD.png|350px|thumb|center|Source by:BruceBlaus - Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=44923646|]]
[[Image:GERD.png|350px|thumb|center|Source by:BruceBlaus - Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=44923646]]


===Reflux Esophagitis===
=== '''Pathogenesis''' ===
Esophagitis is defined as inflammation of mucosal layer of esophagus. Based on the etiology of inflammation esophagitis can be discussed under two categories
* Reflux esophagitis
* Eosinophilic esophagitis
 
====Reflux Esophagitis====
Pathogenesis of reflux esophagitis depends on various mechanisms that lead to the [[reflux]] of the [[gastric]] [[acidic]] contents into the [[esophagus]]. Several mechanisms impair the anti-reflux barrier and cause [[esophageal dysmotility]]. These mechanisms include the following:<ref name="pmid11060472">{{cite journal| author=Storr M, Meining A, Allescher HD| title=Pathophysiology and pharmacological treatment of gastroesophageal reflux disease. | journal=Dig Dis | year= 2000 | volume= 18 | issue= 2 | pages= 93-102 | pmid=11060472 | doi=10.1159/000016970 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11060472  }}</ref><ref name="pmid17345925">{{cite journal| author=De Giorgi F, Palmiero M, Esposito I, Mosca F, Cuomo R| title=Pathophysiology of gastro-oesophageal reflux disease. | journal=Acta Otorhinolaryngol Ital | year= 2006 | volume= 26 | issue= 5 | pages= 241-6 | pmid=17345925 | doi= | pmc=2639970 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17345925  }}</ref>
Pathogenesis of reflux esophagitis depends on various mechanisms that lead to the [[reflux]] of the [[gastric]] [[acidic]] contents into the [[esophagus]]. Several mechanisms impair the anti-reflux barrier and cause [[esophageal dysmotility]]. These mechanisms include the following:<ref name="pmid11060472">{{cite journal| author=Storr M, Meining A, Allescher HD| title=Pathophysiology and pharmacological treatment of gastroesophageal reflux disease. | journal=Dig Dis | year= 2000 | volume= 18 | issue= 2 | pages= 93-102 | pmid=11060472 | doi=10.1159/000016970 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11060472  }}</ref><ref name="pmid17345925">{{cite journal| author=De Giorgi F, Palmiero M, Esposito I, Mosca F, Cuomo R| title=Pathophysiology of gastro-oesophageal reflux disease. | journal=Acta Otorhinolaryngol Ital | year= 2006 | volume= 26 | issue= 5 | pages= 241-6 | pmid=17345925 | doi= | pmc=2639970 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17345925  }}</ref>
* Transient [[lower esophageal sphincter]] [[Relaxation|relaxations]] <ref name="pmid10573376">{{cite journal| author=Fisher BL, Pennathur A, Mutnick JL, Little AG| title=Obesity correlates with gastroesophageal reflux. | journal=Dig Dis Sci | year= 1999 | volume= 44 | issue= 11 | pages= 2290-4 | pmid=10573376 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10573376  }}</ref><ref name="pmid10734020">{{cite journal| author=Kahrilas PJ, Shi G, Manka M, Joehl RJ| title=Increased frequency of transient lower esophageal sphincter relaxation induced by gastric distention in reflux patients with hiatal hernia. | journal=Gastroenterology | year= 2000 | volume= 118 | issue= 4 | pages= 688-95 | pmid=10734020 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10734020  }}</ref>  
* Transient [[lower esophageal sphincter]] [[Relaxation|relaxations]] <ref name="pmid10573376">{{cite journal| author=Fisher BL, Pennathur A, Mutnick JL, Little AG| title=Obesity correlates with gastroesophageal reflux. | journal=Dig Dis Sci | year= 1999 | volume= 44 | issue= 11 | pages= 2290-4 | pmid=10573376 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10573376  }}</ref><ref name="pmid10734020">{{cite journal| author=Kahrilas PJ, Shi G, Manka M, Joehl RJ| title=Increased frequency of transient lower esophageal sphincter relaxation induced by gastric distention in reflux patients with hiatal hernia. | journal=Gastroenterology | year= 2000 | volume= 118 | issue= 4 | pages= 688-95 | pmid=10734020 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10734020  }}</ref>  
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* [[Delayed gastric emptying]]
* [[Delayed gastric emptying]]


