Palmar plantar erythrodysesthesia causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mandana Chitsazan, M.D. [2]

Overview

Several different chemotherapeutic agents have been associated with palmar plantar erythrodysesthesia (PPE). Most frequently associated drugs include cytarabine, docetaxel, doxorubicin, liposomal-encapsulated doxorubicin, 5-fluorouracil, and capecitabine.

Causes

Chemotherapy drugs that can cause this syndrome include: [1]

Most Frequently Associated:

Less Frequently Associated:

Targeted Therapy Drugs Causing PPE:

References

  1. ↑ Baack BR, Burgdorf WH (1991). "Chemotherapy-induced acral erythema". J Am Acad Dermatol. 24 (3): 457–61. PMID 2061446.
  2. ↑ Baer MR, King LE, Wolff SN (1985). "Palmar-plantar erythrodysesthesia and cytarabine". Ann Intern Med. 102 (4): 556. doi:10.7326/0003-4819-102-4-556_1. PMID 3977204.
  3. ↑ Crawford JH, Eikelboom JW, McQuillan A (2002). "Recurrent palmar-plantar erythrodysaesthesia following high-dose cytarabine treatment for acute lymphoblastic leukemia". Eur J Haematol. 69 (5–6): 315–7. PMID 12460237.
  4. ↑ Zimmerman GC, Keeling JH, Burris HA, Cook G, Irvin R, Kuhn J; et al. (1995). "Acute cutaneous reactions to docetaxel, a new chemotherapeutic agent". Arch Dermatol. 131 (2): 202–6. PMID 7857119.
  5. ↑ Katoh M, Kadota M, Nishimura Y (2004). "A case of docetaxel-induced erythrodysesthesia". J Dermatol. 31 (5): 403–6. PMID 15187308.
  6. ↑ Amantea M, Newman MS, Sullivan TM, Forrest A, Working PK (1999). "Relationship of dose intensity to the induction of palmar-plantar erythrodysesthia by pegylated liposomal doxorubicin in dogs". Hum Exp Toxicol. 18 (1): 17–26. doi:10.1177/096032719901800103. PMID 10025364.
  7. ↑ Charrois GJ, Allen TM (2003). "Multiple injections of pegylated liposomal Doxorubicin: pharmacokinetics and therapeutic activity". J Pharmacol Exp Ther. 306 (3): 1058–67. doi:10.1124/jpet.103.053413. PMID 12808004.
  8. ↑ D'Agostino G, Ferrandina G, Ludovisi M, Testa A, Lorusso D, Gbaguidi N; et al. (2003). "Phase II study of liposomal doxorubicin and gemcitabine in the salvage treatment of ovarian cancer". Br J Cancer. 89 (7): 1180–4. doi:10.1038/sj.bjc.6601284. PMC 2394291. PMID 14520442.
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  10. ↑ Coukell AJ, Spencer CM (1997). "Polyethylene glycol-liposomal doxorubicin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the management of AIDS-related Kaposi's sarcoma". Drugs. 53 (3): 520–38. doi:10.2165/00003495-199753030-00011. PMID 9074848.
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  14. ↑ Vail DM, Chun R, Thamm DH, Garrett LD, Cooley AJ, Obradovich JE (1998). "Efficacy of pyridoxine to ameliorate the cutaneous toxicity associated with doxorubicin containing pegylated (Stealth) liposomes: a randomized, double-blind clinical trial using a canine model". Clin Cancer Res. 4 (6): 1567–71. PMID 9626479.
  15. ↑ Lokich JJ, Ahlgren JD, Gullo JJ, Philips JA, Fryer JG (1989). "A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: a Mid-Atlantic Oncology Program Study". J Clin Oncol. 7 (4): 425–32. doi:10.1200/JCO.1989.7.4.425. PMID 2926468.
  16. ↑ Fabian CJ, Molina R, Slavik M, Dahlberg S, Giri S, Stephens R (1990). "Pyridoxine therapy for palmar-plantar erythrodysesthesia associated with continuous 5-fluorouracil infusion". Invest New Drugs. 8 (1): 57–63. PMID 2345070.
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  18. ↑ Banfield GK, Crate ID, Griffiths CL (1995). "Long-term sequelae of Palmar-Plantar erythrodysaesthesia syndrome secondary to 5-fluorouracil therapy". J R Soc Med. 88 (6): 356P–357P. PMC 1295248. PMID 7629773.
