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Lassa fever after an [[incubation period]] of six to twenty-one days, manifest as an acute illness with multiorgan involvement and patients present with [[gastrointestinal]], neurological and [[pulmonary]] symptoms.
Lassa fever after an [[incubation period]] of six to twenty-one days, manifest as an acute illness with multiorgan involvement and patients present with [[gastrointestinal]], neurological and [[pulmonary]] symptoms.


==History and Symptoms==
==Common Symptoms==
 
Common symptoms of Lassa fever are often non-specific symptoms that resemble symptoms of other viral infections:
* [[Fever]]
* [[Headache]]
* [[Malaise]]
* [[Muscle pain]]
* [[Chest pain]]
* [[Weakness]]
* [[Dizziness]]
* [[Sore throat]]
* [[Back pain]]
* [[Cough]]
* [[Nausea]] and [[Vomiting]]
* [[Abdominal pain]]
* [[Diarrhea]] (may be bloody)
* [[Mucosal bleeding]]
* [[Hearing loss]]


<br>
*The following graph demonstrates the common and rare symptoms associated with Lassa fever:
*The following graph demonstrates the common and rare symptoms associated with Lassa fever:
 
[[File:Signs and symptoms Lassa.png|thumb|center|800 px|Signs and symptoms Lassa Fever<SMALL><SMALL>''[http://www.cdc.gov/NCIDOD/dvrd/spb/mnpages/lassaslides.htm]''</SMALL></SMALL>]]
 
[[File:Signs and symptoms Lassa.png|thumb|center|800 px|Symptoms Lassa Fever<SMALL><SMALL>''[http://www.cdc.gov/NCIDOD/dvrd/spb/mnpages/lassaslides.htm]''</SMALL></SMALL>]]
 
==Common Symptoms==
* Because the symptoms of Lassa fever are so varied and nonspecific, clinical diagnosis is often difficult.
* Non-specific symptoms include the following.
:* [[Fever]]-Almost 100%
:* [[Headache]]- 85%
:* [[Muscle fatigue]]- 80%
:* [[Chest pain|Retrosternal pain]] (pain behind the chest wall)-80%
:* [[Weakness]]-77%.
:* [[Dizziness]]-75%
:* [[Sore throat]]-70%
:* [[Back pain]]
:* [[Cough]]-70%
:* [[Vomiting]]-65%
:* [[Abdominal pain]]-60%
:* [[Diarrhea]]-40%
:* Mucosal bleeding-40%
 
==Less Common Symptoms==
==Less Common Symptoms==
The other symptoms arising from the affected organs are:
Less common symptoms of Lassa fever usually develop late and are often associated with a more severe course of disease.
===[[Skin]]===
===[[Skin]]===
*Jaundic
*Jaundic
Line 41: Line 35:
*[[Sore throat]]
*[[Sore throat]]
*[[Facial edema]]
*[[Facial edema]]
*[[Neck swelling]]


===Gastrointestinal tract===
===Gastrointestinal tract===
*[[Hematemesis]]
*[[Hematemesis]]
*[[Diarrhea]] (typically bloody)
*[[Constipation]]
*[[Constipation]]
*[[Dysphagia]]
*[[Dysphagia]]
[[Abdominal pain]]


===Cardiovascular system===
===Cardiovascular system===
*[[Hypotension]] or [[shock]]
*[[Hypotension]] or [[shock]]
*[[Palpitations]]
*[[Palpitations]]
*[[Chest pain]]


===Respiratory tract===
===Respiratory tract===

Revision as of 19:58, 9 June 2015

Lassa fever Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]; Ammu Susheela, M.D. [3]

Synonyms and keywords: Lassa hemorrhagic fever; LHF

Overview

Lassa fever after an incubation period of six to twenty-one days, manifest as an acute illness with multiorgan involvement and patients present with gastrointestinal, neurological and pulmonary symptoms.

Common Symptoms

Common symptoms of Lassa fever are often non-specific symptoms that resemble symptoms of other viral infections:

  • The following graph demonstrates the common and rare symptoms associated with Lassa fever:
Signs and symptoms Lassa Fever[1]

Less Common Symptoms

Less common symptoms of Lassa fever usually develop late and are often associated with a more severe course of disease.

Skin

  • Jaundic

HEENT

Gastrointestinal tract

Cardiovascular system

Respiratory tract

Nervous system

Diagnosis

The current case definition for suspecting Lassa fever is as follows:[1]

Unexplained fever at least 38oC or 100.4oF for one week or more
And 1 of the following:
▸ No response to standard treatment with the choice of regimen for most likely cause of fever (malaria, typhoid fever).
▸ Readmitted within 3 weeks of inpatient care for an illness with fever.
And 1 of the following
Edema or bleeding.
Sore throat and retrosternal pain/vomiting.
▸ Spontaneous abortion following fever.
Hearing loss following fever.

References

  1. "The Centers for Disease Control and Prevention" (PDF).


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