Diffuse large B cell lymphoma classification: Difference between revisions
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==Overview== | ==Overview== | ||
==Classification== | ==Classification== | ||
Diffuse large B-cell lymphoma encompasses a biologically and clinically diverse set of diseases,<ref name="Alizadeh2000">{{cite journal |doi=10.1038/35000501 |pmid=10676951 |title=Distinct types of diffuse large B-cell lymphoma identified by gene expression | Diffuse large B-cell lymphoma encompasses a biologically and clinically diverse set of diseases,<ref name="Alizadeh2000">{{cite journal |doi=10.1038/35000501 |pmid=10676951 |title=Distinct types of diffuse large B-cell lymphoma identified by gene expression | ||
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Classification of large cells based on Immunophenotypic/Genotypic<ref>{{cite web | title = Non-Hodgkin's Lymphomas (NCCN.org) | url = http://www.nccn.org/professionals/physician_gls/PDF/nhl.pdf }}</ref> | Classification of large cells based on Immunophenotypic/Genotypic<ref>{{cite web | title = Non-Hodgkin's Lymphomas (NCCN.org) | url = http://www.nccn.org/professionals/physician_gls/PDF/nhl.pdf }}</ref> | ||
*Diffuse large B-cell lymphoma (DLBCL),NOS | |||
:*T-cell/histocyte-rich large B-cell lymphoma (THRLBCL) | :*T-cell/histocyte-rich large B-cell lymphoma (THRLBCL) | ||
:*Primary DLBCL of the CNS | :*Primary DLBCL of the CNS | ||
| Line 42: | Line 35: | ||
*DLBCL associated with chronic inflammation | *DLBCL associated with chronic inflammation | ||
*Lymphoid granulomatosis | *Lymphoid granulomatosis | ||
*Primary mediastinal(thymic)large B-cell Lymphoma (PMBL) | *Primary mediastinal (thymic) large B-cell Lymphoma (PMBL) | ||
*Intravascular large B-cell lymphoma | *Intravascular large B-cell lymphoma | ||
*ALK-positive large B-cell lymphoma | *ALK-positive large B-cell lymphoma | ||
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{{reflist|2}} | {{reflist|2}} | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Types of cancer]] | [[Category:Types of cancer]] | ||
Revision as of 06:24, 21 August 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Classification
Diffuse large B-cell lymphoma encompasses a biologically and clinically diverse set of diseases,[1] many of which cannot be separated from one another by well-defined and widely accepted criteria.
The World Health Organization (WHO) classification system defines more than a dozen subtypes, each of which can be differentiated based on the
- Location of the tumor
- Presence of other cells within the tumor (such as T cells)
- Other illnesses related to Diffuse large B-cell lymphoma.
- One of these well-defined groupings of particular note is Primary mediastinal B-cell lymphoma, which arises within the thymus or mediastinal lymph nodes.
B-cell lymphoma, unclassifiable
- Tumor may share many features intermediate between Diffuse large B-cell lymphoma and Burkitt lymphoma.
- Tumor may share many features intermediate between Diffuse large B-cell lymphoma and Hodgkin’s lymphoma.
Diffuse large B-cell lymphoma, not otherwise specified
- When a case of Diffuse large B-cell lymphoma does not conform to any of the well-defined subtypes, and is also not considered unclassifiable.
- The majority of Diffuse large B-cell lymphoma cases fall into this category.
- Much research has been devoted to separating this still-heterogeneous group; such distinctions are usually made along lines of
- cellular morphology
- gene expression
- immunohistochemical properties.
Classification of large cells based on Immunophenotypic/Genotypic[2]
- Diffuse large B-cell lymphoma (DLBCL),NOS
- T-cell/histocyte-rich large B-cell lymphoma (THRLBCL)
- Primary DLBCL of the CNS
- Primary cutaneous DLBCL, leg type
- EBV-positive DLBCL of the elderly (EBV + DLBCL)
- DLBCL associated with chronic inflammation
- Lymphoid granulomatosis
- Primary mediastinal (thymic) large B-cell Lymphoma (PMBL)
- Intravascular large B-cell lymphoma
- ALK-positive large B-cell lymphoma
- Plasmablastic lymphoma
- Large B-cell lymphoma arising in HHV8-assciated multicentric Castleman disease (LBCL in HHV8 + MCD)
- Primary effusion lymphoma
- B-cell lymphoma unclassifiable, intermediate between DLBCL(U-DLBCL) and classical Hodgkins lymphoma(CHL)
- Mantle cell Lymphoma(MCL),pleomorphic variant
References
- ↑ Alizadeh, Ash A.; Eisen, Michael B.; Davis, R. Eric; Ma, Chi; Lossos, Izidore S.; Rosenwald, Andreas; Boldrick, Jennifer C.; Sabet, Hajeer; Tran, Truc; Yu, Xin; Powell, John I.; Yang, Liming; Marti, Gerald E.; Moore, Troy; Hudson, James; Lu, Lisheng; Lewis, David B.; Tibshirani, Robert; Sherlock, Gavin; Chan, Wing C.; Greiner, Timothy C.; Weisenburger, Dennis D.; Armitage, James O.; Warnke, Roger; Levy, Ronald; Wilson, Wyndham; Grever, Michael R.; Byrd, John C.; Botstein, David; et al. (2000). "Distinct types of diffuse large B-cell lymphoma identified by gene expression
profiling". Nature. 403 (6769): 503–11. Bibcode:2000Natur.403..503A. doi:10.1038/35000501. PMID 10676951. line feed character in
|title=at position 78 (help) - ↑ "Non-Hodgkin's Lymphomas (NCCN.org)" (PDF).