Lymphocytic interstitial pneumonia

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Lymphocytic interstitial pneumonia
DiseasesDB 31904

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Lymphocytic interstitial pneumonitis; lymphoid interstitial pneumonitis; LIP


Lymphocytic interstitial pneumonia is a syndrome secondary to autoimmune and other lymphoproliferative disorders. Symptoms include fever, cough, and shortness of breath. Lymphocytic interstitial pneumonia applies to a disorders associated with both, monoclonal or polyclonal gammopathy.[1]


Possible causes of lymphocytic interstitial pneumonia include

Drugs like



Physical Examination





Laboratory Findings


A lung biopsy may also be indicated.[4]


Patients presenting with no symptoms, and not affected by the syndrome may not require treatment. However, antibiotics are usually required for bacterial pulmonary infections. Bronchodilators may assist with breathing issues and resolution may occur with the use of Highly Active Anti-Retroviral Therapy. However, responses to different treatments are widely varied, and no single first line treatment represents the default treatment for lymphocytic interstitial pneumonia.[5]


  1. The Pathology of Idiopathic Interstitial Pneumonias Carol Farver, MD
  2. Teirstein AS, Rosen MJ. Lymphocytic interstitial pneumonia. Clin Chest Med 1988;9:467-471
  3. Pitt J. Lymphocytic interstitial pneumonia. Pediatr Clin N Am 1991;38:89-95.
  4. Strimlan CV, Rosenow EC, Weiland LH, Brown LR. Lymphocytic interstitial pneumonia. Review of 13 cases. Ann Intern Med 1978;88:616-621
  5. Teirstein AS, Rosen MJ. Lymphocytic interstitial pneumonia. Clin Chest Med 1988;9:467-471

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