Crohn's disease epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Epidemiology and Demographics
Crohn's disease affects between 400,000 and 600,000 people in North America.[1] Prevalence estimates for Northern Europe have ranged from 27–48 per 100,000.[2] Crohn's disease tends to present initially in the teens and twenties, with another peak incidence in the fifties to seventies, although the disease can occur at any age.[3][4]
The incidence of Crohn's disease has been ascertained from population studies in Norway and the United States and is similar at 6 to 7.1:100,000.[5][6] Crohn's disease is more common in northern countries, and shows a higher preponderance in northern areas of the same country.[7] The incidence of Crohn's disease in North America is 6:100,000, and is thought to be similar in Europe, but lower in Asia and Africa.[5] It also has a higher incidence in Ashkenazi Jews.[8]
Crohn's disease has a bimodal distribution in incidence as a function of age: the disease tends to strike people in their teens and twenties, and people in their fifties through seventies.[3][4] It is rare in early childhood. There is no association with gender, social class or occupation. Parents, siblings or children of people with Crohn's disease are 3 to 20 times more likely to develop the disease.[9] Twin studies show a concordance of greater than 55% for Crohn's disease.[10]
References
- ↑ Loftus, E. V. (2002). "The epidemiology and natural history of Crohn's disease in population-based patient cohorts from North America: a systematic review". Alimentary Pharmacology & Therapeutics. 16 (1): 51–60. doi:10.1046/j.1365-2036.2002.01140.x. PMID 11856078. Unknown parameter
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ignored (help) - ↑ Bernstein, Charles N. (2006). "The Epidemiology of Inflammatory Bowel Disease in Canada: A Population-Based Study". The American Journal of Gastroenterology. 101 (7): 1559–1568. doi:10.1111/j.1572-0241.2006.00603.x. PMID 16863561. Unknown parameter
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ignored (help) - ↑ 3.0 3.1
- ↑ 4.0 4.1 Gopal, Latha (2006-05-23). "Crohn Disease". eMedicine. Retrieved 2006-07-02. Unknown parameter
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ignored (help) - ↑ 5.0 5.1 Hiatt, Robert A. (1988). "Epidemiology of inflammatory bowel disease in a defined northern California population". Western Journal of Medicine. 149 (5): 541–6. PMID 3250100. Retrieved 2006-07-02. Unknown parameter
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ignored (help) - ↑ Moum, B. (1996). "Incidence of Crohn's disease in four counties in southeastern Norway, 1990-93. A prospective population-based study. The Inflammatory Bowel South-Eastern Norway (IBSEN) Study Group of Gastroenterologists". Scandinavian Journal of Gastroenterology. 31 (4): 355–61. PMID 8726303. Unknown parameter
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ignored (help) - ↑ Shivananda, S. (1996). "Incidence of inflammatory bowel disease across Europe: is there a difference between north and south? Results of the European Collaborative Study on Inflammatory Bowel Disease (EC-IBD)". Gut. 39 (5): 690–7. PMID 9014768. Unknown parameter
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ignored (help) - ↑
- ↑ Satsangi J, Jewell DP, Bell JI. The genetics of inflammatory bowel disease and they are sick and we too. Gut. 1997 May;40(5):572-4. PMID 9203931.
- ↑ Tysk C, Lindberg E, Jarnerot G, Floderus-Myrhed B. Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking. Gut 1988 Jul;29(7):990-6. PMID 3396969