Occupational lung disease causes: Difference between revisions
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===Genetic Causes=== | ===Genetic Causes=== | ||
* | *Occupational lung disease may be triggered by a mutation in the following genes: | ||
**MUC5B promoter polymorphism | |||
***Has been identified as causing progression in interstitial lung fibrosis | |||
**HLA-DPB1*0201 polymorphisms | |||
***Associated with chronic berylliosis, whilst HLA-DPB1*0401 gene is protective | |||
***Single nucleotide polymorphism in the promoter region of TNF-α, the no.308 guanine to adenine transition, has been associated with beryllium sensitization transition to clinial disease | |||
**NAT2 acetylation | |||
***Associated with bladder cancer with exposure to benzine dyes | |||
**HLA class II genes such as HLA-DQB1*0503 | |||
***Associated with toluene diisocyanate-induced occupational asthma | |||
**Polymorphisms in exons 3 of Tyr113His (C113T) and 4 His139Arg (G139A) of the mEH gene | |||
***Associated with organic dust-induced chronic airways disease where the activity of microsomal epoxide hydrolase slows down | |||
===Causes by Organ System=== | ===Causes by Organ System=== | ||
Revision as of 16:10, 13 February 2018
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Occupational lung disease Microchapters |
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Differentiating Occupational lung disease from other Diseases |
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Diagnosis |
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Treatment |
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Occupational lung disease causes On the Web |
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American Roentgen Ray Society Images of Occupational lung disease causes |
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Directions to Hospitals Treating Coalworker's pneumoconiosis |
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Risk calculators and risk factors for Occupational lung disease causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: ;Hadeel Maksoud M.D.[2]
Overview
Occupational lung disease may be caused by organic dust such as thermophilic and true fungi, and bacteria and animal proteins, or by inorganic dust such as, silicates, carbons and metals, or by agents other than organic or inorganic dusts such as, chemicals, gases, fumes, vapors and aerosols.
Causes
Life-threatening Causes
- Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.
- Life-threatening causes of occupational lung disease include asbestos and chemical gas inhalation such as chlorine gas.
Common Causes
Occupational lung disease may be caused by:
- Silica ("silicosis")
- Asbestos ("asbestosis")
- Beryllium ("berylliosis")
- Mica (principally K and Mg aluminum silicates)
- Portland cement
- Aluminum silicates (sericite, sillimanite, zeolite)
- Aluminum
- Hard metal dusts (cadmium, tungsten, titanium and cobalt)
- Iron ("siderosis")
- Coal dust ("coal worker's pneumoconiosis")
- Graphite ("carbon pneumoconiosis")
- Farmer's lung (Macropolyspora faeni)
- Grain handler's lung (Thermactinomyces vulgaris)
- Humidifier or air conditioner lung (T. sacchari)
- Aspergillus
- CuSO4 neutralized with hydrated lime (Bordeaux mixture; "vineyard sprayer's lung")
- Bird fancier's disease
Less Common Causes
Less common causes of occupational lung disease include:
- Vinyl chloride, polyvinyl chloride powder
- Oxygen
- Oxides of nitrogen
- Sulfur dioxide
- Chlorine gas
- Methyl isocyanate
- Oxides of zinc, copper, manganese, cadmium, iron, magnesium, nickel, brass, selenium, tin, and antimony
- Diphenylmethane diisocyanate
- Trimellitic anhydride toxicity
- Hydrocarbons
- Thermosetting resins (rubber tire workers)
- Toluene diisocyanate (TDI - asthmatic reactions prominent)
- Talc (hydrated Mg silicates; "talcosis")
- Kaolin or "china clay" (hydrated aluminum silicate)
- Popcorn worker's lung (butter flavoring)
- Oxygen
- Mercury
- Oils
- Fats
- Pyrethrum (a natural insecticide)
- Nepheline (hard rock containing mixed silicates)
- Diatomaceous earth (Fuller's earth, aluminum silicate with Fe and Mg)
- Tin ("stannosis")
- Antimony
- Hematite(mixed dusts of iron oxide, silica and silicates; "siderosilicosis")
- Mixed dusts of silver and iron oxide ("argyrosiderosis")
- CuSO4 neutralized with hydrated lime (Bordeaux mixture; "vineyard sprayer's lung")
- Rare earths (cerium, scandium, yttrium, lanthanum)
- Cryptostroma corticale
- Aureobasidium pullulans
- Penicillium species
- Bacillus subtilis
- B. cereus
- Synthetic - fiber lung (Orlon, polyesters, nylon, acrylic)
- Bakelite worker's lung pathways
Genetic Causes
- Occupational lung disease may be triggered by a mutation in the following genes:
- MUC5B promoter polymorphism
- Has been identified as causing progression in interstitial lung fibrosis
- HLA-DPB1*0201 polymorphisms
- Associated with chronic berylliosis, whilst HLA-DPB1*0401 gene is protective
- Single nucleotide polymorphism in the promoter region of TNF-α, the no.308 guanine to adenine transition, has been associated with beryllium sensitization transition to clinial disease
- NAT2 acetylation
- Associated with bladder cancer with exposure to benzine dyes
- HLA class II genes such as HLA-DQB1*0503
- Associated with toluene diisocyanate-induced occupational asthma
- Polymorphisms in exons 3 of Tyr113His (C113T) and 4 His139Arg (G139A) of the mEH gene
- Associated with organic dust-induced chronic airways disease where the activity of microsomal epoxide hydrolase slows down
- MUC5B promoter polymorphism
Causes by Organ System
| Cardiovascular | No underlying causes |
| Chemical/Poisoning | No underlying causes |
| Dental | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | No underlying causes |
| Ear Nose Throat | No underlying causes |
| Endocrine | No underlying causes |
| Environmental | No underlying causes |
| Gastroenterologic | No underlying causes |
| Genetic | No underlying causes |
| Hematologic | No underlying causes |
| Iatrogenic | No underlying causes |
| Infectious Disease | No underlying causes |
| Musculoskeletal/Orthopedic | No underlying causes |
| Neurologic | No underlying causes |
| Nutritional/Metabolic | No underlying causes |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | No underlying causes |
| Ophthalmologic | No underlying causes |
| Overdose/Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | No underlying causes |
| Renal/Electrolyte | No underlying causes |
| Rheumatology/Immunology/Allergy | No underlying causes |
| Sexual | No underlying causes |
| Trauma | No underlying causes |
| Urologic | No underlying causes |
| Miscellaneous | No underlying causes |
Causes in Alphabetical Order
List the causes of the disease in alphabetical order.
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