Herpes simplex treatment: Difference between revisions
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==Other drugs== | ==Other drugs== | ||
[[Cimetidine]], | |||
'''1)''' [[Cimetidine]], commonly used in [[heartburn]], has been shown to lessen the severity of [[herpes zoster]] outbreaks in several different instances, and offered some relief from herpes simplex.<ref name=kapinska> | |||
{{cite journal | |||
| author=Kapinska-Mrowiecka M, Toruwski G | title=Efficacy of cimetidine in treatment of herpes zoster in the first 5 days from the moment of disease manifestation. | journal= Pol Tyg Lek. | year=1996. | pages=338-339 | volume=51 | issue=23-26 | id=PMID 9273526 | '''2)''' Vaseline, or any other type of fat prevents water, or saliva, from reaching the cold sore. Since, the cold sore needs water to sustain itself, this will end its existence in a day or two. | ||
}}</ref><ref name=hayne> | {{cite journal | author=Kapinska-Mrowiecka M, Toruwski G | title=Efficacy of cimetidine in treatment of herpes zoster in the first 5 days from the moment of disease manifestation. | journal= Pol Tyg Lek. | year=1996. | pages=338-339 | volume=51 | issue=23-26 | id=PMID 9273526}}</ref><ref name=hayne> {{cite journal | author=Hayne ST, Mercer JB | title=Herpes zoster:treatment with cemetidine. | journal=Can Med Assoc J | year= 1983 | pages=1284-1285 | volume=129 | issue=12 | id=PMID 6652595}}</ref><ref name=komlos> | ||
{{cite journal | {{cite journal | author=Komlos L, Notmann J, Arieli J, et.al. | title=In vitro cell-mediated immune reactions in herpes zoster patients treated with cimetidine. | journal=Asian Pac J Allelrgy Immunol | year= 1994 | pages=51-58 | volume=12 | issue=1 | id=PMID 7872992 | ||
| author=Hayne ST, Mercer JB | title=Herpes zoster:treatment with cemetidine. | journal=Can Med Assoc J | year= 1983 | pages=1284-1285 | volume=129 | issue=12 | id=PMID 6652595 | }}</ref> This is an [[off-label use]] of the drug. It and [[probenecid]] have been shown to reduce the [[Clearance (medicine)|renal clearance]] of aciclovir.<ref name=debony> | ||
}}</ref><ref name=komlos> | |||
{{cite journal | |||
| author=Komlos L, Notmann J, Arieli J, et.al. | title=In vitro cell-mediated immune reactions in herpes zoster patients treated with cimetidine. | journal=Asian Pac J Allelrgy Immunol | year= 1994 | pages=51-58 | volume=12 | issue=1 | id=PMID 7872992 | |||
}} | |||
</ref> This is an [[off-label use]] of the drug. It and [[probenecid]] have been shown to reduce the [[Clearance (medicine)|renal clearance]] of aciclovir.<ref name=debony> | |||
{{cite journal | {{cite journal | ||
| author=De Bony F, Tod M, Bidault R, On NT, Posner J, Rolan P. | title=Multiple interactions of cimetidine and probenecid with valaciclovir and its metabolite acyclovir | journal=Antimicrob. Agents Chemother. | year=2002 | pages=458-463 | volume=46 | issue=2 | id=PMID 11796358 | | author=De Bony F, Tod M, Bidault R, On NT, Posner J, Rolan P. | title=Multiple interactions of cimetidine and probenecid with valaciclovir and its metabolite acyclovir | journal=Antimicrob. Agents Chemother. | year=2002 | pages=458-463 | volume=46 | issue=2 | id=PMID 11796358 | ||
}}</ref> These compounds also reduce the rate, but not the extent, at which valaciclovir is converted into aciclovir. | }}</ref> These compounds also reduce the rate, but not the extent, at which valaciclovir is converted into aciclovir. | ||
Limited evidence suggests that low dose [[aspirin]] (125 mg daily) might be beneficial in patients with recurrent HSV infections. | '''3)''' Limited evidence suggests that low dose [[aspirin]] (125 mg daily) might be beneficial in patients with recurrent HSV infections. It reduces the level of [[prostaglandin]]s that are mediators of [[inflammation]].<ref name=Karadi> | ||
{{cite journal | {{cite journal | ||
| author=Karadi I, Karpati S, Romics L. | title=Aspirin in the management of recurrent herpes simplex virus infection | journal=Ann. Intern. Med. | year=1998 | pages=696-697 | volume=128 | issue=8 | id=PMID 9537952 | | author=Karadi I, Karpati S, Romics L. | title=Aspirin in the management of recurrent herpes simplex virus infection | journal=Ann. Intern. Med. | year=1998 | pages=696-697 | volume=128 | issue=8 | id=PMID 9537952 | ||
}}</ref> A recent study in animals showed inhibition of thermal (heat) [[Stress (medicine)|stress]]-induced [[viral shedding]] of HSV-1 in the eye by aspirin, and a possible benefit in reducing the frequency of recurrences.<ref name=Gebhardt> | }}</ref> | ||
'''4)''' A recent study in animals showed inhibition of thermal (heat) [[Stress (medicine)|stress]]-induced [[viral shedding]] of HSV-1 in the eye by aspirin, and a possible benefit in reducing the frequency of recurrences.<ref name=Gebhardt> | |||
{{cite journal | {{cite journal | ||
Revision as of 22:54, 15 September 2011
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Herpes simplex treatment On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]
Overview
Currently, there is no treatment that can eradicate any of the herpes viruses from the body. Non-prescription analgesics can reduce pain and fever during initial outbreaks. Topical anesthetic treatment (such as prilocaine, lidocaine or tetracaine) can relieve itching and pain.[1][2]
Antiviral Therapy
Topical treatments
Docosanol
- Docosanol prevents herpes simplex virus from fusing to cell membranes, thus barring the entry of the virus into the skin.
