Merkel cell cancer surgery

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Merkel cell cancer Microchapters


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Differentiating Merkel Cell Cancer from other Diseases

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Natural History, Complications and Prognosis



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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]


The predominant therapy for merkel cell cancer is surgical resection.


  • The initial standard approach for patients with merkel cell cancer is wide excision.
  • According to:[1]
    • European Dermatology Forum (EDF)
    • European Association of Dermato-Oncology (EADO)
    • European Organization of Research and Treatment of Cancer (EORTC) the primary tumour should be excised a margin of at least 1 to 2 cm of healthy tissue surrounding it.
  • Overall survival rate in patients with merkel cell cancer increases dramatically by achieving negative margins during excision of the tumour.[2]
  • Regional lymph nodes are often resection because they may contain cancer cells.

Mohs micrographic surgery


  1. Lebbe C, Becker JC, Grob JJ, Malvehy J, Del Marmol V, Pehamberger H, Peris K, Saiag P, Middleton MR, Bastholt L, Testori A, Stratigos A, Garbe C (November 2015). "Diagnosis and treatment of Merkel Cell Carcinoma. European consensus-based interdisciplinary guideline". Eur. J. Cancer. 51 (16): 2396–403. doi:10.1016/j.ejca.2015.06.131. PMID 26257075.
  2. Tai PT, Yu E, Tonita J, Gilchrist J (October 2000). "Merkel cell carcinoma of the skin". J Cutan Med Surg. 4 (4): 186–95. doi:10.1177/120347540000400403. PMID 11231196.
  3. O'Connor WJ, Roenigk RK, Brodland DG (October 1997). "Merkel cell carcinoma. Comparison of Mohs micrographic surgery and wide excision in eighty-six patients". Dermatol Surg. 23 (10): 929–33. PMID 9357504.
  4. Boyer JD, Zitelli JA, Brodland DG, D'Angelo G (December 2002). "Local control of primary Merkel cell carcinoma: review of 45 cases treated with Mohs micrographic surgery with and without adjuvant radiation". J. Am. Acad. Dermatol. 47 (6): 885–92. doi:10.1067/mjd.2002.125083. PMID 12451374.

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