Group A streptococcal infection
Group A streptococcal infection Microchapters
Group A streptcocci or streptoccus pyogenes causes a wide range of diseases in many organs in the body. It is important to classify the infections caused by the bacteria in order to understand every disease separately. Classification of the group A streptococcal infections will be based on the pathogenesis of the infection and the organ infected. According to the pathogenesis of the infection, they can be classified into pyogenic, toxogenic or immunogenic infections. Based on the location, the streptococcus pyogenes affects the lungs, ear, nose, throat, blood, female genital system and the central nervous system.
The pathophysiology of the disease depends on various virulence factors. These factors include protein M, streptolysins O and S, hyalourinidase and C5a peptidase.
Group A streptococcal infections can be classified according to the pathogenesis of the infection and the organ infected. According to the pathogenesis of the infection, they can be classified into pyogenic, toxogenic or immunogenic infections. Based on the location, the streptococcus pyogenes affects the lungs, ear, nose, throat, blood, female genital system and the central nervous system.
|Group A streptococcal infections|
|Pyogenic||Toxogenic||Immunogenic||Lungs||Ear, nose and throat||Bone||Blood||Female genital system||Brain|
|Pharyngitis (Strep throat)||Cellulitis||Impetigo||Erysipelas||Scarlet fever||Toxic shock like syndrome||Necrotizing fasciitis||Rheumatic fever||Glomerulonephritis||Sinusitis||Tonsilitis||Otitis media||Postpartum endometritis||Vaginitis||Meningitis||Brain abscess|
Group A streptococcal infection can be transmitted by the following:
- Direct inoculation transmission
- Infected airborne droplets
Group A streptococcus are responsible for various diseases ranging from mild to life threatening cases. The bacteria depends mainly on many virulence factors which are responsible for the pathogenesis of the infections.
|Virulence factors||Mechanism of action|
|Streptolysin O and S|
|Streptococcal pyrogenic exotoxins A and C|
|Streptococcal chemokine protease||
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