Hairy cell leukemia laboratory tests

	Hairy cell leukemia Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Hairy cell leukemia from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
Staging
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
Chest X Ray
CT
MRI
Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Hairy cell leukemia laboratory tests On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Hairy cell leukemia laboratory tests All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Hairy cell leukemia laboratory tests
CDC on Hairy cell leukemia laboratory tests
Hairy cell leukemia laboratory tests in the news
Blogs on Hairy cell leukemia laboratory tests
Directions to Hospitals Treating Hairy cell leukemia
Risk calculators and risk factors for Hairy cell leukemia laboratory tests

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

Laboratory findings consistent with the diagnosis of hairy cell leukemia include abnormal complete blood count, immunohistochemistry, and flow cytometry. The presence of hairy cells with thread-like cytoplasmic extensions on blood smear is a key diagnostic feature among patients with hairy cell leukemia.

Laboratory Findings

Complete Blood Count

Decreased hemoglobin concentration^[1]
Decreased platelets count
Decreased WBC count

Blood Smear

Hairy cells with thread-like cytoplasmic extensions^[1]
Positive TRAP stain

Immunohistochemistry

On immunohistochemistry, characteristic findings of hairy cell leukemia include:^[1]^[2]

Annexin A1 +ve
CD20 +ve
CD25 +ve
CD103 +ve

Flow Cytometry

On flow cytometry, characteristic findings of hairy cell leukemia include:^[1]^[2]

CD19 +ve
CD11c +ve
FMC7 +ve

References

↑ ^1.0 ^1.1 ^1.2 ^1.3 Somasundaram V, Purohit A, Aggarwal M, Manivannan P, Mishra P, Seth T, Tyagi S, Mahapatra M, Pati HP, Saxena R (2014). "Hairy cell leukemia: A decade long experience of North Indian Hematology Center". Indian J Med Paediatr Oncol. 35 (4): 271–5. doi:10.4103/0971-5851.144988. PMC 4264273. PMID 25538404.
↑ ^2.0 ^2.1 Small cell lymphoma. Libre Pathology (2015) http://librepathology.org/wiki/index.php/Small_cell_lymphomas#Hairy_cell_leukemia Accessed on October, 8 2015

Template:WikiDoc Sources

[pub-1] 1.0 ^1.1 ^1.2 ^1.3 Somasundaram V, Purohit A, Aggarwal M, Manivannan P, Mishra P, Seth T, Tyagi S, Mahapatra M, Pati HP, Saxena R (2014). "Hairy cell leukemia: A decade long experience of North Indian Hematology Center". Indian J Med Paediatr Oncol. 35 (4): 271–5. doi:10.4103/0971-5851.144988. PMC 4264273. PMID 25538404.

[patho-2] 2.0 ^2.1 Small cell lymphoma. Libre Pathology (2015) http://librepathology.org/wiki/index.php/Small_cell_lymphomas#Hairy_cell_leukemia Accessed on October, 8 2015

[1]

[2]