===Eosinophilic Esophagitis===
====Eosinophilic Esophagitis====
[[Eosinophilic esophagitis]] is an immunoallergic disorder resulting from the interaction between genetics and environmental triggers such as repeated exposure to food and aeroallergens. The [[pathophysiology]] of the EoE is as follows:<ref name="pmid25499460">{{cite journal |vauthors=Malhotra N, Levine J |title=Eosinophilic esophagitis: an autoimmune esophageal disorder |journal=Curr Probl Pediatr Adolesc Health Care |volume=44 |issue=11 |pages=335–40 |year=2014 |pmid=25499460 |doi=10.1016/j.cppeds.2014.10.004 |url=}}</ref><ref name="pmid26051952">{{cite journal |vauthors=Martin LJ, Franciosi JP, Collins MH, Abonia JP, Lee JJ, Hommel KA, Varni JW, Grotjan JT, Eby M, He H, Marsolo K, Putnam PE, Garza JM, Kaul A, Wen T, Rothenberg ME |title=Pediatric Eosinophilic Esophagitis Symptom Scores (PEESS v2.0) identify histologic and molecular correlates of the key clinical features of disease |journal=J. Allergy Clin. Immunol. |volume=135 |issue=6 |pages=1519–28.e8 |year=2015 |pmid=26051952 |pmc=4460579 |doi=10.1016/j.jaci.2015.03.004 |url=}}</ref><ref name="pmid25216976">{{cite journal |vauthors=Lucendo AJ, Arias A, Tenias JM |title=Relation between eosinophilic esophagitis and oral immunotherapy for food allergy: a systematic review with meta-analysis |journal=Ann. Allergy Asthma Immunol. |volume=113 |issue=6 |pages=624–9 |year=2014 |pmid=25216976 |doi=10.1016/j.anai.2014.08.004 |url=}}</ref><ref name="pmid22939463">{{cite journal |vauthors=López-Colombo A |title=[Eosinophilic esophagitis] |language=Spanish; Castilian |journal=Rev Gastroenterol Mex |volume=77 Suppl 1 |issue= |pages=1–3 |year=2012 |pmid=22939463 |doi=10.1016/j.rgmx.2012.07.002 |url=}}</ref><ref name="pmid24117638">{{cite journal |vauthors=Chehade M, Lucendo AJ, Achem SR, Souza RF |title=Causes, evaluation, and consequences of eosinophilic esophagitis |journal=Ann. N. Y. Acad. Sci. |volume=1300 |issue= |pages=110–8 |year=2013 |pmid=24117638 |doi=10.1111/nyas.12243 |url=}}</ref><ref name="pmid23797116">{{cite journal |vauthors=Straumann A |title=Eosinophilic esophagitis: a bulk of mysteries |journal=Dig Dis |volume=31 |issue=1 |pages=6–9 |year=2013 |pmid=23797116 |doi=10.1159/000347095 |url=}}</ref><ref name="pmid22307811">{{cite journal |vauthors=Straumann A |title=Eosinophilic esophagitis: rapidly emerging disorder |journal=Swiss Med Wkly |volume=142 |issue= |pages=w13513 |year=2012 |pmid=22307811 |doi=10.4414/smw.2012.13513 |url=}}</ref><ref name="pmid21429051">{{cite journal |vauthors=Schoepfer AM, Simon D, Straumann A |title=Eosinophilic oesophagitis: latest intelligence |journal=Clin. Exp. Allergy |volume=41 |issue=5 |pages=630–9 |year=2011 |pmid=21429051 |doi=10.1111/j.1365-2222.2011.03739.x |url=}}</ref><ref name="pmid21987875">{{cite journal |vauthors=Godat S, Moradpour D, Schoepfer A |title=[Eosinophilic esophagitis: update 2011] |language=French |journal=Rev Med Suisse |volume=7 |issue=307 |pages=1678–80, 1682 |year=2011 |pmid=21987875 |doi= |url=}}</ref><ref name="pmid14997131">{{cite journal |vauthors=Potter JW, Saeian K, Staff D, Massey BT, Komorowski RA, Shaker R, Hogan WJ |title=Eosinophilic esophagitis in adults: an emerging problem with unique esophageal features |journal=Gastrointest. Endosc. |volume=59 |issue=3 |pages=355–61 |year=2004 |pmid=14997131 |doi= |url=}}</ref>
