Hairy cell leukemia causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]
Overview
Hairy cell leukemia may be caused by mutations in BRAF gene and exposure to radiation, pesticides
Causes
Causes of Hairy cell leukemia may include:[1][2][3]
- Genetic mutations most common
- radiation exposure
- Pesticide exposure
- HLA haplotype which is sharing among family members
Genetic Causes
- Hairy cell leukemia is caused by a mutation in the BRAF V600E gene mutation.
References
- ↑ Stewart DJ, Keating MJ (October 1980). "Radiation exposure as a possible etiologic factor in hairy cell leukemia (leukemic reticuloendotheliosis)". Cancer. 46 (7): 1577–80. PMID 7417955.
- ↑ Monnereau A, Slager SL, Hughes AM, Smith A, Glimelius B, Habermann TM, Berndt SI, Staines A, Norman AD, Cerhan JR, Sampson JN, Morton LM, Clavel J (August 2014). "Medical history, lifestyle, and occupational risk factors for hairy cell leukemia: the InterLymph Non-Hodgkin Lymphoma Subtypes Project". J. Natl. Cancer Inst. Monographs. 2014 (48): 115–24. doi:10.1093/jncimonographs/lgu004. PMC 4155459. PMID 25174032.
- ↑ Orsi L, Delabre L, Monnereau A, Delval P, Berthou C, Fenaux P, Marit G, Soubeyran P, Huguet F, Milpied N, Leporrier M, Hemon D, Troussard X, Clavel J (May 2009). "Occupational exposure to pesticides and lymphoid neoplasms among men: results of a French case-control study". Occup Environ Med. 66 (5): 291–8. doi:10.1136/oem.2008.040972. PMC 2728754. PMID 19017688.