Aortic stenosis symptoms: Difference between revisions

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===Syncope===
===Syncope===
The mechanism of [[syncope]] secondary to [[aortic stenosis]] remains unclear. Left untreated, the average survival is 3 years after the onset of syncope in the patient with aortic stenosis.
The mechanism of [[syncope]] secondary to [[aortic stenosis]] remains unclear. Left untreated, the average survival is 3 years after the onset of syncope in the patient with aortic stenosis.
Three theories have been hypothesized to explain the relationship between [[aortic stenosis]] and [[syncope]]:
Three theories have been hypothesized to explain the relationship between [[aortic stenosis]] and [[syncope]]:<ref>{{Cite journal
| author = [[S. Frank]], [[A. Johnson]] & [[J. Jr Ross]]
| title = Natural history of valvular aortic stenosis
| journal = [[British heart journal]]
| volume = 35
| issue = 1
| pages = 41–46
| year = 1973
| month = January
| pmid = 4685905
}}</ref>


*Severe aortic stenosis results in a nearly fixed cardiac output. During exercise, the [[peripheral vascular resistance]] will decrease as the blood vessels dilate to allow the [[skeletal muscles]] to receive more blood. This decrease in peripheral vascular resistance is normally compensated by an increase in the [[cardiac output]]. Since patients with severe [[aortic stenosis]] cannot increase their cardiac output, the blood pressure falls and the patient will develop [[syncope]] due to decreased blood flow to the [[brain]].
*Severe aortic stenosis results in a nearly fixed cardiac output. During exercise, the [[peripheral vascular resistance]] will decrease as the blood vessels dilate to allow the [[skeletal muscles]] to receive more blood. This decrease in peripheral vascular resistance is normally compensated by an increase in the [[cardiac output]]. Since patients with severe [[aortic stenosis]] cannot increase their cardiac output, the blood pressure falls and the patient will develop [[syncope]] due to decreased blood flow to the [[brain]].

Revision as of 20:32, 15 December 2016



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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Mohammed A. Sbeih, M.D. [2]; Lakshmi Gopalakrishnan, M.B.B.S. [3]; Assistant Editor-In-Chief: Kristin Feeney, B.S. [4]

Overview

The main symptoms of aortic stenosis are angina, syncope, and congestive heart failure. Left untreated, the average survival is 5 years after the onset of angina, 3 years after the onset of syncope, and 1 year after the onset of congestive heart failure.[1][2][3] Other symptoms of aortic stenosis are dyspnea on exertion, orthopnea and paroxysmal nocturnal dyspnea.[4]

Symptoms

Symptoms by Age Group

Symptoms in Adults

Symptoms in Infants and Children

Angina Pectoris

  • The hypertrophied left ventricle and the prolonged ejection time (the time for the heart to eject blood) result in an increased myocardial oxygen requirements. The elevated diastolic filling pressure also reduces the gradient between the aorta and the right atrium ("the height of the waterfall") which normally drives coronary blood flow. The hypertrophied ventricle may also compress the capillaries. All of the above reasons lead to a reduction in coronary blood flow even in the absence of obstructive epicardial stenoses. This may result in subendocardial ischemia during stress or exercise.[5][6]
  • Left untreated, the average survival is 5 years after the onset of angina in the patient with aortic stenosis.

Syncope

The mechanism of syncope secondary to aortic stenosis remains unclear. Left untreated, the average survival is 3 years after the onset of syncope in the patient with aortic stenosis. Three theories have been hypothesized to explain the relationship between aortic stenosis and syncope:[7]

  • Severe aortic stenosis results in a nearly fixed cardiac output. During exercise, the peripheral vascular resistance will decrease as the blood vessels dilate to allow the skeletal muscles to receive more blood. This decrease in peripheral vascular resistance is normally compensated by an increase in the cardiac output. Since patients with severe aortic stenosis cannot increase their cardiac output, the blood pressure falls and the patient will develop syncope due to decreased blood flow to the brain.
  • During exercise, the high pressures generated in the hypertrophied left ventricle may cause a vasodepressor response, which subsequently results in peripheral vasodilation. As a consequence, the blood flow to the brain may decrease. Therefore, due to the fixed outwards blood flow obstruction at the level of the stenosed aortic valve, it may be impossible for the heart to increase its output to offset the peripheral vasodilation.

Congestive Heart Failure

CHF in the setting of aortic stenosis is due to a combination of systolic dysfunction (a decrease in the ejection fraction) and diastolic dysfunction (elevated filling pressure of the left ventricle). Left untreated, the average survival is 5 years after the onset of angina, 3 years after the onset of syncope, and 1 year after the onset of congestive heart failure. [1][2][3]

Symptoms of left ventricular failure include the following:

References

  1. 1.0 1.1 Ross J, Braunwald E (1968). "Aortic stenosis". Circulation. 38 (1 Suppl): 61–7. PMID 4894151.
  2. 2.0 2.1 Kelly TA, Rothbart RM, Cooper CM, Kaiser DL, Smucker ML, Gibson RS (1988). "Comparison of outcome of asymptomatic to symptomatic patients older than 20 years of age with valvular aortic stenosis". Am J Cardiol. 61 (1): 123–30. PMID 3337000.
  3. 3.0 3.1 Iivanainen AM, Lindroos M, Tilvis R, Heikkilä J, Kupari M (1996). "Natural history of aortic valve stenosis of varying severity in the elderly". Am J Cardiol. 78 (1): 97–101. PMID 8712130.
  4. J. F. Spann, A. A. Bove, G. Natarajan & T. Kreulen (1980). "Ventricular performance, pump function and compensatory mechanisms in patients with aortic stenosis". Circulation. 62 (3): 576–582. PMID 6446989. Unknown parameter |month= ignored (help)
  5. Marcus ML, Doty DB, Hiratzka LF, Wright CB, Eastham CL (1982). "Decreased coronary reserve: a mechanism for angina pectoris in patients with aortic stenosis and normal coronary arteries". N Engl J Med. 307 (22): 1362–6. doi:10.1056/NEJM198211253072202. PMID 6215582.
  6. Carabello BA (2002). "Clinical practice. Aortic stenosis". N Engl J Med. 346 (9): 677–82. doi:10.1056/NEJMcp010846. PMID 11870246.
  7. S. Frank, A. Johnson & J. Jr Ross (1973). "Natural history of valvular aortic stenosis". British heart journal. 35 (1): 41–46. PMID 4685905. Unknown parameter |month= ignored (help)

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