  19. ↑ Bellmunt J, Navarro M, Hidalgo R, Solé LA (1988). "Palmar-plantar erythrodysesthesia syndrome associated with short-term continuous infusion (5 days) of 5-fluorouracil". Tumori. 74 (3): 329–31. PMID 3400123.
  20. ↑ Chiara S, Nobile MT, Barzacchi C, Sanguineti O, Vincenti M, Di Somma C; et al. (1997). "Hand-foot syndrome induced by high-dose, short-term, continuous 5-fluorouracil infusion". Eur J Cancer. 33 (6): 967–9. PMID 9291822.
  21. ↑ Comandone A, Bretti S, La Grotta G, Manzoni S, Bonardi G, Berardo R; et al. (1993). "Palmar-plantar erythrodysestasia syndrome associated with 5-fluorouracil treatment". Anticancer Res. 13 (5C): 1781–3. PMID 8267382.
  22. ↑ Curran CF, Luce JK (1989). "Fluorouracil and palmar-plantar erythrodysesthesia". Ann Intern Med. 111 (10): 858. doi:10.7326/0003-4819-111-10-858_1. PMID 2817635.
  23. ↑ Hoff PM, Ansari R, Batist G, Cox J, Kocha W, Kuperminc M; et al. (2001). "Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: results of a randomized phase III study". J Clin Oncol. 19 (8): 2282–92. doi:10.1200/JCO.2001.19.8.2282. PMID 11304782.
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  25. ↑ Leo S, Tatulli C, Taveri R, Campanella GA, Carrieri G, Colucci G (1994). "Dermatological toxicity from chemotherapy containing 5-fluorouracil". J Chemother. 6 (6): 423–6. PMID 7699432.
  26. ↑ Meta-Analysis Group In Cancer. Lévy E, Piedbois P, Buyse M, Pignon JP, Rougier P; et al. (1998). "Toxicity of fluorouracil in patients with advanced colorectal cancer: effect of administration schedule and prognostic factors". J Clin Oncol. 16 (11): 3537–41. doi:10.1200/JCO.1998.16.11.3537. PMID 9817272.
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  33. ↑ Blum JL, Jones SE, Buzdar AU, LoRusso PM, Kuter I, Vogel C; et al. (1999). "Multicenter phase II study of capecitabine in paclitaxel-refractory metastatic breast cancer". J Clin Oncol. 17 (2): 485–93. doi:10.1200/JCO.1999.17.2.485. PMID 10080589.
  34. ↑ Cassidy J, Twelves C, Van Cutsem E, Hoff P, Bajetta E, Boyer M; et al. (2002). "First-line oral capecitabine therapy in metastatic colorectal cancer: a favorable safety profile compared with intravenous 5-fluorouracil/leucovorin". Ann Oncol. 13 (4): 566–75. doi:10.1093/annonc/mdf089. PMID 12056707.
  35. ↑ Sternberg CN, Reichardt P, Holland M (2004). "Development of and clinical experience with capecitabine (Xeloda) in the treatment of solid tumours". Eur J Oncol Nurs. 8 Suppl 1: S4–15. doi:10.1016/j.ejon.2004.06.005. PMID 15341878.
  36. ↑ Van Cutsem E, Twelves C, Cassidy J, Allman D, Bajetta E, Boyer M; et al. (2001). "Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: results of a large phase III study". J Clin Oncol. 19 (21): 4097–106. doi:10.1200/JCO.2001.19.21.4097. PMID 11689577.
  37. ↑ Vakalis D, Ioannides D, Lazaridou E, Mattheou-Vakali G, Teknetzis A (1998). "Acral erythema induced by chemotherapy with cisplatin". Br J Dermatol. 139 (4): 750–1. PMID 9892931.
  38. ↑ Morgan M, Dodds A, Atkinson K, Szer J, Downs K, Biggs J (1991). "The toxicity of busulphan and cyclophosphamide as the preparative regimen for bone marrow transplantation". Br J Haematol. 77 (4): 529–34. PMID 2025579.
  39. ↑ Hui YF, Cortes JE (2000). "Palmar-plantar erythrodysesthesia syndrome associated with liposomal daunorubicin". Pharmacotherapy. 20 (10): 1221–3. PMID 11034047.