[[Eosinophilic esophagitis]] is an immunoallergic disorder resulting from the interaction between genetics and environmental triggers such as repeated exposure to food and aeroallergens. The [[pathophysiology]] of the EoE is as follows:<ref name="pmid25499460">{{cite journal |vauthors=Malhotra N, Levine J |title=Eosinophilic esophagitis: an autoimmune esophageal disorder |journal=Curr Probl Pediatr Adolesc Health Care |volume=44 |issue=11 |pages=335–40 |year=2014 |pmid=25499460 |doi=10.1016/j.cppeds.2014.10.004 |url=}}</ref><ref name="pmid26051952">{{cite journal |vauthors=Martin LJ, Franciosi JP, Collins MH, Abonia JP, Lee JJ, Hommel KA, Varni JW, Grotjan JT, Eby M, He H, Marsolo K, Putnam PE, Garza JM, Kaul A, Wen T, Rothenberg ME |title=Pediatric Eosinophilic Esophagitis Symptom Scores (PEESS v2.0) identify histologic and molecular correlates of the key clinical features of disease |journal=J. Allergy Clin. Immunol. |volume=135 |issue=6 |pages=1519–28.e8 |year=2015 |pmid=26051952 |pmc=4460579 |doi=10.1016/j.jaci.2015.03.004 |url=}}</ref><ref name="pmid25216976">{{cite journal |vauthors=Lucendo AJ, Arias A, Tenias JM |title=Relation between eosinophilic esophagitis and oral immunotherapy for food allergy: a systematic review with meta-analysis |journal=Ann. Allergy Asthma Immunol. |volume=113 |issue=6 |pages=624–9 |year=2014 |pmid=25216976 |doi=10.1016/j.anai.2014.08.004 |url=}}</ref><ref name="pmid22939463">{{cite journal |vauthors=López-Colombo A |title=[Eosinophilic esophagitis] |language=Spanish; Castilian |journal=Rev Gastroenterol Mex |volume=77 Suppl 1 |issue= |pages=1–3 |year=2012 |pmid=22939463 |doi=10.1016/j.rgmx.2012.07.002 |url=}}</ref><ref name="pmid24117638">{{cite journal |vauthors=Chehade M, Lucendo AJ, Achem SR, Souza RF |title=Causes, evaluation, and consequences of eosinophilic esophagitis |journal=Ann. N. Y. Acad. Sci. |volume=1300 |issue= |pages=110–8 |year=2013 |pmid=24117638 |doi=10.1111/nyas.12243 |url=}}</ref><ref name="pmid23797116">{{cite journal |vauthors=Straumann A |title=Eosinophilic esophagitis: a bulk of mysteries |journal=Dig Dis |volume=31 |issue=1 |pages=6–9 |year=2013 |pmid=23797116 |doi=10.1159/000347095 |url=}}</ref><ref name="pmid22307811">{{cite journal |vauthors=Straumann A |title=Eosinophilic esophagitis: rapidly emerging disorder |journal=Swiss Med Wkly |volume=142 |issue= |pages=w13513 |year=2012 |pmid=22307811 |doi=10.4414/smw.2012.13513 |url=}}</ref><ref name="pmid21429051">{{cite journal |vauthors=Schoepfer AM, Simon D, Straumann A |title=Eosinophilic oesophagitis: latest intelligence |journal=Clin. Exp. Allergy |volume=41 |issue=5 |pages=630–9 |year=2011 |pmid=21429051 |doi=10.1111/j.1365-2222.2011.03739.x |url=}}</ref><ref name="pmid21987875">{{cite journal |vauthors=Godat S, Moradpour D, Schoepfer A |title=[Eosinophilic esophagitis: update 2011] |language=French |journal=Rev Med Suisse |volume=7 |issue=307 |pages=1678–80, 1682 |year=2011 |pmid=21987875 |doi= |url=}}</ref><ref name="pmid14997131">{{cite journal |vauthors=Potter JW, Saeian K, Staff D, Massey BT, Komorowski RA, Shaker R, Hogan WJ |title=Eosinophilic esophagitis in adults: an emerging problem with unique esophageal features |journal=Gastrointest. Endosc. |volume=59 |issue=3 |pages=355–61 |year=2004 |pmid=14997131 |doi= |url=}}</ref>
* The [[eosinophils]] are absent in an otherwise normal [[esophagus]], the presence of the [[eosinophils]] in the [[esophagus]] suggests [[GERD]] or EoE.
* The [[eosinophils]] are absent in an otherwise normal [[esophagus]], the presence of the [[eosinophils]] in the [[esophagus]] suggests [[GERD]] or EoE.
*They tend to be present in all layers of the [[esophagus]] in EoE, but predominate in the [[lamina propria]] and [[Submucosa|submucosal]] regions.  
*They tend to be present in all layers of the [[esophagus]] in EoE, but predominate in the [[lamina propria]] and [[Submucosa|submucosal]] regions.  
'''Production of eosinophils'''
 
