Chronic renal failure future or investigational therapies

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Emerging Therapies

• Primary, secondary, and tertiary prevention of CKD is increasingly possible because of genetic diagnoses. 
• A recent study involving a small molecule Inaxaplin reverses the toxic gain-of-function effect of APOL1 high-risk variants, in patients with two APOL1 variants and biopsy-proven FSGS.
• A mouse model showed that gene transfer of Pkd1 trans gene lead to re expression of polycystic 1 protein thereby markedly delayed cyst development, retarded cyst progression, and postponed kidney failure in Pkd