Co-amoxiclav drug interactions

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Probenecid decreases the renal tubular secretion of amoxicillin. Concurrent use with Co-amoxiclav may result in increased and prolonged blood levels of amoxicillin. Coadministration of probenecid cannot be recommended.

Allopurinol and Ampicillin

The concurrent administration of allopurinol and ampicillin increases substantially the incidence of rashes in patients receiving both drugs as compared to patients receiving ampicillin alone. It is not known whether this potentiation of ampicillin rashes is due to allopurinol or the hyperuricemia present in these patients. There are no data with Co-amoxiclav and allopurinol administered concurrently.

Broad-Spectrum Antibiotics

In common with other broad-spectrum antibiotics, Co-amoxiclav may reduce the efficacy of oral contraceptives.

Complete List of Drug Interactions

Augmentin is a multi-ingredient drug consisting of:

Interactions with each of its ingredients have been shown below:

Amoxicillin Drug Interactions

Amoxicillin is known to interact with the following drugs:

Major Interactions

Moderate Interactions

Minor Interactions

Clavulanic Acid (Clavulanate) Drug Interactions

Moderate Interactions

Adapted from the FDA Package Insert.

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