* [[T helper cell|TH2]] [[inflammatory]] response in response to the [[antigenic]] [[proteins]] from the [[food]] or [[inhalation]] is mainly responsible for the production of eosinophils.
===== '''Production of eosinophils''' =====
* [[IL-5]] and [[Interleukin 13|IL-13]] are produced by the type-2 helper T cells ([[Th2]]) stimulation.  
* [[T helper cell|TH2]] [[inflammatory]] cell response play a major role in the production of eosinophils.
* [[IL-13]] further stimulates the [[epithelial]] cells of the [[esophagus]] to induce a gene called eotaxin-3, which in turn recruits [[eosinophils]] from the peripheral blood into the tissue.  
* Activated [[TH2-cells|TH2]] response leads to the recruitment and activation of eosinophils and mast cells.
* T cells ([[Th2]]) cell response also stimulates production of [[IL-5]] and [[Interleukin 13|IL-13]].  
* [[IL-13]] stimulates the [[epithelial]] cells of the [[esophagus]] to induce a gene called eotaxin-3, which in turn recruits [[eosinophils]] from the peripheral blood into the tissue.  
* [[IL-5]] prolongs the survival of the [[eosinophils]].
* [[IL-5]] prolongs the survival of the [[eosinophils]].
*The activated [[TH2-cells|TH2]] response leads to the recruitment and activation of
{| class="wikitable"
** '''[[Eosinophils]]'''
! colspan="2" |Granule [[proteins]] of the [[eosinophils]]
** '''[[Mast cells]]'''
|-
* [[Mast cells]] [[degranulate]] and cause tissue damage and repair.
|'''ECP'''
* [[Cytokines]] produced by TH-1 cells are
|Eosinophil Cationic Protein
** '''[[Tumour necrosis factor|Tumor necrosis factor]] (TNF)-α'''
|-
** '''[[Interferon-gamma|Interferon (IFN)-γ]]'''
|'''MBP'''
* [[TNF-α]] is expressed by the [[epithelial cells]] of the [[esophagus]] whereas [[Interferon-gamma|INF-γ]] is upregulated by the [[Peripheral T cells lymphoma|peripheral T cells.]]
|[[Major basic protein|Major Basic Protein]]
* Delayed or type- IV [[hypersensitivity]] is the mechanism is involved in the EoE.
|-
*It is postulated that the EoE-defining [[endoscopic]] and [[histologic]] manifestations are a culmination of the disease process which, may have debilitating long-term effects including [[strictures]] and food impactions in untreated or poorly managed cases of EoE.
|'''EPO'''
* The preformed [[granule]] [[proteins]] of the [[eosinophils]] are
|Eosinophil [[Peroxidase]]
**'''ECP'''- Eosinophil Cationic Protein
|-
**'''MBP'''- [[Major basic protein|Major Basic Protein]]
|'''EDN'''
**'''EPO'''- Eosinophil [[Peroxidase]]
|[[Eosinophil]] Derived [[Neurotoxin]]
**'''EDN'''- [[Eosinophil]] Derived [[Neurotoxin]]
|}
* Upon the stimulation and the degranulation, the [[eosinophils]] release the [[granule]] [[proteins]] into the tissues.
* [[Eosinophils]] synthesize and release [[cytokines]] such as
**'''[[Interleukin 5|IL-5]]'''
**'''[[Interleukin 13|IL-13]]'''  
**'''[[Transforming growth factor]] [[TGF alpha|(TGF)-α]] and [[TGF beta|-β]]'''
**'''[[Chemokines]] (eotaxins and RANTES)'''
**'''Lipid mediators such as platelet activating factor ([[PAF]]) and [[leukotriene]] C4'''
* [[Interleukin 5|IL-5]], [[IL-13]], and [[granulocyte]]-[[macrophage]] colony stimulating factor ([[GM-CSF]]) can cause the [[maturation]] and migration of the [[eosinophils]].
 
