Cystic fibrosis MRI

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]

Overview

MRI may be helpful in determining the cause of linear lung markings in cystic fibrosis. It is also helpful in differentiating mucous plugging and peribronchial thickening from normal pulmonary blood vessels. Because of MRI absence of ionising radiation and possibility for obtaining functional information, it is helpful for assessing lung disease in children who require repetitive follow up imaging for a long time. MRI studies of the pancreas have demonstrated different patterns of fatty infiltration, ductal changes, pancreatic cysts, calcifications and hypoechoic areas representing fibrosis.

MRI

• Lung MRI may be helpful in the diagnosis of cystic fibrosis. It demonstrates structural and perfusion abnormalities in children and young people with cystic fibrosis.
• MRI may be helpful in determining the cause of linear lung markings in cystic fibrosis. It is also helpful in differentiating mucous plugging and peribronchial thickening from normal pulmonary blood vessels.
• Because of MRI absence of ionising radiation and possibility for obtaining functional information, it is helpful for assessing lung disease in children who require repetitive follow up imaging for a long time.

• In cystic fibrosis the sensitivity of MRI in presenting pancreatic abnormality is 94%.
• MRI studies of the pancreas have demonstrated:
  • Different patterns of fatty infiltration:
    • Diffuse fatty replacement
    • Partial fatty replacement
    • Pancreatic atrophy
  • Ductal changes
  • Pancreatic cysts (ranging from small to severe pancreatic cystosis)
  • Calcifications
  • Hypoechoic areas representing fibrosis