Ceftizoxime: Difference between revisions

Revision as of 03:36, 31 December 2013

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Ceftizoxime is a third-generation cephalosporin available for parenteral administration.

Unlike other 3rd generation cephalosporins, in ceftizoxime the whole C-3 side chain has been removed to prevent deactivation by hydrolytic enzymes. It rather resembles cefotaxime in its properties, but is not subjected to metabolism.

US Brand Names

CEFIZOX

FDA Package Insert

Mechanism of Action

References

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-{{refimprove|date=April 2013}}
-{{Drugbox
-| IUPAC_name = (6''R'',7''R'')-7-{[(2''Z'')-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
-| image = ceftizoxime.png
-<!--Clinical data-->
-| tradename = Cefizox
-| Drugs.com = {{drugs.com|CDI|ceftizoxime}}
-| MedlinePlus = a684043
-| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
-| pregnancy_US = <!-- A / B            / C / D / X -->
-| pregnancy_category =
-| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
-| legal_CA = <!--             / Schedule I, II, III, IV, V, VI, VII, VIII -->
-| legal_UK = <!-- GSL         / P       / POM / CD / Class A, B, C -->
-| legal_US = <!-- OTC                   / Rx-only  / Schedule I, II, III, IV, V -->
-| legal_status =
-| routes_of_administration =
-<!--Pharmacokinetic data-->
-| bioavailability =
-| protein_bound =
-| metabolism =
-| elimination_half-life =
-| excretion =
-<!--Identifiers-->
-| CAS_number = 68401-81-0
-| CAS_supplemental = {{CAS|68401-82-1}}
-| ATC_prefix = J01
-| ATC_suffix = DD07
-| PubChem = 6533629
-| DrugBank =
-| ChemSpiderID = 5018818
-| UNII_Ref = {{fdacite|correct|FDA}}
-| UNII = C43C467DPE
-| KEGG = D07658
-| ChEMBL = 528
-<!--Chemical data-->
-| C=13 | H=13 | N=5 | O=5 | S=2
-| molecular_weight = 383.405 g/mol
-}}
 __NOTOC__
 {{CMG}}