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{{CMG}} '''Assosciate Editor(s)-In-Chief:''' [[User: Prashanthsaddala|Prashanth Saddala M.B.B.S]] | __NOTOC__ | ||
{{CMG}} '''Assosciate Editor(s)-In-Chief:''' [[User: Prashanthsaddala|Prashanth Saddala M.B.B.S]]{{Homa}} | |||
{{VIPoma (patient information)}} | {{VIPoma (patient information)}} | ||
'''For the WikiDoc page for this topic, click [[VIPoma|here]].''' | '''For the WikiDoc page for this topic, click [[VIPoma|here]].''' | ||
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==Overview== | ==Overview== | ||
VIPoma is a very rare type of cancer that usually grows from cells in the [[pancreas]] called [[islet cell]]s. | VIPoma is a very [[rare]] type of [[cancer]] that usually [[Growth|grows]] from [[Cells (biology)|cells]] in the [[pancreas]] called [[islet cell]]s. | ||
==What are the symptoms of VIPoma ?== | ==What are the symptoms of VIPoma ?== | ||
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* [[Abdominal pain]] and [[cramping]] | * [[Abdominal pain]] and [[cramping]] | ||
* [[Diarrhea]] (watery, and often in large amounts) | * [[Diarrhea]] (watery, and often in large amounts) | ||
* [[Flushing]] or redness of the face | * [[Flushing]] or [[redness]] of the [[face]] | ||
* [[Nausea]] | * [[Nausea]] | ||
* [[Weight loss]] | * [[Weight loss]] | ||
==What causes VIPoma ?== | ==What causes VIPoma ?== | ||
VIPoma causes cells in the pancreas to produce high levels of a hormone called vasoactive intestinal peptide (VIP). This hormone increases secretions from the [[intestine]]s and relaxes some of the [[smooth muscle]]s in the GI system. | VIPoma causes [[Cells (biology)|cells]] in the [[pancreas]] to produce high levels of a [[hormone]] called [[vasoactive intestinal peptide]] ([[Vasoactive intestinal peptide|VIP]]). This [[hormone]] increases [[secretions]] from the [[intestine]]s and relaxes some of the [[smooth muscle]]s in the [[Gastrointestinal tract|GI]] [[system]]. | ||
The cause is not known. | The [[Causes|cause]] is not known. | ||
==Who is at highest risk?== | ==Who is at highest risk?== | ||
VIPomas are usually diagnosed in adults, most commonly at age 50. Women are more likely to be affected than men. This cancer is rare, affecting an estimated 1 in 10 million people per year. | [[VIPoma|VIPomas]] are usually [[Diagnose|diagnosed]] in [[Adult|adults]], most commonly at [[age]] 50. [[Women]] are more likely to be affected than [[men]]. This [[cancer]] is [[rare]], affecting an [[Estimate|estimated]] 1 in 10 million people per [[year]]. | ||
==Diagnosis== | ==Diagnosis== | ||
Signs may include: | [[Signs]] may include: | ||
* [[Dehydration]] | * [[Dehydration]] | ||
* High volume of [[diarrhea]] (even without eating) | * High [[volume]] of [[diarrhea]] (even without [[eating]]) | ||
* Low stomach acid ([[achlorhydria]]) | * Low [[stomach acid]] ([[achlorhydria]]) | ||
* Low blood [[potassium]] [[hypokalemia]], which can cause leg cramps | * Low [[blood]] [[potassium]] [[hypokalemia]], which can [[Causes|cause]] [[leg cramps]] | ||
Tests include: | Tests include: | ||
* Blood chemistry tests (basic or [[comprehensive metabolic panel]]) | *[[Blood chemistry tests]] ([[Basic (chemistry)|basic]] or [[comprehensive metabolic panel]]) | ||
* [[CT scan of the abdomen]] | *[[Computed tomography|CT scan]] of the [[abdomen]] | ||
* [[MRI of the abdomen]] | *[[Magnetic resonance imaging|MRI]] of the [[abdomen]] | ||
* Stool examination for cause of [[diarrhea]] and [[electrolyte]] levels | *[[Stool examination]] for [[Causes|cause]] of [[diarrhea]] and [[electrolyte]] levels | ||
* [[Vasoactive intestinal peptide]] (VIP) level in the blood | * [[Vasoactive intestinal peptide]] ([[Vasoactive intestinal peptide|VIP]]) level in the [[blood]] | ||
==When to seek urgent medical care?== | ==When to seek urgent medical care?== | ||
Call your [[health care provider]] if: | |||
*You develop [[Symptom|symptoms]] of [[VIPoma]] | |||
==Treatment options== | ==Treatment options== | ||
* The first goal of treatment is to correct [[dehydration]]. | |||
*[[Fluids]] are often given through a [[vein]] ([[intravenous fluids]]) to replace [[fluids]] lost in [[diarrhea]]. | |||
* The next goal is to [[slow]] the [[diarrhea]]. | |||
