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{{Infobox_Disease | | {{Infobox_Disease | | ||
Name = {{PAGENAME}} | | Name = {{PAGENAME}} | | ||
Image = | | Image = | | ||
Caption = | | Caption = | | ||
DiseasesDB = 5363 | | DiseasesDB = 5363 | | ||
ICD10 = {{ICD10|M|31|0|m|30}} ([[ILDS]] M31.010) | | ICD10 = {{ICD10|M|31|0|m|30}} ([[ILDS]] M31.010) | | ||
ICD9 = {{ICD9|446.21}} | | ICD9 = {{ICD9|446.21}} | | ||
ICDO = | | ICDO = | | ||
OMIM = 233450 | | OMIM = 233450 | | ||
MedlinePlus = | | MedlinePlus = | | ||
MeshID = D019867 | | MeshID = D019867 | | ||
}} | }} | ||
{{SI}} | {{SI}} | ||
'''For patient information click [[{{PAGENAME}} (patient information)|here]]''' | '''For patient information click [[{{PAGENAME}} (patient information)|here]]''' | ||
{{CMG}}; '''Associate Editor-In-Chief:''' {{CZ}} | {{CMG}}; '''Associate Editor-In-Chief:''' {{CZ}} | ||
== Overview == | == Overview == | ||
'''Goodpasture’s syndrome''' (also known as '''Goodpasture’s disease''' and '''anti-glomerular basement membrane disease''') is a rare condition characterised by rapid destruction of the [[kidney]]s and hemorrhaging of the [[lung]]s. | '''Goodpasture’s syndrome''' (also known as '''Goodpasture’s disease''' and '''anti-glomerular basement membrane disease''') is a rare condition characterised by rapid destruction of the [[kidney]]s and hemorrhaging of the [[lung]]s. | ||
Although many diseases can present with these symptoms, the name Goodpasture’s syndrome is usually reserved for the [[autoimmune disease]] produced when the patient’s [[immune system]] attacks cells presenting the Goodpasture [[antigen]], which are found in the kidney and lung, causing damage to these organs. | Although many diseases can present with these symptoms, the name Goodpasture’s syndrome is usually reserved for the [[autoimmune disease]] produced when the patient’s [[immune system]] attacks cells presenting the Goodpasture [[antigen]], which are found in the kidney and lung, causing damage to these organs. | ||
== Signs and symptoms == | == Signs and symptoms == | ||
Most patients present with both lung and kidney disease, however, some patients present with one of these diseases alone. The first lung symptoms usually develop days to months before kidney damage is evident. There is an increased incidence of syndactly. | Most patients present with both lung and kidney disease, however, some patients present with one of these diseases alone. The first lung symptoms usually develop days to months before kidney damage is evident. There is an increased incidence of syndactly. | ||
=== Lung disease === | === Lung disease === | ||
Lung damage may cause nothing more serious than a dry [[cough]] and minor [[breathlessness]] and such mild symptoms may last for many years before more severe ones develop. At its most serious, however, lung damage may cause severe impairment of oxygenation so that intensive care is required. Deterioration between the two extremes may occur very rapidly, often at the same time as rapid deterioration in the kidney. The patient often does not seek medical attention until he or she begins coughing up blood ([[hemoptysis]]). The patient may be [[anemia|anemic]] due to loss of blood through lung haemorrhaging over a long period. In Goodpasture’s syndrome, unlike many other conditions that cause similar symptoms, lung hemorrhaging most often occurs in [[tobacco smoking|smokers]] and those with damage from lung [[infectious disease|infection]] or exposure to fumes. | Lung damage may cause nothing more serious than a dry [[cough]] and minor [[breathlessness]] and such mild symptoms may last for many years before more severe ones develop. At its most serious, however, lung damage may cause severe impairment of oxygenation so that intensive care is required. Deterioration between the two extremes may occur very rapidly, often at the same time as rapid deterioration in the kidney. The patient often does not seek medical attention until he or she begins coughing up blood ([[hemoptysis]]). The patient may be [[anemia|anemic]] due to loss of blood through lung haemorrhaging over a long period. In Goodpasture’s syndrome, unlike many other conditions that cause similar symptoms, lung hemorrhaging most often occurs in [[tobacco smoking|smokers]] and those with damage from lung [[infectious disease|infection]] or exposure to fumes. | ||
| Line 99: | Line 72: | ||
=== Kidney disease === | === Kidney disease === | ||
