CYP2B6

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cytochrome P450, family 2, subfamily B, polypeptide 6
Identifiers
SymbolCYP2B6
Entrez1555
HUGO2615
OMIM123930
RefSeqNM_000767
UniProtP20813
Other data
LocusChr. 19 q13.2

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Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

CYP2B6 is a member of the Cytochrome P450 group of enzymes. Along with CYP2A6, it is involved with metabolizing nicotine, along with many other substances.

CYP2B6 Ligands

Substrates Inhibitors Inducers
Often mentioned [1]:
Bupropion (antidepressant)
Cyclophosphamide (Alkylating antineoplastic agent)
Efavirenz (NNRTI)
Ifosfamide (Alkylating antineoplastic agent)

Other:
Alfentanil (opioid analgesic)
Nevirapine (NNRTI)
Propofol (anesthetic)
tamoxifen (SERM)
Valproic acid (anticonvulsant , mood-stabilizing)
Artemisinin (against malaria)
Pethidine (analgesic)
Nicotine (stimulant)
Sertraline (SSRI)
thiotepa (Alkylating antineoplastic agent)

Strong [2]:
Orphenadrine (analgesic)


unspecified:
Paroxetine (SSRI)
fluoxetine (SSRI)
Estradiol (sex hormone)
Phencyclidine (dissociative)
ritonavir (antiretroviral)
sertraline (SSRI)
thiotepa (Alkylating antineoplastic agent)
ticlopidine (antiplatelet)

Often mentioned [1]:
carbamazepine (anticonvulsant, mood stabilizer)
rifampicin (bactericidal)

Other:
artemisinin (against malaria)
clotrimazole (antifungal)
ifosfamide (Alkylating antineoplastic agent)
glucocorticoids (antiinflammatory)
phenobarbital (anticonvulsant )
phenytoin (antiepileptic)
ritonavir (antiretroviral)

External links

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Template:WH Template:WikiDoc Sources

  1. 1.0 1.1 Mentioned both in the reference named FASS and were previously mentioned in Wikipedia. Further contributions may follow other systems
  2. Swedish environmental classification of pharmaceuticals Facts for prescribers (Fakta för förskrivare)