Caplans syndrome diagnostic study of choice
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sharmi Biswas, M.B.B.S
Overview
Chest X ray and pulmonary function test are very helpful to diagnose Caplan Syndrome. Biopsy of the lung nodules are confirmatory test.
Diagnostic Study of Choice
Study of choice
Biopsy of the lung nodules is the golden diagnostic test for the diagnosis of Caplan Syndrome.but Caplan Syndrome can be initially diagnosed based on chest x ray and pulmonary function test.
Diagnostic Criteria
Caplan syndrome may be diagnosed at any time if one or more of the following criteria are met [1] [2]:
- Multiple, round, well defined nodules seen in Chest x ray which are usually 0.5-2 cm in diameter, cavitating resembling tuberculosis.CT guided thoracic punch biopsy of the lung nodules show typical features of rheumatoid nodules surrounded by palisade macrophages.
- Combination of obstructive and restrictive features in lung function test and decreased diffusing capacity of carbon monoxide.
- Serum study can show the presence of Rheumatoid factor, antinuclear antibodies or non organ specific antibodies.
References
- ↑ De Capitani, Eduardo Mello; Schweller, Marcelo; Silva, Cristiane Mendes da; Metze, Konradin; Cerqueira, Elza Maria Figueiras Pedreira de; Bértolo, Manoel Barros (2009). "Pneumoconiose reumatoide (síndrome de Caplan) com apresentação clássica". Jornal Brasileiro de Pneumologia. 35 (9): 942–946. doi:10.1590/S1806-37132009000900017. ISSN 1806-3713.
- ↑ Alaya, Raja; Zouche, Imen; Kaffel, Dhia; Riahi, Hend; Hamdi, Wafa; Kchir, Mohamed Montacer (2017). "Caplan's syndrome in an elderly-onset rheumatoid arthritis patient: About a new case". The Egyptian Rheumatologist. 39 (4): 255–258. doi:10.1016/j.ejr.2017.04.013. ISSN 1110-1164.