CATAPRES adverse reactions: Difference between revisions
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==Adverse Reactions== | ==Adverse Reactions== | ||
Most adverse effects are mild and tend to diminish with continued therapy. The most frequent (which appear to be dose-related) are dry mouth, occurring in about 40 of 100 patients; drowsiness, about 33 in 100; dizziness, about 16 in 100; constipation and sedation, each about 10 in 100. | |||
The following less frequent adverse experiences have also been reported in patients receiving CATAPRES tablets, but in many cases patients were receiving concomitant medication and a causal relationship has not been established. | |||
===Body as a Whole=== | |||
[[Fatigue]], [[fever]], [[headache]], [[pallor]], weakness, and withdrawal syndrome. Also reported were a weakly positive Coombs’ test and increased sensitivity to alcohol. | |||
===Cardiovascular=== | |||
[[Bradycardia]], [[congestive heart failure]], electrocardiographic abnormalities (i.e., sinus node arrest, [[junctional bradycardia]], high degree [[AV block]] and [[arrhythmias]]), orthostatic symptoms, palpitations, [[Raynaud’s phenomenon]], [[syncope]], and tachycardia. Cases of [[sinus bradycardia]] and [[atrioventricular block]] have been reported, both with and without the use of concomitant [[digitalis]]. | |||
===Central Nervous System=== | |||
[[Agitation]], [[anxiety]], [[delirium]], [[delusional]] perception, [[hallucinations]] (including visual and auditory), [[insomnia]], mental [[depression]], [[nervousness]], other behavioral changes, [[paresthesia]], [[restlessness]], [[sleep disorder]], and vivid dreams or nightmares. | |||
===Dermatological=== | |||
[[Alopecia]], [[angioneurotic edema]], [[hives]], [[pruritus]], [[rash]], and [[urticaria]]. | |||
===Gastrointestinal=== | |||
Abdominal pain, [[anorexia]], [[constipation]], [[hepatitis]], [[malaise]], mild transient abnormalities in liver function tests, [[nausea]], [[parotitis]], pseudo-obstruction (including colonic pseudo-obstruction), salivary gland pain, and [[vomiting]]. | |||
===Genitourinary=== | |||
Decreased sexual activity, difficulty in micturition, erectile dysfunction, loss of libido, nocturia, and urinary retention. | |||
===Hematologic=== | |||
[[Thrombocytopenia]]. | |||
===Metabolic=== | |||
[[Gynecomastia]], transient elevation of blood glucose or serum [[creatine phosphokinase]], and weight gain. | |||
===Musculoskeletal=== | |||
Leg cramps and muscle or joint pain. | |||
===Oro-otolaryngeal=== | |||
Dryness of the nasal mucosa. | |||
===Ophthalmological=== | |||
Accommodation disorder, blurred vision, burning of the eyes, decreased lacrimation, and dryness of eyes.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = CATAPRES (CLONIDINE HYDROCHLORIDE) TABLET [BOEHRINGER INGELHEIM PHARMACEUTICALS INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=d7f569dc-6bed-42dc-9bec-940a9e6b090d | publisher = | date = | accessdate = 5 February 2014 }}</ref> | |||
==References== | ==References== |
Revision as of 05:32, 6 February 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Pratik Bahekar, MBBS [2]
For patient information, click here.
Adverse Reactions
Most adverse effects are mild and tend to diminish with continued therapy. The most frequent (which appear to be dose-related) are dry mouth, occurring in about 40 of 100 patients; drowsiness, about 33 in 100; dizziness, about 16 in 100; constipation and sedation, each about 10 in 100.
The following less frequent adverse experiences have also been reported in patients receiving CATAPRES tablets, but in many cases patients were receiving concomitant medication and a causal relationship has not been established.
Body as a Whole
Fatigue, fever, headache, pallor, weakness, and withdrawal syndrome. Also reported were a weakly positive Coombs’ test and increased sensitivity to alcohol.
Cardiovascular
Bradycardia, congestive heart failure, electrocardiographic abnormalities (i.e., sinus node arrest, junctional bradycardia, high degree AV block and arrhythmias), orthostatic symptoms, palpitations, Raynaud’s phenomenon, syncope, and tachycardia. Cases of sinus bradycardia and atrioventricular block have been reported, both with and without the use of concomitant digitalis.
Central Nervous System
Agitation, anxiety, delirium, delusional perception, hallucinations (including visual and auditory), insomnia, mental depression, nervousness, other behavioral changes, paresthesia, restlessness, sleep disorder, and vivid dreams or nightmares.
Dermatological
Alopecia, angioneurotic edema, hives, pruritus, rash, and urticaria.
Gastrointestinal
Abdominal pain, anorexia, constipation, hepatitis, malaise, mild transient abnormalities in liver function tests, nausea, parotitis, pseudo-obstruction (including colonic pseudo-obstruction), salivary gland pain, and vomiting.
Genitourinary
Decreased sexual activity, difficulty in micturition, erectile dysfunction, loss of libido, nocturia, and urinary retention.
Hematologic
Metabolic
Gynecomastia, transient elevation of blood glucose or serum creatine phosphokinase, and weight gain.
Musculoskeletal
Leg cramps and muscle or joint pain.
Oro-otolaryngeal
Dryness of the nasal mucosa.
Ophthalmological
Accommodation disorder, blurred vision, burning of the eyes, decreased lacrimation, and dryness of eyes.[1]
References
- ↑ "CATAPRES (CLONIDINE HYDROCHLORIDE) TABLET [BOEHRINGER INGELHEIM PHARMACEUTICALS INC.]". Retrieved 5 February 2014.