Bicuspid aortic stenosis laboratory tests
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Varun Kumar, M.B.B.S. [2]; Usama Talib, BSc, MD [3]
Overview
Laboratory tests such as lipid profile, BNP levels and blood studies help in assessing the progress and outcomes of bicuspid aortic stenosis.
Laboratory Tests
- As hypercholesterolemia is one of the risk factors that accelerates the stenotic process via calcification, serum cholesterol levels should be tested which could aid in recommending dietary modifications or medications.
- Total cholesterol and high-density lipoprotein (HDL) or fasting lipid panel should be measured in children over 3 years of age.
- Elevated low-density lipoprotein (LDL) may accelerate sclerosis of the bicuspid aortic valve.[1]
- Brain natriuretic peptide (BNP) may aid in assessing the cardiac function of patients with asymptomatic severe bicuspid aortic stenosis.[2]. Rising levels of BNP predicts the need for valve surgery in patients with asymptomatic severe aortic stenosis. It may also provide important prognostic information on postoperative outcomes.[3]
- Complete blood count with peripheral smear may reveal hemolytic anemia with schistocytes secondary to mechanical trauma to RBCs from calcified bicuspid valves.
References
- ↑ Chui MC, Newby DE, Panarelli M, Bloomfield P, Boon NA (2001). "Association between calcific aortic stenosis and hypercholesterolemia: is there a need for a randomized controlled trial of cholesterol-lowering therapy?". Clinical Cardiology. 24 (1): 52–5. PMID 11195607. Unknown parameter
|month=ignored (help);|access-date=requires|url=(help) - ↑ Bergler-Klein J (2009). "Natriuretic peptides in the management of aortic stenosis". Current Cardiology Reports. 11 (2): 85–93. PMID 19236823. Unknown parameter
|month=ignored (help);|access-date=requires|url=(help) - ↑ Bergler-Klein J, Klaar U, Heger M, Rosenhek R, Mundigler G, Gabriel H, Binder T, Pacher R, Maurer G, Baumgartner H (2004). "Natriuretic peptides predict symptom-free survival and postoperative outcome in severe aortic stenosis". Circulation. 109 (19): 2302–8. doi:10.1161/01.CIR.0000126825.50903.18. PMID 15117847. Retrieved 2012-04-11. Unknown parameter
|month=ignored (help)