Thioredoxin domain-containing protein 3 (TXNDC3), also known as spermatid-specific thioredoxin-2 (Sptrx-2), is a protein that in humans is encoded by the NME8gene (also known as the TXNDC3 gene) on chromosome 7.[1][2]
This gene encodes a protein with an N-terminalthioredoxin domain and three C-terminal nucleoside diphosphate kinase (NDK) domains, but the NDK domains are thought to be catalytically inactive. The sea urchin ortholog of this gene encodes a component of sperm outer dynein arms, and the protein is implicated in ciliary function.[1]
↑Sadek CM, Damdimopoulos AE, Pelto-Huikko M, Gustafsson JA, Spyrou G, Miranda-Vizuete A (Dec 2001). "Sptrx-2, a fusion protein composed of one thioredoxin and three tandemly repeated NDP-kinase domains is expressed in human testis germ cells". Genes to Cells. 6 (12): 1077–90. doi:10.1046/j.1365-2443.2001.00484.x. PMID11737268.
Padma P, Hozumi A, Ogawa K, Inaba K (Sep 2001). "Molecular cloning and characterization of a thioredoxin/nucleoside diphosphate kinase related dynein intermediate chain from the ascidian, Ciona intestinalis". Gene. 275 (1): 177–83. doi:10.1016/S0378-1119(01)00661-8. PMID11574167.
Zintzaras E, Kitsios GD, Ziogas DC, Rodopoulou P, Karachalios T (Apr 2010). "Field synopsis and synthesis of genetic association studies in osteoarthritis: the CUMAGAS-OSTEO information system". American Journal of Epidemiology. 171 (8): 851–8. doi:10.1093/aje/kwq016. PMID20237151.
Lacombe ML, Milon L, Munier A, Mehus JG, Lambeth DO (Jun 2000). "The human Nm23/nucleoside diphosphate kinases". Journal of Bioenergetics and Biomembranes. 32 (3): 247–58. doi:10.1023/A:1005584929050. PMID11768308.