  40. ↑ Marigny K, Aubin F, Burgot G, Le Gall E, Gandemer V (2005). "Particular cutaneous side effects with etoposide-containing courses: is VP16 or etoposide phosphate responsible?". Cancer Chemother Pharmacol. 55 (3): 244–50. doi:10.1007/s00280-004-0858-2. PMID 15526203.
  41. ↑ Murphy CP, Harden EA, Herzig RH (1993). eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8490845 "Dose-related cutaneous toxicities with etoposide" Check |url= value (help). Cancer. 71 (10): 3153–5. doi:10.1002/1097-0142(19930515)71:10<3153::aid-cncr2820711042>3.0.co;2-#. PMID 8490845.
  42. ↑ Portal I, Cardenal F, Garcia-del-Muro X (1994). "Etoposide-related acral erythema". Cancer Chemother Pharmacol. 34 (2): 181. PMID 8194170.
  43. ↑ Schey SA, Cooper J, Summerhayes M (1992). "The "handfoot syndrome" occurring with chronic administration of etoposide". Eur J Haematol. 48 (2): 118–9. PMID 1547875.
  44. ↑ Neuss MN, Akwari OE, Stevenson DF, Goodwin BJ (1987). "Painful palmar and plantar erythema associated with hepatic artery infusion of 5-fluoro-2'deoxyuridine". J Natl Med Assoc. 79 (6): 669–71. PMC 2625536. PMID 2956430.
  45. ↑ Vassallo C, Passamonti F, Merante S, Ardigò M, Nolli G, Mangiacavalli S; et al. (2001). "Muco-cutaneous changes during long-term therapy with hydroxyurea in chronic myeloid leukaemia". Clin Exp Dermatol. 26 (2): 141–8. PMID 11298103.
  46. ↑ Cox GJ, Robertson DB (1986). "Toxic erythema of palms and soles associated with high-dose mercaptopurine chemotherapy". Arch Dermatol. 122 (12): 1413–4. PMID 2947543.
  47. ↑ Azurdia RM, Clark RE, Friedmann PS (1999). "Chemotherapy-induced acral erythema (CIAE) with bullous reaction". Clin Exp Dermatol. 24 (2): 64–6. PMID 10233654.
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  51. ↑ Morrell DS, Challgren E, Eapen M, Esterly NB (2002). "Bullous acral erythema secondary to high-dose methotrexate". J Pediatr Hematol Oncol. 24 (3): 240. PMID 11990316.
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  53. ↑ Zuehlke RL (1974). "Erythematous eruption of the palms and soles associated with mitotane therapy". Dermatologica. 148 (2): 90–2. PMID 4276191.
  54. ↑ Kupfer I, Balguerie X, Courville P, Chinet P, Joly P (2003). "Scleroderma-like cutaneous lesions induced by paclitaxel: a case study". J Am Acad Dermatol. 48 (2): 279–81. doi:10.1067/mjd.2003.30. PMID 12582404.
  55. ↑ Mavroudis D, Kouroussis Ch, Kakolyris S, Agelaki S, Kalbakis K, Androulakis N; et al. (2002). "Phase I study of paclitaxel (taxol) and pegylated liposomal doxorubicin (caelyx) administered every 2 weeks in patients with advanced solid tumors". Oncology. 62 (3): 216–22. doi:10.1159/000059568. PMID 12065868.
  56. ↑ Toppmeyer D, Seidman AD, Pollak M, Russell C, Tkaczuk K, Verma S; et al. (2002). "Safety and efficacy of the multidrug resistance inhibitor Incel (biricodar; VX-710) in combination with paclitaxel for advanced breast cancer refractory to paclitaxel". Clin Cancer Res. 8 (3): 670–8. PMID 11895894.
  57. ↑ Villalona-Calero MA, Blum JL, Jones SE, Diab S, Elledge R, Khoury P; et al. (2001). "A phase I and pharmacologic study of capecitabine and paclitaxel in breast cancer patients". Ann Oncol. 12 (5): 605–14. doi:10.1023/a:1011181010669. PMID 11432617.
  58. ↑ Bastida J, Díaz-Cascajo C, Borghi S (1997). "Chemotherapy-induced acral erythema due to Tegafur". Acta Derm Venereol. 77 (1): 72–3. doi:10.2340/00015555777273. PMID 9059686.
  59. ↑ Jucglà A, Sais G, Navarro M, Peyri J (1995). "Palmoplantar keratoderma secondary to chronic acral erythema due to tegafur". Arch Dermatol. 131 (3): 364–5. PMID 7887678.
