Sjögren's syndrome CT

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]


Parotid gland CT scan may be helpful in the diagnosis of Sjögren's syndrome and finding include abnormal diffuse fat tissue deposition and diffuse punctate calcification.


CT scan showing bilateral parotid swellingsource:Case courtesy of Medical Doctor Oscar Miguel Vila Nieto,, rID: 37196

  • Chest CT scan may be helpful in the diagnosis of complications of Sjögren's syndrome, which include:[4][5][6][2][7][8]
    • Nonspecific interstitial pneumonia
      • Patchy ground-glass attenuation
      • Intralobular reticulation with a lower lobe predilection
    • Interstitial pneumonia pattern
      • Increased reticular markings in a basilar and peripheral distribution
      • Areas of subpleural honeycombing
    • lymphoid interstitial pneumonia pattern
      • Ground-glass attenuation
      • Centrilobular and subpleural nodules
      • Septal thickening
      • Reticular opacities
      • Bronchial/bronchiolar thickening
      • Thin-walled cysts
    • Nodular lymphoid hyperplasia
      • Nodular or mass-like consolidation with or without air bronchogram
    • Follicular bronchiolitis
      • Centrilobular and peribronchial nodules
    • Organizing pneumonia
      • Consolidative and ground-glass opacities
      • Centrilobular nodules and tree-in-bud opacities
    • Pulmonary nodular amyloidosis
      • Diffuse nodules
      • Cystic lesions
      • Focal consolidation
      • Diffuse septal thickening
CT scan showing Lymphocytic-interstitial-pneumoniasource:Case courtesy of Dr Charlie Chia-Tsong Hsu,, rID: 23845


  1. Sun Z, Zhang Z, Fu K, Zhao Y, Liu D, Ma X (October 2012). "Diagnostic accuracy of parotid CT for identifying Sjögren's syndrome". Eur J Radiol. 81 (10): 2702–9. doi:10.1016/j.ejrad.2011.12.034. PMID 22285605.
  2. 2.0 2.1 Gupta N, Wikenheiser-Brokamp KA, Fischer A, McCormack FX (March 2016). "Diffuse Cystic Lung Disease as the Presenting Manifestation of Sjögren Syndrome". Ann Am Thorac Soc. 13 (3): 371–5. doi:10.1513/AnnalsATS.201511-759BC. PMC 5461998. PMID 26741500.
  3. Matsuyama N, Ashizawa K, Okimoto T, Kadota J, Amano H, Hayashi K (December 2003). "Pulmonary lesions associated with Sjögren's syndrome: radiographic and CT findings". Br J Radiol. 76 (912): 880–4. doi:10.1259/bjr/18937619. PMID 14711775.
  4. Song MK, Seol YM, Park YE, Kim YS, Lee MK, Lee CH, Jeong YJ (September 2007). "Pulmonary nodular lymphoid hyperplasia associated with Sjögren's syndrome". Korean J. Intern. Med. 22 (3): 192–6. PMC 2687695. PMID 17939337.
  5. Kokosi M, Riemer EC, Highland KB (September 2010). "Pulmonary involvement in Sjögren syndrome". Clin. Chest Med. 31 (3): 489–500. doi:10.1016/j.ccm.2010.05.007. PMID 20692541.
  6. Panchabhai TS, Farver C, Highland KB (September 2016). "Lymphocytic Interstitial Pneumonia". Clin. Chest Med. 37 (3): 463–74. doi:10.1016/j.ccm.2016.04.009. PMID 27514593.
  7. Taouli B, Brauner MW, Mourey I, Lemouchi D, Grenier PA (June 2002). "Thin-section chest CT findings of primary Sjögren's syndrome: correlation with pulmonary function". Eur Radiol. 12 (6): 1504–11. doi:10.1007/s00330-001-1236-7. PMID 12042961.
  8. Uffmann M, Kiener HP, Bankier AA, Baldt MM, Zontsich T, Herold CJ (October 2001). "Lung manifestation in asymptomatic patients with primary Sjögren syndrome: assessment with high resolution CT and pulmonary function tests". J Thorac Imaging. 16 (4): 282–9. PMID 11685093.