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Editor-In-Chief: C. Michael Gibson, M.S., M.D. ;Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. 
In anatomy, the papillary muscles of the heart serve to limit the movements of the mitral and tricuspid valves. These muscles contract to tighten the chordae tendineae, which in turn prevent inversion. This occurs in response to pressure gradients. Instead they brace the valves against the high pressure, preventing regurgitation of ventricular blood back into the atrial cavities.