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==Differential diagnosis==
==Differential diagnosis==
{| class="wikitable"
!Disease/Variable
!Presentation
!Causes
!Physical exams findings
!Age commonly affected
!Imaging finding
!Treatment
|-
|[[Peritonsillar abscess]]
|Severe [[sore throat]], [[otalgia]] [[fever]], a "hot potato" or muffled voice, [[drooling]], and [[trismus]]<ref name="pmid18246890" />
|[[Streptococcus pyogenes|Aerobic and anaerobic]]
[[Streptococcus pyogenes|bacteria most common is]]
[[Streptococcus pyogenes|Streptococcus]]
[[Streptococcus pyogenes|pyogenes]].<ref name="pmid15573356" /><ref name="pmid18039418" /><ref name="pmid1875138" /><ref name="pmid12092281" />
|[[Contralateral]] deflection of the uvula,
the [[tonsil]] is displaced [[inferiorly]] and [[medially]], tender [[submandibular]] and [[anterior]] [[cervical lymph nodes|cervical lymph nodes,]] [[Tonsillar abscess|tonsillar]] [[hypertrophy]] with likely peritonsillar [[edema]].
|The highest occurrence is in adults between 20 to 40 years of age.<ref name="pmid18246890" />
|On ultrasound peritonsillar abscess appears as focal irregularly marginated hypoechoic area.<ref name="pmid15635144" /><ref name="pmid1642863" /><ref name="pmid26637999" /><ref name="pmid10435129" /><ref name="pmid15635144" /><ref name="pmid1642863" />
|[[Ampicillin-sulbactam|Ampicillin-sulbactam,]]  [[Clindamycin]], [[Vancomycin]] or [[Linezolid]]
|-
|[[Croup]]
|Has [[cough]] and [[stridor]] but no [[drooling]]. Others are [[Hoarseness]], [[Difficulty breathing]], symptoms of the [[common cold]], [[Runny nose]], [[Fever]]
|[[Parainfluenza virus]]
|Suprasternal and [[intercostal]] [[Indrawing|indrawing,]]<ref name="pmid19445760" /> Inspiratory [[stridor]]<ref name="Cherry2008" />, expiratory [[wheezing]],<ref name="Cherry2008" />  [[Sternal]] wall retractions<ref name="pmid194457602" />
|Mainly 6 months and 3 years old
rarely, adolescents and adults<ref name="pmid8769531" />
|[[Steeple sign]] on neck X-ray
|[[Dexamethasone]] and nebulised [[epenephrine|epinephrine]]
|-
|[[Epiglottitis]]
|Has  [[stridor]] and [[drooling]] [[Difficulty breathing|but no cough. Other symptoms include difficulty breathing]], [[Difficulty swallowing|fever, chills, difficulty swallowing]], [[hoarseness]] of voice
|[[Hemolysis|H. influenza type b,]]
[[Hemolysis|beta-hemolytic]] [[streptococci]], ''[[Staphylococcus aureus]],''
[[fungi]] and [[viruses]].
|[[Cyanosis]], [[Cervical]] [[lymphadenopathy]], Inflammed [[epiglottis]]
|Used to be mostly found in
pediatric age group between 3 to 5 years,
however, recent trend favors adults
as most commonly affected individuals<ref name="pmid270310102" />
with a mean age of 44.94 years
|[[Thumbprint sign]] on neck x-ray
|Airway maintenance, p[[Parenteral|arenteral]] [[Cefotaxime]] or [[Ceftriaxone]] in combination with [[Vancomycin]]. Adjuvant therapy includes [[corticosteroids]] and [[racemic]] [[Epinephrine]].<ref name="pmid15983574" /><ref name="pmid12557859" />
|-
|[[Pharyngitis]]
|[[Sore throat]], pain on swallowing, [[fever]], [[headache]], [[Abdominal pain|abdominal]] pain, [[nausea]] and [[vomiting]]
|[[Group A beta-hemolytic streptococci|Group A beta-hemolytic]]
[[Group A beta-hemolytic streptococci|streptococcus]].
|Inflammed [[pharynx]] with or without [[exudate]]
|Mostly in children and young adults,
with 50% of cases identified
between the ages of 5 to 24 years.<ref name=":0" />
|_
|[[Antimicrobial]] therapy mainly [[penicillin]]-based and [[analgesics]].
|-
|[[Tonsilitis]]
|[[Sore throat]], pain on swallowing, [[fever]], [[headache]], [[cough]]
|Most common cause is
viral including [[adenovirus]],
[[rhinovirus]], [[influenza]],
[[coronavirus]], and
[[respiratory syncytial virus]].
Second most common
causes are bacterial;
''[[Group A streptococcal infection|Group A streptococcal]]''
''[[Group A streptococcal infection|bacteria]]'',<ref name="pmid3601520" />
|[[Fever]], especially 100°F or higher.<ref name="Tonsillitis" /><ref name="urlTonsillitis - NHS Choices" />[[Erythema]], [[edema]] and [[Exudate]] of the [[tonsils]].<ref name="pmid25587367" /> cervical [[lymphadenopathy]], [[Dysphonia]].<ref name="urlTonsillitis - Symptoms - NHS Choices" />
|Primarily affects children
between 5 and 15 years old.<ref name="Oroface" />
|Intraoral or transcutaneous USG may show an abscess making CT scan unnecessary.<ref name="pmid26527518" /><ref name="pmid25946659" /><ref name="pmid25945805" />
|[[Antimicrobial]] therapy mainly [[penicillin]]-based and [[analgesics]] with [[tonsilectomy]] in selected cases.
|-
|[[Retropharyngeal abscess]]
|[[Neck pain]], [[stiff neck]], [[torticollis]]
[[fever]], [[malaise]], [[stridor]], and barking [[cough]]
|Polymicrobial infection.
Mostly; [[Streptococcus pyogenes|Streptococcus]]
[[Streptococcus pyogenes|pyogenes]], [[Staphylococcus aureus]] and respiratory anaerobes (example; Fusobacteria, [[Prevotella species|Prevotella]],
and Veillonella species)<ref name="pmid23520072" /><ref name="pmid22481424" /><ref name="pmid18948832" /><ref name="pmid15573356" /><ref name="pmid18427007" /><ref name="pmid2235179" />
|Child may be unable to open the mouth widely. May have enlarged
[[cervical]] [[lymph nodes]] and neck mass.
|Mostly between 2-4 years, but can occur in other age groups.<ref name="pmid12777558" /><ref name="pmid1876473" />
|On CT scan, a mass impinging on the posterior pharyngeal wall with rim enhancement is seen<ref name="pmid15667676" /><ref name="pmid12761699" />
|Immediate surgical drainage and antimicrobial therapy. emperic therapy involves; [[ampicillin]]-[[sulbactam]] or [[clindamycin]].
|}