** Some [[medications]] can help [[control]] [[diarrhea]]. | |||
**[[Octreotide]], which is a human-made form of a natural [[hormone]], blocks the action of [[Vasoactive intestinal peptide|VIP]]. | |||
The | * The best [[chance]] for a [[cure]] is [[surgery]] to remove the [[tumor]]. If the [[tumor]] has not spread to other [[organs]], [[surgery]] can often [[cure]] the [[condition]]. | ||
==Where to find medical care for VIPoma ?== | ==Where to find medical care for VIPoma ?== | ||
[[Medical care]] for VIPoma can be found [https://www.google.com/maps/search/hospitals/ here]. | |||
==Prevention of VIPoma== | ==Prevention of VIPoma== | ||
There are no established [[Preventive care|preventive]] measures for VIPoma | |||
==What to expect (Outlook/Prognosis)?== | ==What to expect (Outlook/Prognosis)?== | ||
Surgery can usually cure VIPomas. However, in one-third to one-half of patients, the tumor has spread by the time of diagnosis and cannot be cured. | [[Surgery]] can usually [[cure]] VIPomas. However, in one-third to one-half of [[patients]], the [[tumor]] has spread by the time of [[diagnosis]] and cannot be [[Cure|cured]]. | ||
==Possible complications== | ==Possible complications== | ||
* Cancer spread ([[metastasis]]) | *[[Cancer]] spread ([[metastasis]]) | ||
* Cardiac arrest from low blood | *[[Cardiac arrest]] from [[low blood potassium]] level | ||
* [[Dehydration]] | * [[Dehydration]] | ||
==Sources== | ==Sources== | ||
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001275/ | http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001275/ | ||
[[Category:Up-To-Date]] | |||
[[Category:Oncology]] | |||
[[Category:Medicine]] | |||
[[Category:Gastroenterology]] | |||
[[Category:Surgery]] | |||
Latest revision as of 18:13, 12 September 2019
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Assosciate Editor(s)-In-Chief: Prashanth Saddala M.B.B.S Homa Najafi, M.D.[2]
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VIPoma |
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VIPoma On the Web |
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For the WikiDoc page for this topic, click here.
Overview
VIPoma is a very rare type of cancer that usually grows from cells in the pancreas called islet cells.
What are the symptoms of VIPoma ?
- Abdominal pain and cramping
- Diarrhea (watery, and often in large amounts)
- Flushing or redness of the face
- Nausea
- Weight loss
What causes VIPoma ?
VIPoma causes cells in the pancreas to produce high levels of a hormone called vasoactive intestinal peptide (VIP). This hormone increases secretions from the intestines and relaxes some of the smooth muscles in the GI system.
The cause is not known.
Who is at highest risk?
VIPomas are usually diagnosed in adults, most commonly at age 50. Women are more likely to be affected than men. This cancer is rare, affecting an estimated 1 in 10 million people per year.
Diagnosis
Signs may include:
- Dehydration
- High volume of diarrhea (even without eating)
- Low stomach acid (achlorhydria)
- Low blood potassium hypokalemia, which can cause leg cramps
Tests include:
- Blood chemistry tests (basic or comprehensive metabolic panel)
- CT scan of the abdomen
- MRI of the abdomen
- Stool examination for cause of diarrhea and electrolyte levels
- Vasoactive intestinal peptide (VIP) level in the blood
When to seek urgent medical care?
Call your health care provider if:
Treatment options
- The first goal of treatment is to correct dehydration.
- Fluids are often given through a vein (intravenous fluids) to replace fluids lost in diarrhea.
- The next goal is to slow the diarrhea.
- Some medications can help control diarrhea.
- Octreotide, which is a human-made form of a natural hormone, blocks the action of VIP.
- The best chance for a cure is surgery to remove the tumor. If the tumor has not spread to other organs, surgery can often cure the condition.
Where to find medical care for VIPoma ?
Medical care for VIPoma can be found here.
Prevention of VIPoma
There are no established preventive measures for VIPoma
What to expect (Outlook/Prognosis)?
Surgery can usually cure VIPomas. However, in one-third to one-half of patients, the tumor has spread by the time of diagnosis and cannot be cured.
Possible complications
- Cancer spread (metastasis)
- Cardiac arrest from low blood potassium level
- Dehydration