Carcinoma in situ

(Redirected from Pre-cancer)
Jump to navigation Jump to search
Carcinoma in situ

WikiDoc Resources for Carcinoma in situ

Articles

Most recent articles on Carcinoma in situ

Most cited articles on Carcinoma in situ

Review articles on Carcinoma in situ

Articles on Carcinoma in situ in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Carcinoma in situ

Images of Carcinoma in situ

Photos of Carcinoma in situ

Podcasts & MP3s on Carcinoma in situ

Videos on Carcinoma in situ

Evidence Based Medicine

Cochrane Collaboration on Carcinoma in situ

Bandolier on Carcinoma in situ

TRIP on Carcinoma in situ

Clinical Trials

Ongoing Trials on Carcinoma in situ at Clinical Trials.gov

Trial results on Carcinoma in situ

Clinical Trials on Carcinoma in situ at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Carcinoma in situ

NICE Guidance on Carcinoma in situ

NHS PRODIGY Guidance

FDA on Carcinoma in situ

CDC on Carcinoma in situ

Books

Books on Carcinoma in situ

News

Carcinoma in situ in the news

Be alerted to news on Carcinoma in situ

News trends on Carcinoma in situ

Commentary

Blogs on Carcinoma in situ

Definitions

Definitions of Carcinoma in situ

Patient Resources / Community

Patient resources on Carcinoma in situ

Discussion groups on Carcinoma in situ

Patient Handouts on Carcinoma in situ

Directions to Hospitals Treating Carcinoma in situ

Risk calculators and risk factors for Carcinoma in situ

Healthcare Provider Resources

Symptoms of Carcinoma in situ

Causes & Risk Factors for Carcinoma in situ

Diagnostic studies for Carcinoma in situ

Treatment of Carcinoma in situ

Continuing Medical Education (CME)

CME Programs on Carcinoma in situ

International

Carcinoma in situ en Espanol

Carcinoma in situ en Francais

Business

Carcinoma in situ in the Marketplace

Patents on Carcinoma in situ

Experimental / Informatics

List of terms related to Carcinoma in situ

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Carcinoma in situ (CIS) is an early form of carcinoma defined by the absence of invasion of surrounding tissues. In other words, the neoplastic cells proliferate in their normal habitat, hence the name 'in situ' (Latin for 'in its place'). For example, carcinoma in situ of the skin, also called Bowen's disease is the accumulation of neoplastic epidermal cells within the epidermis only.

For this reason, CIS will usually not form a tumor. Rather, the lesion is flat (in the skin, cervix, etc) or follows the existing architecture of the organ (in the breast, lung, etc). Some CIS, however, form tumors, for example colon polyps or papillary cancer of the bladder.

Many forms of cancer originate from a 'carcinoma in situ' (CIS) lesion. Therefore, CIS is considered a precursor that may, if left untreated long enough, transform into a more malignant form of neoplasm, invasive carcinoma or, in common language, "cancer".

Many doctors will not refer to 'carcinoma in situ' as "cancer" when explaining a laboratory report to a patient. However, because most forms of CIS have a real potential to turn into invasive carcinoma, CIS is usually treated much the same way as a malignant tumor.

In the TNM classification, carinoma in situ is indicated as TisN0M0 (Stage 0).

Dysplasia vs carcinoma in situ vs invasive carcinoma

These terms are related since they represent the three steps of the progression toward cancer:

  • Dysplasia (from the Greek δυσπλασία "malformation", δυσ- "mal-" + πλάθω "to create, to form"), is the earliest form of pre-cancerous lesion recognizable in a biopsy by a pathologist. Dysplasia can be low grade or high grade (see CIS below). The risk of low-grade dysplasia transforming into high-grade dysplasia and, eventually, cancer is low. Treatment is usually easy.
  • Carcinoma in situ is synonymous with high-grade dysplasia in most organs. The risk of transforming into cancer is high. Treatment is still usually easy.
  • Invasive carcinoma, commonly called cancer, is the final step in this sequence. It is a disease that, when left untreated, will invade the host (hence its name) and will probably kill them. It can often, but not always, be treated successfully.

Examples of carcinomata in situ

Related chapters


Template:Tumors de:Carcinoma in situ it:Tumore in situ nl:Carcinoma in situ


Template:WikiDoc Sources