Aspergillosis other diagnostic studies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]; Yazan Daaboul, M.D.; Serge Korjian M.D.

Overview

Skin biopsy may be helpful in the diagnosis of cutaneous aspergillosis.[1][2]

Other Diagnostic Studies

Skin Biopsy

  • Skin biopsy is helpful in the diagnosis of cutaneous aspergillosis.
  • Histopathologic examination with hematoxylin and eosin will variably demonstrate Aspergillus hyphae.[2]
  • The Gomori methenamine silver stain, however, clearly detects hyphae, since the hyphal cell wall stains black, while the background tissue stains green.
  • Aspergillus hyphae should have acute-angle branching and frequent septations on histopathological examination.

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References

  1. Mengoli C, Cruciani M, Barnes RA, Loeffler J, Donnelly JP (2009). "Use of PCR for diagnosis of invasive aspergillosis: systematic review and meta-analysis". Lancet Infect Dis. 9 (2): 89–96. doi:10.1016/S1473-3099(09)70019-2. PMID 19179225.
  2. 2.0 2.1 van Burik JA, Colven R, Spach DH (1998). "Cutaneous aspergillosis". J Clin Microbiol. 36 (11): 3115–21. PMC 105285. PMID 9774549.
  3. 3.0 3.1 3.2 "Public Health Image Library (PHIL)".