Lung cancer causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kim-Son H. Nguyen M.D. Cafer Zorkun, M.D., Ph.D. [2] Dildar Hussain, MBBS [3]

Overview

The direct cause of lung cancer is DNA mutations that often result in either activation of proto-oncogenes (e.g. K-RAS) or the inactivation of tumors suppressor genes (e.g. TP53) or both. The risk of these genetic mutations may be increased following exposure to environmental insults.

Causes

  • To view a comprehensive list of risk factors that increase the risk of lung cancer, click here.

References

  1. American Cancer Society. Cancer Facts & Figures 2017. Atlanta: American Cancer Society; 2017.
  2. Karachaliou N, Mayo C, Costa C, Magrí I, Gimenez-Capitan A, Molina-Vila MA, Rosell R (2013). "KRAS mutations in lung cancer". Clin Lung Cancer. 14 (3): 205–14. doi:10.1016/j.cllc.2012.09.007. PMID 23122493.

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