The kidney disease mostly affects the [[glomerulus|glomeruli]] causing a form of [[nephritis]]. It is usually not detected until a rapid advance of the disease occurs so that kidney function can be completely lost in a matter of days, a condition known as rapidly progressive glomerulonephritis, or RPGN. [[Blood]] leaks into the [[urine]] causing [[hematuria|hematuria]], the volume urinated decreases and [[urea]] and other products usually excreted by the kidney are retained and build up in the blood. This is [[acute renal failure]]. Renal failure does not cause symptoms until more than 80% of kidney function has been lost. Symptoms include loss of appetite and sickness at first and then, when the damage is more advanced, breathlessness, high [[blood pressure]] and [[edema]] (swelling caused by fluid retention). The kidney involvement usually presents as [[nephritic syndrome]], i.e. hematuria, a reduced [[glomerular filtration rate]], and high blood pressure. This is in contrast to [[nephrotic syndrome]], a more rare outcome of Goodpasture's, characterized by an abnormally large amount protein in the urine (proteinuria), coupled with severe edema. | The kidney disease mostly affects the [[glomerulus|glomeruli]] causing a form of [[nephritis]]. It is usually not detected until a rapid advance of the disease occurs so that kidney function can be completely lost in a matter of days, a condition known as rapidly progressive glomerulonephritis, or RPGN. [[Blood]] leaks into the [[urine]] causing [[hematuria|hematuria]], the volume urinated decreases and [[urea]] and other products usually excreted by the kidney are retained and build up in the blood. This is [[acute renal failure]]. Renal failure does not cause symptoms until more than 80% of kidney function has been lost. Symptoms include loss of appetite and sickness at first and then, when the damage is more advanced, breathlessness, high [[blood pressure]] and [[edema]] (swelling caused by fluid retention). The kidney involvement usually presents as [[nephritic syndrome]], i.e. hematuria, a reduced [[glomerular filtration rate]], and high blood pressure. This is in contrast to [[nephrotic syndrome]], a more rare outcome of Goodpasture's, characterized by an abnormally large amount protein in the urine (proteinuria), coupled with severe edema. | ||
== Diagnosis == | == Diagnosis == | ||
Because of the vagueness of early symptoms and rapid progression of the disease, diagnosis is often not reached until very late in the course of the disease. Kidney [[biopsy]] is often the fastest way to secure the diagnosis and gain information about the extent of the disease and likely effect of treatment. Tests for anti-GBM [[antibody|antibodies]] may also be useful, combined with tests for antibodies to neutrophil cytoplasmic antigens, which are also directed against the patient’s own proteins. | Because of the vagueness of early symptoms and rapid progression of the disease, diagnosis is often not reached until very late in the course of the disease. Kidney [[biopsy]] is often the fastest way to secure the diagnosis and gain information about the extent of the disease and likely effect of treatment. Tests for anti-GBM [[antibody|antibodies]] may also be useful, combined with tests for antibodies to neutrophil cytoplasmic antigens, which are also directed against the patient’s own proteins. | ||
=== Pathology === | === Pathology === | ||
[[Image:Goodpasture Disease.jpg|thumb|center|Goodpasture Disease<ref>http://picasaweb.google.com/mcmumbi/USMLEIIImages</ref>]] | [[Image:Goodpasture Disease.jpg|thumb|center|Goodpasture Disease<ref>http://picasaweb.google.com/mcmumbi/USMLEIIImages</ref>]] | ||
== Pathophysiology == | == Pathophysiology == | ||
As with many autoimmune conditions, the precise cause of Goodpasture’s Syndrome is not yet known. It is believed to be a type II [[hypersensitivity]] reaction to Goodpasture’s antigens on the cells of the [[glomerulus|glomeruli]] of the kidneys and the [[pulmonary alveolus|pulmonary alveoli]], specifically the basement membrane's (including a-3 chain of type IV collagen), whereby the immune system wrongly recognizes these cells as foreign and attacks and destroys them, as it would an invading [[pathogen]]. | As with many autoimmune conditions, the precise cause of Goodpasture’s Syndrome is not yet known. It is believed to be a type II [[hypersensitivity]] reaction to Goodpasture’s antigens on the cells of the [[glomerulus|glomeruli]] of the kidneys and the [[pulmonary alveolus|pulmonary alveoli]], specifically the basement membrane's (including a-3 chain of type IV collagen), whereby the immune system wrongly recognizes these cells as foreign and attacks and destroys them, as it would an invading [[pathogen]]. | ||
== Treatment == | == Treatment == | ||
Like many autoimmune diseases, Goodpasture’s syndrome responds well to treatment with [[corticosteroid]]s and [[immunosuppressant]]s. These drugs dampen the body's normal immune response. A serious side effect of this is that the patient may become more susceptible to infections. The concentration of anti-GBM antibodies in the blood may be reduced by [[apheresis]] to remove blood plasma and its replacement with an isotonic salt and protein solution. This course of treatment usually lasts between three and six months. | Like many autoimmune diseases, Goodpasture’s syndrome responds well to treatment with [[corticosteroid]]s and [[immunosuppressant]]s. These drugs dampen the body's normal immune response. A serious side effect of this is that the patient may become more susceptible to infections. The concentration of anti-GBM antibodies in the blood may be reduced by [[apheresis]] to remove blood plasma and its replacement with an isotonic salt and protein solution. This course of treatment usually lasts between three and six months. | ||
