Bazin disease overview

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Historical Perspective



Differentiating Bazin disease from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis


History and Symptoms

Physical Examination

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Bazin disease is a skin ulceration on the back of the calves. It was formerly thought to be a reaction to the tuberculum bacillus. It is very rare now.

Historical Perspective

Bazin disease is named for Pierre-Antoine-Ernest Bazin.[1][2]


Bazin disease is a type of panniculitis characterized histologically by the presence of granulomas, vasculitis, and necrosis.


Bazin disease was formerly thought to be a reaction to tuberculum bacillus, but it is now considered a panniculitis that is not associated with a single defined pathogen. [3]

Epidemiology and Demographics

Bazin disease is seen most commonly in adolescent and menopausal women.

Risk Factors

Bazin disease is initiated or exacerbated by cold weather.


History and Symptoms

50% of patients will have a past or present history of tuberculosis at extracutaneous site. Patients typically presents as one or more recurrent erythrocyanotic nodules or plaques on the calves.

Physical Examination

Patients typically presents as one or more recurrent erythrocyanotic nodules or plaques on the calves.


  1. Template:WhoNamedIt
  2. P. A. E. Bazin. Leçons théoriques et cliniques sur la scrofule, considérée en ellemême et dans ses rapports avec la syphilis, la dartre et l'arthritis. 2nd edition, Paris, 1861. Page 145 and 501.
  3. Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. p. 1265. ISBN 0-7216-0187-1.

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