- It was approved for use after clinical trials by the FDA in July 2000.[3]
- It was the first over-the-counter antiviral drug approved for sale in the United States and Canada
Tromantadine
- Tromantadine is available as a gel that inhibits entry and spreading of the virus by altering the surface composition of skin cells and inhibiting release of viral genetic material.
Zilactin
- It is a topical analgesic barrier treatment, which forms a "shield" at the area of application to prevents a sore from increasing in size and decrease viral spreading during the healing process.
Other drugs
1) Cimetidine, commonly used in heartburn, has been shown to lessen the severity of herpes zoster outbreaks in several different instances, and offered some relief from herpes simplex.[4][5][6] This is an off-label use of the drug. It and probenecid have been shown to reduce the renal clearance of aciclovir.[7] These compounds also reduce the rate, but not the extent, at which valaciclovir is converted into aciclovir.
3) Limited evidence suggests that low dose aspirin (125 mg daily) might be beneficial in patients with recurrent HSV infections. It reduces the level of prostaglandins that are mediators of inflammation.[8]
4) A recent study in animals showed inhibition of thermal (heat) stress-induced viral shedding of HSV-1 in the eye by aspirin, and a possible benefit in reducing the frequency of recurrences.[9]
References
- ↑ "Local anesthetic creams". BMJ. 297 (6661): 1468. 1988. PMID 3147021.
- ↑ Kaminester LH, Pariser RJ, Pariser DM; et al. (1999). "A double-blind, placebo-controlled study of topical tetracaine in the treatment of herpes labialis". J. Am. Acad. Dermatol. 41 (6): 996–1001. PMID 10570387.
- ↑ "Drug Name: ABREVA (docosanol) - approval". centerwatch.com. July 2000. Retrieved 2007-10-17.
- ↑
2) Vaseline, or any other type of fat prevents water, or saliva, from reaching the cold sore. Since, the cold sore needs water to sustain itself, this will end its existence in a day or two.
Kapinska-Mrowiecka M, Toruwski G (1996.). "Efficacy of cimetidine in treatment of herpes zoster in the first 5 days from the moment of disease manifestation". Pol Tyg Lek. 51 (23–26): 338–339. PMID 9273526. Check date values in:
|year=(help) - ↑ Hayne ST, Mercer JB (1983). "Herpes zoster:treatment with cemetidine". Can Med Assoc J. 129 (12): 1284–1285. PMID 6652595.
- ↑ Komlos L, Notmann J, Arieli J, et.al. (1994). "In vitro cell-mediated immune reactions in herpes zoster patients treated with cimetidine". Asian Pac J Allelrgy Immunol. 12 (1): 51–58. PMID 7872992.
- ↑ De Bony F, Tod M, Bidault R, On NT, Posner J, Rolan P. (2002). "Multiple interactions of cimetidine and probenecid with valaciclovir and its metabolite acyclovir". Antimicrob. Agents Chemother. 46 (2): 458–463. PMID 11796358.
- ↑ Karadi I, Karpati S, Romics L. (1998). "Aspirin in the management of recurrent herpes simplex virus infection". Ann. Intern. Med. 128 (8): 696–697. PMID 9537952.
- ↑ Gebhardt BM, Varnell ED, Kaufman HE. (2004). "Acetylsalicylic acid reduces viral shedding induced by thermal stress". Curr. Eye Res. 29 (2–3): 119–125. PMID 15512958.