Aspergillus niger

Jump to navigation Jump to search

Aspergillosis Microchapters


Patient Information


Historical Perspective




Differentiating Aspergillosis from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis


Diagnostic Criteria

History and Symptoms

Physical Examination

Laboratory Findings

Chest X Ray


Other Diagnostic Studies


Medical Therapy


Primary Prevention

Future or Investigational Therapies

Case Studies

Case #1

Aspergillus niger On the Web

Most recent articles

cited articles

Review articles

CME Programs

Powerpoint slides


American Roentgen Ray Society Images of Aspergillus niger

All Images
Echo & Ultrasound
CT Images

Ongoing Trials at Clinical

US National Guidelines Clearinghouse

NICE Guidance

FDA on Aspergillus niger

CDC on Aspergillus niger

Aspergillus niger in the news

Blogs on Aspergillus niger


Risk calculators and risk factors for Aspergillus niger

Aspergillus niger
Micrograph of A. niger grown on Sabouraud agar medium. 100x magnification.
Micrograph of A. niger grown on Sabouraud agar medium. 100x magnification.
Scientific classification
Domain: Eukaryota
Kingdom: Fungi
Phylum: Ascomycota
Subphylum: Pezizomycotina
Class: Eurotiomycetes
Order: Eurotiales
Family: Trichocomaceae
Genus: Aspergillus
Species: A. niger
Binomial name
Aspergillus niger
van Tieghem 1867

Aspergillus niger is a fungus and one of the most common species of the genus Aspergillus. It causes a disease called black mold on certain fruits and vegetables such as grapes, onions, and peanuts, and is a common contaminant of food. It is ubiquitous in soil and is commonly reported from indoor environments, where its black colonies can be confused with those of Stachybotrys (species of which have also been called "black mold").[1]

Some strains of A. niger have been reported to produce potent mycotoxins called ochratoxins,[2] but other sources disagree, claiming the latter report is based upon misidentification of the fungal species. Recent evidence suggests some true A. niger strains do produce ochratoxin A.[1][3]


A. niger is included in Aspergillus subgenus Circumdati, section Nigri. The section Nigri includes 15 related black-spored species that may be confused with A. niger, including A. tubingensis, A. foetidus, A. carbonarius, and A. awamori.[4][5] A number of morphologically similar species were recently described by Samson et al.[5]


Plant disease

A. niger causes black mold of onions. Infection of onion seedlings by A. niger can become systemic, manifesting only when conditions are conducive. A. niger causes a common postharvest disease of onions, in which the black conidia can be observed between the scales of the bulb. The fungus also causes disease in peanuts and in grapes. The spore comes to common trees such as maple.

Human and animal disease

A. niger is less likely to cause human disease than some other Aspergillus species, but if large amounts of spores are inhaled, a serious lung disease, aspergillosis can occur. Aspergillosis is particularly frequent among horticultural workers who inhale peat dust, which can be rich in Aspergillus spores. Less commonly, it has been found on the walls of ancient Egyptian tombs and can be inhaled when the area is disturbed. A. niger is one of the most common causes of otomycosis (fungal ear infections), which can cause pain, temporary hearing loss and, in severe cases, damage to the ear canal and tympanic membrane.

A. niger growing in potato dextrose agar

Industrial uses

A. niger is cultured for the industrial production of many substances. Various strains of A. niger are used in the industrial preparation of citric acid (E330) and gluconic acid (E574) and have been assessed as acceptable for daily intake by the World Health Organisation.

Many useful enzymes are produced using industrial fermentation of A. niger. For example, A. niger glucoamylase is used in the production of high fructose corn syrup, and pectinases are used in cider and wine clarification. α-galactosidase, an enzyme that breaks down certain complex sugars, is a component of Beano® and other medications which the manufacturers claim can decrease flatulence. Another use for A. niger within the biotechnology industry is in the production of magnetic isotope-containing variants of biological macromolecules for NMR analysis.

Other uses

In 2006 it was reported that a secreted RNase produced by A. niger called actibind has antiangiogenic and anticarcinogenic characteristics.

A. niger is also cultured for the extraction of the enzymes glucose oxidase (GO) and Alpha-galactosidase (AGS). Glucose oxidase is used in the design of glucose biosensors, due to its high affinity for β-D-glucose.[6] Alpha-galactosidase is produced by fermenting Aspergillus niger; it is used to hydrolyze alpha 1-6 bonds found in melibiose, raffinose, and stachyose. Reactions between flour and water will cause severe food discoloration, and if consumed by the human body raw, severe sickness can ensue. If used in food that is cooked to be consumed, it may cause vomiting and mild fevers. If you are alergic to mold, and you consume black mold in any way shape or form, seek immediate medical consulting immediately.


The genomes of two different A. niger strains have been fully sequenced.[7]


  1. 1.0 1.1 Samson RA, Houbraken J, Summerbell RC, Flannigan B, Miller JD (2001). Common and important species of fungi and actinomycetes in indoor environments. In: Microogranisms in Home and Indoor Work Environments. New York: Taylor & Francis. pp. pp. 287-292. ISBN.
  2. Abarca M, Bragulat M, Castellá G, Cabañes F (1994). "Ochratoxin A production by strains of Aspergillus niger var. niger". Appl Environ Microbiol. 60 (7): 2650–2. PMID 8074536.
  3. E. Schuster, N. Dunn-Coleman, J. Frisvad, P. van Dijck (2002). "On the safety of Aspergillus niger - a review". Applied Microbiology and Biotechnology. 59 (4–5): 426–435. doi:10.1007/s00253-002-1032-6.
  4. Klich MA (2002). Identification of common Aspergillus species. Utrecht, The Netherlands, Centraalbureau voor Schimmelcultures. ISBN 90-70351-46-3.
  5. 5.0 5.1 Samson, RA, Houbraken JAMP, Kuijpers AFA, Frank JM, Frisvad JC (2004). "New ochratoxin A or sclerotium producing species in Aspergillus section Nigri". Studies in Mycology. 50: pp. 45-6.
  6. Staiano, Maria, Paolo Bazzicalupo, Mose' Rossi, and Sabato D'Auria. “Glucose biosensors as models for the development of advanced protein-based biosensors.” Molecular BioSystems 1 (2005): 354-362.
  7. Pel H, de Winde J, Archer D; et al. (2007). "Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88". Nat Biotechnol. 25 (2): 221–31. PMID 17259976.

External links

da:Aspergillus niger de:Aspergillus niger