Precocious puberty causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Amira Albawri M.D.
Overview
Central precocious puberty may be caused by either
Central Precocious Puberty , Peripheral Precocious Puberty , or genetic .
Causes
Central Precocious Puberty
If the cause can be traced to the hypothalamus or pituitary, the cause is considered central.
Causes can include:
- Damage to the inhibitory system of the brain (due to infection, trauma, or irradiation)
- hypothalamic hamartoma produces pulsatile gonadotropin-releasing hormone (GnRH)
- Langerhans cell histiocytosis
- McCune-Albright syndrome
- Intracranial neoplasm
- Hydrocephalus
- Angelman syndrome[1]
- Suprasellar arachnoid cysts(SAC)
- Recurrent seizures
- Idiopathic disease[2]
Bones can be considered older in individuals with early puberty. Early puberty is marked by growth hormone problems resulting from various brain disorders.
If no cause can be identified, it is considered idiopathic or constitutional.
Peripheral Precocious Puberty
Causes can include:
- Endogenous sources
- Gonadal tumors (such as arrhenoblastoma)
- Adrenal tumors
- Germ cell tumor[3][4]
- Congenital adrenal hyperplasia
- McCune–Albright syndrome
- Exogenous hormones
- Environmental exogenous hormones
- As treatment for another condition
Genetics
central precocious puberty
IT is caused by a mutation in the MKRN3 gene ( makorin ring finger protein 3 ) </ref>[5]
Idiopathic central precocious puberty disease
IT is caused by a mutation in the[6]
- KISS1\KISS1R (Kisspeptin)
- LIN28B (Lin-28 Homolog B)
- LIN28A (Lin-28 Homolog A)
eferences
- ↑ PMID 15349080 (PMID 15349080)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand - ↑ Tommiska J, Sørensen K, Aksglaede L, Koivu R, Puhakka L, Juul A; et al. (2011). "LIN28B, LIN28A, KISS1, and KISS1R in idiopathic central precocious puberty". BMC Res Notes. 4: 363. doi:10.1186/1756-0500-4-363. PMC 3184284. PMID 21939553.
- ↑ Template:Cite doi
- ↑ PMID 15339200 (PMID 15339200)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand) - ↑ Abreu AP, Dauber A, Macedo DB, Noel SD, Brito VN, Gill JC; et al. (2013). "Central precocious puberty caused by mutations in the imprinted gene MKRN3". N Engl J Med. 368 (26): 2467–75. doi:10.1056/NEJMoa1302160. PMC 3808195. PMID 23738509.
- ↑ Tommiska J, Sørensen K, Aksglaede L, Koivu R, Puhakka L, Juul A; et al. (2011). "LIN28B, LIN28A, KISS1, and KISS1R in idiopathic central precocious puberty". BMC Res Notes. 4: 363. doi:10.1186/1756-0500-4-363. PMC 3184284. PMID 21939553.