  60. ↑ Rios-Buceta L, Buezo GF, Peñas PF, Dauden E, Fernandez-Herrera J, Garcia-Diez A (1997). "Palmar-plantar erythrodysaesthesia syndrome and other cutaneous side-effects after treatment with Tegafur". Acta Derm Venereol. 77 (1): 80–1. doi:10.2340/00015555778081. PMID 9059693.
  61. ↑ Hoff PM, Valero V, Ibrahim N, Willey J, Hortobagyi GN (1998). "Hand-foot syndrome following prolonged infusion of high doses of vinorelbine". Cancer. 82 (5): 965–9. doi:10.1002/(sici)1097-0142(19980301)82:5<965::aid-cncr23>3.0.co;2-y. PMID 9486588.
  62. ↑ Laack E, Mende T, Knuffmann C, Hossfeld DK (2001). "Hand-foot syndrome associated with short infusions of combination chemotherapy with gemcitabine and vinorelbine". Ann Oncol. 12 (12): 1761–3. doi:10.1023/a:1013575816870. PMID 11843256.
  63. ↑ Lorusso V, Crucitta E, Silvestris N, Guida M, Misino A, Latorre A; et al. (2003). "A phase I study of capecitabine in combination with vinorelbine in advanced breast cancer". Clin Breast Cancer. 4 (2): 138–41. PMID 12864942.
  64. ↑ Rosner F (1998). "Hand-foot syndrome following prolonged infusion of high doses of vinorelbine". Cancer. 83 (5): 1054–5. doi:10.1002/(sici)1097-0142(19980901)83:5<1054::aid-cncr40>3.0.co;2-3. PMID 9731914.
  65. ↑ Lacouture ME, Duvic M, Hauschild A, Prieto VG, Robert C, Schadendorf D; et al. (2013). "Analysis of dermatologic events in vemurafenib-treated patients with melanoma". Oncologist. 18 (3): 314–22. doi:10.1634/theoncologist.2012-0333. PMC 3607529. PMID 23457002.
  66. ↑ Powell BL, Lyerly ES, Motsinger CP, Cruz JM, Chorley HM, Hurd DD; et al. (1995). "Phase I study of continuous infusion 6-thioguanine in patients with acute leukemia". Leukemia. 9 (5): 770–3. PMID 7769838.
  67. ↑ Fischer A, Wu S, Ho AL, Lacouture ME (2013). "The risk of hand-foot skin reaction to axitinib, a novel VEGF inhibitor: a systematic review of literature and meta-analysis". Invest New Drugs. 31 (3): 787–97. doi:10.1007/s10637-013-9927-x. PMID 23345001.
  68. ↑ Belum VR, Serna-Tamayo C, Wu S, Lacouture ME (2016). "Incidence and risk of hand-foot skin reaction with cabozantinib, a novel multikinase inhibitor: a meta-analysis". Clin Exp Dermatol. 41 (1): 8–15. doi:10.1111/ced.12694. PMC 5066302. PMID 26009777.
  69. ↑ Kobayashi K, Kawakami K, Yokokawa T, Aoyama T, Suzuki K, Wakatsuki T; et al. (2019). "Association of Hand-Foot Skin Reaction with Regorafenib Efficacy in the Treatment of Metastatic Colorectal Cancer". Oncology. 96 (4): 200–206. doi:10.1159/000495989. PMID 30763946.
  70. ↑ 70.0 70.1 Velandia-Carrillo C, Wandurraga-Sánchez E, Gómez-Abreo D (2014). "Hand-foot syndrome associated with use of sorafenib in a patient with papillary thyroid cancer: a case report". BMC Endocr Disord. 14: 26. doi:10.1186/1472-6823-14-26. PMC 3994654. PMID 24641872.
  71. ↑ 71.0 71.1 Lee WJ, Lee JL, Chang SE, Lee MW, Kang YK, Choi JH; et al. (2009). "Cutaneous adverse effects in patients treated with the multitargeted kinase inhibitors sorafenib and sunitinib". Br J Dermatol. 161 (5): 1045–51. doi:10.1111/j.1365-2133.2009.09290.x. PMID 19558553.
  72. ↑ 72.0 72.1 Lacouture ME, Reilly LM, Gerami P, Guitart J (2008). "Hand foot skin reaction in cancer patients treated with the multikinase inhibitors sorafenib and sunitinib". Ann Oncol. 19 (11): 1955–61. doi:10.1093/annonc/mdn389. PMID 18550575.
  73. ↑ Sundriyal D, Kumar N (2015). "Pazopanib induced hand-foot syndrome". Oxf Med Case Reports. 2015 (2): 206–7. doi:10.1093/omcr/omv013. PMC 4370017. PMID 25988081.
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