[[Antibiotic]] treatment of lung infection and stopping smoking may also help to reduce lung haemorrhaging. | [[Antibiotic]] treatment of lung infection and stopping smoking may also help to reduce lung haemorrhaging. | ||
However, none of these can reverse permanent kidney damage and so for patients who have suffered this, renal [[organ transplant|transplant]] once the disease has subsided may be the only option. | However, none of these can reverse permanent kidney damage and so for patients who have suffered this, renal [[organ transplant|transplant]] once the disease has subsided may be the only option. | ||
== Epidemiology == | == Epidemiology == | ||
Goodpasture’s syndrome is rare. In European populations between half and one case presents per million people per year. It is rarer than this in non-European populations. While cases have occurred in patients between the ages of 4 and 80, it is most common between ages 18 and 30 and again between 50 and 65. Males are six times more affected than females. | Goodpasture’s syndrome is rare. In European populations between half and one case presents per million people per year. It is rarer than this in non-European populations. While cases have occurred in patients between the ages of 4 and 80, it is most common between ages 18 and 30 and again between 50 and 65. Males are six times more affected than females. | ||
== Prognosis == | == Prognosis == | ||
In the 1970s, Goodpasture’s syndrome was most often fatal, but due to advances in diagnosis and treatment deaths are less common now. Death from lung hemorrhage may occur before the diagnosis has been made or in the initial stages of treatment before it has been properly controlled. With treatment, however, the patient can usually recover completely from lung damage. Kidneys, though, are less able to repair themselves and patients with kidney damage must often resort of a life on [[dialysis]] or kidney transplantation. Even with the best management there is still a significant mortality from renal failure, particularly if the patient is otherwise in poor health. It must also be remembered that the immunosuppressive treatment many patients are put on increases their risk of infection with a number of serious or fatal diseases. | In the 1970s, Goodpasture’s syndrome was most often fatal, but due to advances in diagnosis and treatment deaths are less common now. Death from lung hemorrhage may occur before the diagnosis has been made or in the initial stages of treatment before it has been properly controlled. With treatment, however, the patient can usually recover completely from lung damage. Kidneys, though, are less able to repair themselves and patients with kidney damage must often resort of a life on [[dialysis]] or kidney transplantation. Even with the best management there is still a significant mortality from renal failure, particularly if the patient is otherwise in poor health. It must also be remembered that the immunosuppressive treatment many patients are put on increases their risk of infection with a number of serious or fatal diseases. | ||
== See also == | == See also == | ||
[[HLA-DR#DR2]] | [[HLA-DR#DR2]] | ||
== References == | == References == | ||
{{Reflist|2}} | {{Reflist|2}} | ||
== External links == | == External links == | ||
[http://www.antibodypatterns.com/gbm.php GBM antibodies: immunofluorescence image] | [http://www.antibodypatterns.com/gbm.php GBM antibodies: immunofluorescence image] | ||
{{Diseases of the musculoskeletal system and connective tissue}} | {{Diseases of the musculoskeletal system and connective tissue}} | ||
[[Category:Autoimmune diseases]] | [[Category:Autoimmune diseases]] | ||
[[Category:Kidney diseases]] | [[Category:Kidney diseases]] | ||
[[Category:Rheumatology]] | [[Category:Rheumatology]] | ||
[[de:Goodpasture-Syndrom]] | [[de:Goodpasture-Syndrom]] | ||
[[es:Síndrome de Goodpasture]] | [[es:Síndrome de Goodpasture]] | ||
[[ja:グッドパスチャー症候群]] | [[ja:グッドパスチャー症候群]] | ||
[[ru:Синдром Гудпасчера]] | [[ru:Синдром Гудпасчера]] | ||
[[fi:Goodpasturen oireyhtymä]] | [[fi:Goodpasturen oireyhtymä]] | ||
[[sv:Goodpastures syndrom]] | [[sv:Goodpastures syndrom]] | ||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
Revision as of 16:36, 24 September 2012
| Sandbox | |
| ICD-10 | M31.0 (ILDS M31.010) |
|---|---|
| ICD-9 | 446.21 |
| OMIM | 233450 |
| DiseasesDB | 5363 |
| MeSH | D019867 |
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For patient information click here
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]
Overview
Goodpasture’s syndrome (also known as Goodpasture’s disease and anti-glomerular basement membrane disease) is a rare condition characterised by rapid destruction of the kidneys and hemorrhaging of the lungs.
