Hairy cell leukemia laboratory tests

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

Laboratory findings consistent with the diagnosis of hairy cell leukemia include abnormal complete blood count, immunohistochemistry, and flow cytometry. The presence of hairy cells with thread-like cytoplasmic extensions on blood smear is a key diagnostic feature among patients with hairy cell leukemia.

Laboratory Findings

Complete Blood Count

Decreased hemoglobin concentration^[1]
Decreased platelets count
Decreased WBC count

Blood Smear

Hairy cells with thread-like cytoplasmic extensions^[1]
Positive TRAP stain

Immunohistochemistry

On immunohistochemistry, characteristic findings of hairy cell leukemia include:^[1]

Annexin A1 +ve
CD20 +ve
CD25 +ve
CD103 +ve

Flow Cytometry

On flow cytometry, characteristic findings of hairy cell leukemia include:^[1]

CD19 +ve
CD11c +ve
FMC7 +ve

References

↑ ^1.0 ^1.1 ^1.2 ^1.3 Somasundaram V, Purohit A, Aggarwal M, Manivannan P, Mishra P, Seth T, Tyagi S, Mahapatra M, Pati HP, Saxena R (2014). "Hairy cell leukemia: A decade long experience of North Indian Hematology Center". Indian J Med Paediatr Oncol. 35 (4): 271–5. doi:10.4103/0971-5851.144988. PMC 4264273. PMID 25538404.

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[pub-1] 1.0 ^1.1 ^1.2 ^1.3 Somasundaram V, Purohit A, Aggarwal M, Manivannan P, Mishra P, Seth T, Tyagi S, Mahapatra M, Pati HP, Saxena R (2014). "Hairy cell leukemia: A decade long experience of North Indian Hematology Center". Indian J Med Paediatr Oncol. 35 (4): 271–5. doi:10.4103/0971-5851.144988. PMC 4264273. PMID 25538404.

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