* [[Eosinophils]] cause [[inflammation]] in the EoE patients by the following mechanisms
** [[Eosinophils]] recruits the [[inflammatory]] [[cells]] and increase the [[vascularity]].
** Increased vascularity stimulates fibrogenic [[Mediator|mediators]] such as [[TGF beta|TGF-β1]] and [[matrix]] [[metalloproteinase]] 9 (MMP)-9.
** [[TGF-β]] and [[eosinophilic]] [[granule]] [[proteins]] MBP and EPO are the key [[eosinophil]] [[Effector cell|effector]] [[proteins]].
** MBP and MMP-9 disrupt the integrity of the [[epithelial cells]] of the [[esophageal|esophagus]] through their involvement in the [[smooth muscles]], [[fibroblasts]], and [[Cell adhesion molecule|cell-adhesion]] [[molecules]].
** Eventually resulting in tissue remodeling and [[esophageal]] [[Dysfunctional|dysfunction]].


===Gross Pathology===
===== Role of eosinophils in inflammation =====
*[[Mucosal]] [[biopsies]] of the [[esophagus]] should be obtained in all patients in whom EoE is a clinical possibility regardless of the [[Endoscopy|endoscopic]] appearance.
[[Eosinophils]] cause [[inflammation]] in the EoE patients by the following mechanisms
*[[Endoscopic]] [[abnormalities]] in patients with EoE are as follows:<ref name="urlTable 3: Proposed classification and grading system for the endoscopic assessment of the esophageal features of eosinophilic esophagitis (<a id=ref-link-section-1 title= href=/articles/#ref44">44</a>)">{{cite web |url=https://www.nature.com/articles/ajg201371/tables/3 |title=Table 3: Proposed classification and grading system for the endoscopic assessment of the esophageal features of eosinophilic esophagitis (<a id=ref-link-section-1 title="" href=/articles/#ref44>44</a>) |format= |work= |accessdate=}}</ref><ref name="urlVertical lines in distal esophageal mucosa (VLEM): a true endoscopic manifestation of esophagitis in children? - PubMed - NCBI">{{cite web |url=https://www.ncbi.nlm.nih.gov/pubmed/9199905?dopt=Abstract&holding=npg |title=Vertical lines in distal esophageal mucosa (VLEM): a true endoscopic manifestation of esophagitis in children? - PubMed - NCBI |format= |work= |accessdate=}}</ref><ref name="urlFragility of the esophageal mucosa: a pathognomonic endoscopic sign of primary eosinophilic esophagitis? - PubMed - NCBI">{{cite web |url=https://www.ncbi.nlm.nih.gov/pubmed/12612531?dopt=Abstract&holding=npg |title=Fragility of the esophageal mucosa: a pathognomonic endoscopic sign of primary eosinophilic esophagitis? - PubMed - NCBI |format= |work= |accessdate=}}</ref><ref name="urlEosinophilic esophagitis: red on microscopy, white on endoscopy. - PubMed - NCBI">{{cite web |url=https://www.ncbi.nlm.nih.gov/pubmed/15383737?dopt=Abstract&holding=npg |title=Eosinophilic esophagitis: red on microscopy, white on endoscopy. - PubMed - NCBI |format= |work= |accessdate=}}</ref><ref name="urlThe prevalence and diagnostic utility of endoscopic features of eosinophilic esophagitis: a meta-analysis. - PubMed - NCBI">{{cite web |url=https://www.ncbi.nlm.nih.gov/pubmed/22610003?dopt=Abstract&holding=npg |title=The prevalence and diagnostic utility of endoscopic features of eosinophilic esophagitis: a meta-analysis. - PubMed - NCBI |format= |work= |accessdate=}}</ref>
* Upon the stimulation and the degranulation, the [[eosinophils]] release the [[granule]] [[proteins]] into the tissues.
**Fixed [[esophageal]] ring which is corrugated
* Granule proteins from eosinophils recruits the [[inflammatory]] [[cells]] and increase the [[vascularity]].
**White [[exudate]]  
* Increased vascularity stimulates fibrogenic [[Mediator|mediators]] such as [[TGF beta|TGF-β1]] and [[matrix]] [[metalloproteinase]] 9 (MMP)-9.
**Longitudinal furrows  
* [[TGF-β]] and [[eosinophilic]] [[granule]] [[proteins]] MBP and EPO are the key [[eosinophil]] [[Effector cell|effector]] [[proteins]].
* MBP and MMP-9 disrupt the integrity of the [[epithelial cells]] of the [[esophageal|esophagus]] through their involvement in the [[smooth muscles]], [[fibroblasts]], and [[Cell adhesion molecule|cell-adhesion]] [[molecules]].
* Eventually resulting in tissue remodeling and [[esophageal]] [[Dysfunctional|dysfunction]].  
==Gross Pathology==
*[[Endoscopic]] [[abnormalities]] in patients with esophagitis are as follows:<ref name="urlTable 3: Proposed classification and grading system for the endoscopic assessment of the esophageal features of eosinophilic esophagitis (<a id=ref-link-section-1 title= href=/articles/#ref44">44</a>)">{{cite web |url=https://www.nature.com/articles/ajg201371/tables/3 |title=Table 3: Proposed classification and grading system for the endoscopic assessment of the esophageal features of eosinophilic esophagitis (<a id=ref-link-section-1 title="" href=/articles/#ref44>44</a>) |format= |work= |accessdate=}}</ref><ref name="urlVertical lines in distal esophageal mucosa (VLEM): a true endoscopic manifestation of esophagitis in children? - PubMed - NCBI">{{cite web |url=https://www.ncbi.nlm.nih.gov/pubmed/9199905?dopt=Abstract&holding=npg |title=Vertical lines in distal esophageal mucosa (VLEM): a true endoscopic manifestation of esophagitis in children? - PubMed - NCBI |format= |work= |accessdate=}}</ref><ref name="urlFragility of the esophageal mucosa: a pathognomonic endoscopic sign of primary eosinophilic esophagitis? - PubMed - NCBI">{{cite web |url=https://www.ncbi.nlm.nih.gov/pubmed/12612531?dopt=Abstract&holding=npg |title=Fragility of the esophageal mucosa: a pathognomonic endoscopic sign of primary eosinophilic esophagitis? - PubMed - NCBI |format= |work= |accessdate=}}</ref><ref name="urlEosinophilic esophagitis: red on microscopy, white on endoscopy. - PubMed - NCBI">{{cite web |url=https://www.ncbi.nlm.nih.gov/pubmed/15383737?dopt=Abstract&holding=npg |title=Eosinophilic esophagitis: red on microscopy, white on endoscopy. - PubMed - NCBI |format= |work= |accessdate=}}</ref><ref name="urlThe prevalence and diagnostic utility of endoscopic features of eosinophilic esophagitis: a meta-analysis. - PubMed - NCBI">{{cite web |url=https://www.ncbi.nlm.nih.gov/pubmed/22610003?dopt=Abstract&holding=npg |title=The prevalence and diagnostic utility of endoscopic features of eosinophilic esophagitis: a meta-analysis. - PubMed - NCBI |format= |work= |accessdate=}}</ref>
**Fixed [[esophageal]] ring  
**White [[exudate]]<nowiki/>s
**Longitudinal furrows/ fibrosis
**[[Mucous membrane|Mucosal]] [[pallor]]  
**[[Mucous membrane|Mucosal]] [[pallor]]  
**[[Diffuse]] [[esophageal]] narrowing  
**[[Diffuse]] [[esophageal]] narrowing  
**[[Mucosal]] fragility leading to [[esophageal]] lacerations during the endoscopy  
**[[Mucosal]] fragility leading to [[esophageal]] lacerations during the endoscopy  
*However, because these [[Endoscopy|endoscopic]] features have been described in other [[esophageal]] [[disorders]], none can be considered [[pathognomonic]] for EoE.
*However, because these [[Endoscopy|endoscopic]] features have been described in other [[esophageal]] [[disorders]], none can be considered [[pathognomonic]] for esophagitis.