Although many diseases can present with these symptoms, the name Goodpasture’s syndrome is usually reserved for the autoimmune disease produced when the patient’s immune system attacks cells presenting the Goodpasture antigen, which are found in the kidney and lung, causing damage to these organs.
Signs and symptoms
Most patients present with both lung and kidney disease, however, some patients present with one of these diseases alone. The first lung symptoms usually develop days to months before kidney damage is evident. There is an increased incidence of syndactly.
Lung disease
Lung damage may cause nothing more serious than a dry cough and minor breathlessness and such mild symptoms may last for many years before more severe ones develop. At its most serious, however, lung damage may cause severe impairment of oxygenation so that intensive care is required. Deterioration between the two extremes may occur very rapidly, often at the same time as rapid deterioration in the kidney. The patient often does not seek medical attention until he or she begins coughing up blood (hemoptysis). The patient may be anemic due to loss of blood through lung haemorrhaging over a long period. In Goodpasture’s syndrome, unlike many other conditions that cause similar symptoms, lung hemorrhaging most often occurs in smokers and those with damage from lung infection or exposure to fumes.
Kidney disease
The kidney disease mostly affects the glomeruli causing a form of nephritis. It is usually not detected until a rapid advance of the disease occurs so that kidney function can be completely lost in a matter of days, a condition known as rapidly progressive glomerulonephritis, or RPGN. Blood leaks into the urine causing hematuria, the volume urinated decreases and urea and other products usually excreted by the kidney are retained and build up in the blood. This is acute renal failure. Renal failure does not cause symptoms until more than 80% of kidney function has been lost. Symptoms include loss of appetite and sickness at first and then, when the damage is more advanced, breathlessness, high blood pressure and edema (swelling caused by fluid retention). The kidney involvement usually presents as nephritic syndrome, i.e. hematuria, a reduced glomerular filtration rate, and high blood pressure. This is in contrast to nephrotic syndrome, a more rare outcome of Goodpasture's, characterized by an abnormally large amount protein in the urine (proteinuria), coupled with severe edema.
Diagnosis
Because of the vagueness of early symptoms and rapid progression of the disease, diagnosis is often not reached until very late in the course of the disease. Kidney biopsy is often the fastest way to secure the diagnosis and gain information about the extent of the disease and likely effect of treatment. Tests for anti-GBM antibodies may also be useful, combined with tests for antibodies to neutrophil cytoplasmic antigens, which are also directed against the patient’s own proteins.
Pathology
Pathophysiology
As with many autoimmune conditions, the precise cause of Goodpasture’s Syndrome is not yet known. It is believed to be a type II hypersensitivity reaction to Goodpasture’s antigens on the cells of the glomeruli of the kidneys and the pulmonary alveoli, specifically the basement membrane's (including a-3 chain of type IV collagen), whereby the immune system wrongly recognizes these cells as foreign and attacks and destroys them, as it would an invading pathogen.
Treatment
Like many autoimmune diseases, Goodpasture’s syndrome responds well to treatment with corticosteroids and immunosuppressants. These drugs dampen the body's normal immune response. A serious side effect of this is that the patient may become more susceptible to infections. The concentration of anti-GBM antibodies in the blood may be reduced by apheresis to remove blood plasma and its replacement with an isotonic salt and protein solution. This course of treatment usually lasts between three and six months.
Antibiotic treatment of lung infection and stopping smoking may also help to reduce lung haemorrhaging.
However, none of these can reverse permanent kidney damage and so for patients who have suffered this, renal transplant once the disease has subsided may be the only option.
Epidemiology
Goodpasture’s syndrome is rare. In European populations between half and one case presents per million people per year. It is rarer than this in non-European populations. While cases have occurred in patients between the ages of 4 and 80, it is most common between ages 18 and 30 and again between 50 and 65. Males are six times more affected than females.
Prognosis
In the 1970s, Goodpasture’s syndrome was most often fatal, but due to advances in diagnosis and treatment deaths are less common now. Death from lung hemorrhage may occur before the diagnosis has been made or in the initial stages of treatment before it has been properly controlled. With treatment, however, the patient can usually recover completely from lung damage. Kidneys, though, are less able to repair themselves and patients with kidney damage must often resort of a life on dialysis or kidney transplantation. Even with the best management there is still a significant mortality from renal failure, particularly if the patient is otherwise in poor health. It must also be remembered that the immunosuppressive treatment many patients are put on increases their risk of infection with a number of serious or fatal diseases.
See also
References
External links
GBM antibodies: immunofluorescence image
Template:Diseases of the musculoskeletal system and connective tissue