==References==
==References==

Revision as of 18:05, 2 March 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Prince Tano Djan, BSc, MBChB [2]

Overview

Differential diagnosis

Disease/Variable Presentation Causes Physical exams findings Age commonly affected Imaging finding Treatment
Peritonsillar abscess Severe sore throat, otalgia fever, a "hot potato" or muffled voice, drooling, and trismus[1] Aerobic and anaerobic

bacteria most common is

Streptococcus

pyogenes.[2][3][4][5]

Contralateral deflection of the uvula,

the tonsil is displaced inferiorly and medially, tender submandibular and anterior cervical lymph nodes, tonsillar hypertrophy with likely peritonsillar edema.

The highest occurrence is in adults between 20 to 40 years of age.[1] On ultrasound peritonsillar abscess appears as focal irregularly marginated hypoechoic area.[6][7][8][9][6][7] Ampicillin-sulbactam, Clindamycin, Vancomycin or Linezolid
Croup Has cough and stridor but no drooling. Others are Hoarseness, Difficulty breathing, symptoms of the common cold, Runny nose, Fever Parainfluenza virus Suprasternal and intercostal indrawing,[10] Inspiratory stridor[11], expiratory wheezing,[11] Sternal wall retractions[12] Mainly 6 months and 3 years old

rarely, adolescents and adults[13]

Steeple sign on neck X-ray Dexamethasone and nebulised epinephrine
Epiglottitis Has stridor and drooling but no cough. Other symptoms include difficulty breathing, fever, chills, difficulty swallowing, hoarseness of voice H. influenza type b,

beta-hemolytic streptococci, Staphylococcus aureus,

fungi and viruses.

Cyanosis, Cervical lymphadenopathy, Inflammed epiglottis Used to be mostly found in

pediatric age group between 3 to 5 years,

however, recent trend favors adults

as most commonly affected individuals[14]

with a mean age of 44.94 years

Thumbprint sign on neck x-ray Airway maintenance, parenteral Cefotaxime or Ceftriaxone in combination with Vancomycin. Adjuvant therapy includes corticosteroids and racemic Epinephrine.[15][16]
Pharyngitis Sore throat, pain on swallowing, fever, headache, abdominal pain, nausea and vomiting Group A beta-hemolytic

streptococcus.

Inflammed pharynx with or without exudate Mostly in children and young adults,

with 50% of cases identified

between the ages of 5 to 24 years.[17]

_ Antimicrobial therapy mainly penicillin-based and analgesics.
Tonsilitis Sore throat, pain on swallowing, fever, headache, cough Most common cause is

viral including adenovirus,

rhinovirus, influenza,

coronavirus, and

respiratory syncytial virus.

Second most common

causes are bacterial;

Group A streptococcal

bacteria,[18]

Fever, especially 100°F or higher.[19][20]Erythema, edema and Exudate of the tonsils.[21] cervical lymphadenopathy, Dysphonia.[22] Primarily affects children

between 5 and 15 years old.[23]

Intraoral or transcutaneous USG may show an abscess making CT scan unnecessary.[24][25][26] Antimicrobial therapy mainly penicillin-based and analgesics with tonsilectomy in selected cases.
Retropharyngeal abscess Neck pain, stiff neck, torticollis

fever, malaise, stridor, and barking cough

Polymicrobial infection.

Mostly; Streptococcus

pyogenes, Staphylococcus aureus and respiratory anaerobes (example; Fusobacteria, Prevotella,

and Veillonella species)[27][28][29][2][30][31]

Child may be unable to open the mouth widely. May have enlarged

cervical lymph nodes and neck mass.

Mostly between 2-4 years, but can occur in other age groups.[32][33] On CT scan, a mass impinging on the posterior pharyngeal wall with rim enhancement is seen[34][35] Immediate surgical drainage and antimicrobial therapy. emperic therapy involves; ampicillin-sulbactam or clindamycin.

References

Template:WH Template:WS