<gallery>
== Histopathology ==
File:Eosinophilic esophagitis endo.jpg|Endoscopy of the esophagus: Eosinophilic esophagitis <br> Source: Wikimedia
On histopathological analysis, based on the type of esophagitis microscopic findings include:<ref>[http://www.peir.net Images courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology]</ref>
</gallery>
*'''Eosinophilic esophagitis'''
 
 
===Histopathology===
*Characteristic features are as follows:
**> 20 eosinophils/0.24 mm2.  
**> 20 eosinophils/0.24 mm2.  
**Papillae are elongated
**Papillae are elongated
Line 86: Line 81:


[[Image:Eosinophilic esophagiits path.jpg|thumb|center|150px|[[H&E]] stain of [[esophagus]] [[biopsy]] showing eosinophilic esophagitis, manifested by an infiltration of [[eosinophils]] in the [[lamina propria]]]]
[[Image:Eosinophilic esophagiits path.jpg|thumb|center|150px|[[H&E]] stain of [[esophagus]] [[biopsy]] showing eosinophilic esophagitis, manifested by an infiltration of [[eosinophils]] in the [[lamina propria]]]]
* '''Reflux esophagitis'''
**[[Edema]] and basal [[hyperplasia]] (non-specific [[inflammatory]] changes)
**[[Lymphocytic]] infiltration (non-specific)
**[[Neutrophilia|Neutrophilic]] [[inflammation|infiltration]]
**[[Eosinophilic]] [[inflammation|infiltration]] 
**[[Goblet cell]] [[intestinal]] [[metaplasia]] or [[Barrett's esophagus]].
**Elongation of the [[papillae]]
**Thinning of the [[squamous cell]] layer
**[[Dysplasia]] or [[pre-cancer]].




* The most common cause is [[gastroesophageal reflux disease]] ([[GERD]]). If caused by [[GERD]], the diseases is also called [[reflux esophagitis]].
* Other causes of [[esophagitis]] include infections (most commonly [[Candida (genus)|candida]], [[herpes simplex]] and [[cytomegalovirus]]). These infections are typically seen in [[immunocompromised]] people, such as those with [[HIV]].
* [[Food allergy|Food allergies]] have also been known to cause [[esophagitis]]
* Chemical injury by [[alkaline]] or [[acid]] solutions may also cause [[esophagitis]], and is usually seen in children or in adults who attempt [[suicide]].
* Physical injury resulting from [[radiation therapy]] or by [[nasogastric tube]]s may also be responsible.
===Pathological Findings===
[http://www.peir.net Images courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology]
====Gross Images====
<gallery>
Image:Candida esophagitis 1.jpg|Esophagus: Candida: Gross natural color close up of distal esophagus mucosa, an excellent example of candida esophagitis 
Image:Candida esophagitis 2.jpg|Esophagitis Candida: Gross natural color close-up, an excellent example
</gallery>
<gallery>
Image:Candida esophagitis 3.jpg|Esophagitis Candida: Gross natural color excellent close-up photo case of acute myelomonocytic leukemia
Image:Necrotizing esophagitis 1.jpg|Necrotizing esophagitis and gastritis, sulfuric acid ingested as suicide attempt
</gallery>
====Microscopic Images====
<gallery>
Image:Herpes esophagitis micro 100.jpg|Herpes esophagitis 100 x
Image:Herpes esophagitis micro 400.jpg|Herpes esophagitis 400 x
Image:Herpes esophagitis micro 600.jpg|Herpes esophagitis 600 x
</gallery>
<gallery>
Image:Reflux esophagitis micro 1.jpg|Reflux esophagitis 100 x
Image:Reflux esophagitis micro 2.jpg|Reflux esophagitis 400 x
Image:Necrotizing esophagitis micro 1.jpg|Necrotizing esophagitis and gastritis, sulfuric acid ingested as suicide attempt
</gallery>


