Endometriosis laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aravind Kuchkuntla, M.B.B.S[2], Joseph Nasr, M.D.[3], Mohammed Abdelwahed M.D[4]
Overview
Laboratory findings associated with endometriosis include features of iron deficiency anemia and increased levels of cancer antigen-125 and interleukin 1. However, no diagnostic blood or molecular markers for endometriosis have been validated in clinical populations.[1]
Laboratory Findings
Currently, there are no validated blood-based diagnostic tests for endometriosis.[1]
Laboratory testing is not sufficient to establish the diagnosis and is primarily used to evaluate associated conditions or alternative diagnoses.
Laboratory findings associated with endometriosis include:
- Features of iron deficiency anemia may be present such as:
- Elevated levels of serum cancer antigen-125 may be present in patients with endometriosis[2]
- Elevated levels of serum cancer antigen-125 may be used to differentiate between endometriosis and other adnexal masses[3]
- Increased levels of interleukin 1, chemoattractant protein-1, and interferon gamma may be present in patients with endometriosis. These are useful markers to monitor disease activity and progression.[4]
- Research is ongoing to identify novel blood biomarkers for endometriosis detection and management; however, these biomarkers have not yet been validated for routine clinical use.[1]
References
- ↑ 1.0 1.1 1.2 Gibbons T, Rahmioglu N, Zondervan KT, Becker CM. Crimson clues: advancing endometriosis detection and management with novel blood biomarkers. Fertil Steril. 2024;121(2):145-163. doi:10.1016/j.fertnstert.2023.12.018
- ↑ Caroline C, Bashir T (2002). "Exceptionally high levels of CA125 due to endometriosis". J Obstet Gynaecol. 22 (3): 329–30. doi:10.1080/01443610252971320. PMID 12521524.
- ↑ Mol BW, Bayram N, Lijmer JG, Wiegerinck MA, Bongers MY, van der Veen F; et al. (1998). "The performance of CA-125 measurement in the detection of endometriosis: a meta-analysis". Fertil Steril. 70 (6): 1101–8. PMID 9848302.
- ↑ Ahn SH, Singh V, Tayade C (2017). "Biomarkers in endometriosis: challenges and opportunities". Fertil Steril. 107 (3): 523–532. doi:10.1016/j.fertnstert.2017.01.009. PMID 28189296.