Sandbox ID Skin and Soft Tissues

Animal bite
Preferred regimen (1): Amoxicillin-clavulanate 875/125 mg PO bid (Some gram-negative rods are resistant; misses MRSA)
Preferred regimen (2): Ampicillin-sulbactam 1.5–3.0 g IV every 6–8 h (Some gram-negative rods are resistant; misses MRSA)
Preferred regimen (3): Piperacillin-tazobactam 3.37 g IV every 6–8 h (Misses MRSA)
Preferred regimen (4): Doxycycline 100 mg PO bid OR 100 mg IV every 12 h (Excellent activity against Pasteurella multocida; some streptococci are resistant)
Preferred regimen (5): Penicillin AND dicloxacillin 500 mg oral

Preferred regimen (6): SMX-TMP 160–800 mg PO bid OR IV 5–10 mg/kg/day of TMP component (Good activity against aerobes; poor activity against anaerobes)

Preferred regimen (7): Metronidazole250–500 mg PO tid OR 500 mg IV every 8 h (Good activity against anaerobes; no activity against aerobes)
Preferred regimen (8): Clindamycin300 mg PO tid OR 600 mg IV every 6–8 h (Good activity against staphylococci, streptococci, and anaerobes; misses P. multocida)

Preferred regimen (15): Moxifloxacin 400 mg PO daily OR 400 mg IV daily (Monotherapy; good for anaerobes also)

Human bite
Preferred regimen (15): Amoxicillin-clavulanate 875/125 mg PO bid (Some gram-negative rods are resistant; misses MRSA)
Preferred regimen (15): Ampicillin-sulbactam 1.5–3.0 g IV every 6 h (Some gram-negative rods are resistant; misses MRSA)
Preferred regimen (15): Doxycycline PO 100 mg bid (Good activity against Eikenella species, staphylococci, and anaerobes; some streptococci are resistant)

Preferred regimen (1): (Penicillin Voral 500 mg 4 times daily (qid) for 7–10 days
Preferred regimen (2): (Ciprofloxacin 500 mg by mouth (po) bid OR levofloxacin 500 mg intravenously (IV)/po every 24 hours × 60 days is recommended for bioterrorism cases because of presumed aerosol exposure

Patients >45 kg: 500 mg on day 1 followed by 250 mg for 4 additional days
Patients <45 kg: 10 mg/kg on day 1 and 5 mg/kg for 4 more days
Preferred regimen (2): (erythromycin 500 mg by mouth (po) qid OR doxycycline 100 mg bid orally for 2 weeks to 2 months

Preferred regimen: (Penicillin (500 mg qid) OR amoxicillin (500 mg 3 times daily [tid]) for 7–10 days

Preferred regimen: (Ceftazidime, gentamicin, imipenem, doxycycline, or ciprofloxacin is recommended based on in vitro susceptibility

Preferred regimen: (streptomycin (15 mg/kg intramuscularly [IM] every 12 hours) OR doxycycline (100 mg bid po) OR gentamicin could be substituted for streptomycin

Preferred regimen (1): (streptomycin (15 mg/kg every 12 hours IM) OR gentamicin (1.5 mg/kg every 8 hours IV)
Preferred regimen (2): (tetracycline (500 mg qid) OR doxycycline (100 mg bid po) is recommended for treatment of mild cases of tularemia

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