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{{Hypertrophic cardiomyopathy}}


'''Editors-In-Chief:''' C. Michael Gibson, M.S., M.D. [mailto:mgibson@perfuse.org], Cafer Zorkun, M.D. [mailto:zorkun@perfuse.org], Caitlin J. Harrigan [mailto:charrigan@perfuse.org], Martin S. Maron, M.D., and Barry J. Maron, M.D.
'''Editors-In-Chief:''' C. Michael Gibson, M.S., M.D. [mailto:mgibson@perfuse.org], Martin S. Maron, M.D., and Barry J. Maron, M.D.


==Overview==
==Sudden Cardiac Death==
==Sudden Cardiac Death==
The incidence of [[sudden cardiac death]] (SCD) in patients with HCM is 2 to 4 percent per year in adults, and a 4 to 6 percent per year in children and adolescents<ref name="pmid11127463">{{cite journal| author=Elliott PM, Poloniecki J, Dickie S, Sharma S, Monserrat L, Varnava A et al.| title=Sudden death in hypertrophic cardiomyopathy: identification of high risk patients. | journal=J Am Coll Cardiol | year= 2000 | volume= 36 | issue= 7 | pages= 2212-8 | pmid=11127463 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11127463  }} </ref>.
The incidence of [[sudden cardiac death]] (SCD) in patients with HCM is 2 to 4 percent per year in adults, and a 4 to 6 percent per year in children and adolescents<ref name="pmid11127463">{{cite journal| author=Elliott PM, Poloniecki J, Dickie S, Sharma S, Monserrat L, Varnava A et al.| title=Sudden death in hypertrophic cardiomyopathy: identification of high risk patients. | journal=J Am Coll Cardiol | year= 2000 | volume= 36 | issue= 7 | pages= 2212-8 | pmid=11127463 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11127463  }} </ref>.
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==References==
==References==
{{reflist|2}}
{{Reflist|2}}


[[Category: Cardiology]]
[[Category: Cardiology]]
[[Category: Cardiomyopathy]]
[[Category: Overview complete]]
[[Category: Template complete]]
[[Category: Genetic disorders]]


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Revision as of 21:00, 7 August 2011

Hypertrophic Cardiomyopathy Microchapters

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Editors-In-Chief: C. Michael Gibson, M.S., M.D. [1], Martin S. Maron, M.D., and Barry J. Maron, M.D.

Overview

Sudden Cardiac Death

The incidence of sudden cardiac death (SCD) in patients with HCM is 2 to 4 percent per year in adults, and a 4 to 6 percent per year in children and adolescents[1].

Among end stage patients with a left ventricular ejection fraction < 50%, the risk of SCD over 5 years may be as high as 47%. In this population, syncope has been identified as an independent correlate of sudden cardiac death (hazard ratio = 6.15; 95% confidence interval, 2.40-15.75; P < .001)[2].

A review of 78 patients with HCM who died suddenly or survived a cardiac arrest episode showed that 71 percent were younger than 30 years of age, 54 percent were without functional limitation, and 61 percent were performing sedentary or minimal physical activity at the time of cardiac arrest.

Predictors of Sudden Cardiac Death

There are few predictors of SCD in patients with HCM.

Prognosis in Survivors of Sudden Cardiac Death

Survivors of SCD have a poor prognosis. Event free survival at 1,5 and 10 years was 83, 65 and 53 percent respectively.

References

  1. Elliott PM, Poloniecki J, Dickie S, Sharma S, Monserrat L, Varnava A; et al. (2000). "Sudden death in hypertrophic cardiomyopathy: identification of high risk patients". J Am Coll Cardiol. 36 (7): 2212–8. PMID 11127463.
  2. Kawarai H, Kajimoto K, Minami Y, Hagiwara N, Kasanuki H (2011). "Risk of sudden death in end-stage hypertrophic cardiomyopathy". J Card Fail. 17 (6): 459–64. doi:10.1016/j.cardfail.2011.01.015. PMID 21624733.

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