Hepatitis D other diagnostic studies
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Hepatitis D |
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Treatment |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2] Jolanta Marszalek, M.D. [3]
Overview
The identification of the genotype of HDV helps to predict the potential severity of liver disease, as well as the response to treatment. Endoscopy may be useful in patients with advanced stage of the disease, who present with liver cirrhosis, to evaluate the presence of esophageal varices.[1][2][3]
Other Diagnostic Studies
Genotyping
The use of genotyping as a diagnostic test is gaining acceptance among different countries. The association of HDV genotype 1 with a higher degree of liver disease, and with a worst response to treatment with pegylated IFN, justifies the importance of this test.[1]
HDV genotyping is not indicated in North America and Europe as a diagnostic tool, not only because genotype 1 is the most common type in these regions, but also because the different genotypes have responded well to common antiviral treatments.[2]
Endoscopy
Patients with liver cirrhosis should be evaluated for the presence of esophageal varices.[2][3]
References
- ↑ 1.0 1.1 Su CW, Huang YH, Huo TI, Shih HH, Sheen IJ, Chen SW; et al. (2006). "Genotypes and viremia of hepatitis B and D viruses are associated with outcomes of chronic hepatitis D patients". Gastroenterology. 130 (6): 1625–35. doi:10.1053/j.gastro.2006.01.035. PMID 16697726.
- ↑ 2.0 2.1 2.2 Heidrich B, Manns MP, Wedemeyer H (2013). "Treatment options for hepatitis delta virus infection". Curr Infect Dis Rep. 15 (1): 31–8. doi:10.1007/s11908-012-0307-z. PMID 23242761.
- ↑ 3.0 3.1 Zachou K, Yurdaydin C, Drebber U, Dalekos GN, Erhardt A, Cakaloglu Y; et al. (2010). "Quantitative HBsAg and HDV-RNA levels in chronic delta hepatitis". Liver Int. 30 (3): 430–7. doi:10.1111/j.1478-3231.2009.02140.x. PMID 19840253.