====Histopathological Findings: Herpes Esophagitis====
====Histopathological Findings: Herpes Esophagitis====
Line 125: Line 98:
==References==
==References==
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{{reflist|2}}
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[[Category:Primary care]]
[[Category:Gastroenterology]]
[[Category:Gastroenterology]]
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{{WS}}

Latest revision as of 21:41, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Ajay Gade MD[2]] ; Aditya Ganti M.B.B.S. [3]

Overview

The esophagus is a part of the gastrointestinal tract which is responsible of moving the food from the mouth to the rectum. Esophagitis is defined as inflammation of mucosal layer of esophagus. Based on the etiology of inflammation esophagitis can be classified into reflux esophagitis and eosinophilic esophagitis. Any condition that lead to the reflux of the gastric acidic contents into the esophagus results in reflux esophagitis. Eosinophilic esophagitis is an immunoallergic disorder resulting from the interaction between genetics and environmental triggers such as repeated exposure to food and aeroallergens. TH2 inflammatory cell response play a major role in the production of eosinophils. Activated TH2 response leads to the recruitment and activation of eosinophils and mast cells. Characteristic gross pathology findings of esophagitis include fixed esophageal ring, white exudates, longitudinal furrows/ fibrosis, mucosal pallor, Diffuse esophageal narrowing. Characteristic microscopic findings of esophagitis include edema and basal hyperplasia (non-specific inflammatory changes), lymphocytic infiltration, neutrophilic infiltration, eosinophilic infiltration, goblet cell intestinal metaplasia or Barrett's esophagus and elongation of the papillae.

Pathophysiology

Normal physiology of the food motility through the esophagus

Source by:BruceBlaus - Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=44923646

Pathogenesis

Esophagitis is defined as inflammation of mucosal layer of esophagus. Based on the etiology of inflammation esophagitis can be discussed under two categories

  • Reflux esophagitis
  • Eosinophilic esophagitis

Reflux Esophagitis

Pathogenesis of reflux esophagitis depends on various mechanisms that lead to the reflux of the gastric acidic contents into the esophagus. Several mechanisms impair the anti-reflux barrier and cause esophageal dysmotility. These mechanisms include the following:[2][3]

Eosinophilic Esophagitis

Eosinophilic esophagitis is an immunoallergic disorder resulting from the interaction between genetics and environmental triggers such as repeated exposure to food and aeroallergens. The pathophysiology of the EoE is as follows:[7][8][9][10][11][12][13][14][15][16]

Production of eosinophils
  • TH2 inflammatory cell response play a major role in the production of eosinophils.
  • Activated TH2 response leads to the recruitment and activation of eosinophils and mast cells.
  • T cells (Th2) cell response also stimulates production of IL-5 and IL-13.
  • IL-13 stimulates the epithelial cells of the esophagus to induce a gene called eotaxin-3, which in turn recruits eosinophils from the peripheral blood into the tissue.
  • IL-5 prolongs the survival of the eosinophils.
Granule proteins of the eosinophils
ECP Eosinophil Cationic Protein
MBP Major Basic Protein
EPO Eosinophil Peroxidase
EDN Eosinophil Derived Neurotoxin
Role of eosinophils in inflammation

Eosinophils cause inflammation in the EoE patients by the following mechanisms

Gross Pathology

Histopathology

On histopathological analysis, based on the type of esophagitis microscopic findings include:[22]

  • Eosinophilic esophagitis
    • > 20 eosinophils/0.24 mm2.
    • Papillae are elongated
    • Papillae reach into the top 1/3 of the epithelial layer
    • Basal cell hyperplasia; > 3 cells thick or >15% of epithelial thickness
H&E stain of esophagus biopsy showing eosinophilic esophagitis, manifested by an infiltration of eosinophils in the lamina propria


