Diffuse large B cell lymphoma biopsy: Difference between revisions

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Latest revision as of 03:40, 20 June 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2] Anila Hussain, MD [3]

Overview

Excisional Lymph node or extranodal tissue biopsy is diagnostic of diffuse large B cell lymphoma.

Biopsy

Surgical Excision Biopsy of Lymph node or extranodal tissue is diagnostic of diffuse large B cell lymphoma.^[1]
Needle-Core Excision and Endoscopic Biopsies should be reserved for patients in which surgery is too risky or impractical.
FNA not used for diagnosis alone.
To view findings on biopsy characteristic of each morphological variant of diffuse large B cell lymphoma, click here.
morphological Diagnosis of DLBCL on Biopsy should always be confirmed by Immunophenotypic techniques like Flow cytometry or IHC or Both.

References

↑ National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov

Template:WikiDoc Sources

[”seer”-1] National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov

[1]

@@ Line 1: / Line 1: @@
 __NOTOC__
 {{Diffuse large B cell lymphoma}}
-{{CMG}}
+{{CMG}}; {{AE}} {{AS}} {{AHS}}
 ==Overview==
-Biopsy is diagnostic of large B cell lymphoma.
+Excisional Lymph node or extranodal tissue biopsy is diagnostic of diffuse large B cell lymphoma.
 ==Biopsy==
-Biopsy is diagnostic of large B cell lymphoma.
+*Surgical Excision Biopsy of Lymph node or extranodal tissue is diagnostic of diffuse large B cell lymphoma.<ref name="”seer”">National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov</ref>
+*Needle-Core Excision and Endoscopic Biopsies should be reserved for patients in which surgery is too risky or impractical.
-==Microscopic Pathology==
+*FNA not used for diagnosis alone.
-{| align="right"
+*To view findings on biopsy characteristic of each morphological variant of diffuse large B cell lymphoma, click [[Diffuse large B cell lymphoma pathophysiology #Microscopic Pathology|'''here''']].
-|-valign="top"
+*morphological Diagnosis of DLBCL on Biopsy should always be confirmed by Immunophenotypic techniques like Flow cytometry or IHC or Both.
-| [[Image:215px-diffuse large B cell lymphoma - cytology low mag.jpg|thumb|350px|Micrograph of a diffuse large B cell lymphoma]]
-|}
-<br clear="left"/>
-* Three variants are most commonly seen: centroblastic, immunoblastic, and anaplastic.
-===Centroblastic===
-* Most cases of  are diffuse large B cell lymphoma centroblastic, having the appearance of medium-to-large-sized [[lymphocyte]]s with scanty [[cytoplasm]].
-* Oval or round [[Cell nucleus|nuclei]] containing fine [[chromatin]] are prominently visible, having two to four [[nucleoli]] within each nucleus.
-* Sometimes the tumour may be monomorphic, composed almost entirely of centroblasts.
-* However, most cases are polymorphic, with a mixture of centroblastic and immunoblastic cells.
-===Immunoblastic===
-* Immunoblasts have significant [[basophilic]] cytoplasm and a central nucleolus.
-* A tumour can be classified as immunoblastic if greater than 90% of its cells are immunoblasts. This distinction can be problematic, however, because hematopathologists reviewing the microscope slides may often disagree on whether a collection of cells is best characterized as centroblasts or immunoblasts.<ref name="Harris1994">{{cite journal |pmid=8068936 |year=1994 |last1=Harris |first1=N. L. |title=A revised European-American classification of lymphoid neoplasms: A proposal from the International Lymphoma Study Group |journal=Blood |volume=84 |issue=5 |pages=1361–92 |last2=Jaffe |first2=E. S. |last3=Stein |first3=H |last4=Banks |first4=P. M. |last5=Chan |first5=J. K. |last6=Cleary |first6=M. L. |last7=Delsol |first7=G |last8=De Wolf-Peeters |first8=C |last9=Falini |first9=B |last10=Gatter |first10=K. C. |url=http://www.bloodjournal.org/content/84/5/1361 }}</ref> Such disagreement indicates poor [[inter-rater reliability]].
-===Anaplastic===
-* The third morphologic variant, [[Anaplasia|anaplastic]], consists of tumour cells which appear very differently from their normal B cell counterparts.
-* The cells are generally very large with a round, oval, or polygonal shape and pleomorphic nuclei, and may resemble [[Hodgkin's lymphoma#Pathology|Hodgkin cells]] or reed–Sternberg cell.
 ==References==
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 {{WikiDoc Sources}}
+ [[Category:Up-To-Date]]
+[[Category:Oncology]]
+[[Category:Medicine]]
+[[Category:Hematology]]
+[[Category:Immunology]]

Diffuse large B cell lymphoma biopsy: Difference between revisions

Latest revision as of 03:40, 20 June 2018

Overview

Biopsy

References

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