Histopathological Findings: Herpes Esophagitis

{{#ev:youtube|bJME-CJvHfs}}

References

  1. ↑ Stein HJ, DeMeester TR (1992). "Outpatient physiologic testing and surgical management of foregut motility disorders". Curr Probl Surg. 29 (7): 413–555. PMID 1606845.
  2. ↑ Storr M, Meining A, Allescher HD (2000). "Pathophysiology and pharmacological treatment of gastroesophageal reflux disease". Dig Dis. 18 (2): 93–102. doi:10.1159/000016970. PMID 11060472.
  3. ↑ De Giorgi F, Palmiero M, Esposito I, Mosca F, Cuomo R (2006). "Pathophysiology of gastro-oesophageal reflux disease". Acta Otorhinolaryngol Ital. 26 (5): 241–6. PMC 2639970. PMID 17345925.
  4. ↑ Fisher BL, Pennathur A, Mutnick JL, Little AG (1999). "Obesity correlates with gastroesophageal reflux". Dig Dis Sci. 44 (11): 2290–4. PMID 10573376.
  5. ↑ Kahrilas PJ, Shi G, Manka M, Joehl RJ (2000). "Increased frequency of transient lower esophageal sphincter relaxation induced by gastric distention in reflux patients with hiatal hernia". Gastroenterology. 118 (4): 688–95. PMID 10734020.
  6. ↑ Richter J (1999). "Do we know the cause of reflux disease?". Eur J Gastroenterol Hepatol. 11 Suppl 1: S3–9. PMID 10443906.
  7. ↑ Malhotra N, Levine J (2014). "Eosinophilic esophagitis: an autoimmune esophageal disorder". Curr Probl Pediatr Adolesc Health Care. 44 (11): 335–40. doi:10.1016/j.cppeds.2014.10.004. PMID 25499460.
  8. ↑ Martin LJ, Franciosi JP, Collins MH, Abonia JP, Lee JJ, Hommel KA, Varni JW, Grotjan JT, Eby M, He H, Marsolo K, Putnam PE, Garza JM, Kaul A, Wen T, Rothenberg ME (2015). "Pediatric Eosinophilic Esophagitis Symptom Scores (PEESS v2.0) identify histologic and molecular correlates of the key clinical features of disease". J. Allergy Clin. Immunol. 135 (6): 1519–28.e8. doi:10.1016/j.jaci.2015.03.004. PMC 4460579. PMID 26051952.
  9. ↑ Lucendo AJ, Arias A, Tenias JM (2014). "Relation between eosinophilic esophagitis and oral immunotherapy for food allergy: a systematic review with meta-analysis". Ann. Allergy Asthma Immunol. 113 (6): 624–9. doi:10.1016/j.anai.2014.08.004. PMID 25216976.
  10. ↑ López-Colombo A (2012). "[Eosinophilic esophagitis]". Rev Gastroenterol Mex (in Spanish; Castilian). 77 Suppl 1: 1–3. doi:10.1016/j.rgmx.2012.07.002. PMID 22939463.
  11. ↑ Chehade M, Lucendo AJ, Achem SR, Souza RF (2013). "Causes, evaluation, and consequences of eosinophilic esophagitis". Ann. N. Y. Acad. Sci. 1300: 110–8. doi:10.1111/nyas.12243. PMID 24117638.
  12. ↑ Straumann A (2013). "Eosinophilic esophagitis: a bulk of mysteries". Dig Dis. 31 (1): 6–9. doi:10.1159/000347095. PMID 23797116.
  13. ↑ Straumann A (2012). "Eosinophilic esophagitis: rapidly emerging disorder". Swiss Med Wkly. 142: w13513. doi:10.4414/smw.2012.13513. PMID 22307811.
  14. ↑ Schoepfer AM, Simon D, Straumann A (2011). "Eosinophilic oesophagitis: latest intelligence". Clin. Exp. Allergy. 41 (5): 630–9. doi:10.1111/j.1365-2222.2011.03739.x. PMID 21429051.
  15. ↑ Godat S, Moradpour D, Schoepfer A (2011). "[Eosinophilic esophagitis: update 2011]". Rev Med Suisse (in French). 7 (307): 1678–80, 1682. PMID 21987875.
  16. ↑ Potter JW, Saeian K, Staff D, Massey BT, Komorowski RA, Shaker R, Hogan WJ (2004). "Eosinophilic esophagitis in adults: an emerging problem with unique esophageal features". Gastrointest. Endosc. 59 (3): 355–61. PMID 14997131.
  17. ↑ "Vertical lines in distal esophageal mucosa (VLEM): a true endoscopic manifestation of esophagitis in children? - PubMed - NCBI".
  18. ↑ "Fragility of the esophageal mucosa: a pathognomonic endoscopic sign of primary eosinophilic esophagitis? - PubMed - NCBI".
  19. ↑ "Eosinophilic esophagitis: red on microscopy, white on endoscopy. - PubMed - NCBI".
  20. ↑ "The prevalence and diagnostic utility of endoscopic features of eosinophilic esophagitis: a meta-analysis. - PubMed - NCBI".
  21. ↑ Images courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology

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