Aspergillosis history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]; Yazan Daaboul, M.D.; Serge Korjian M.D.


Symptoms of aspergillosis are dependent on the clinical syndrome and extent of disease invasion.[1][2] Patients with allergic bronchopulmonary aspergillosis or sinusitis have symptoms typical of asthma and sinusitis, respectively. Symptoms of invasive pulmonary aspergillosis include spiking fever, pleuritic chest pain, productive cough, dyspnea, and hemoptysis. Symptoms of chronic pulmonary aspergillosis include chronic fever, weight loss, productive cough, and hemoptysis.


  • When evaluating a patient for aspergillosis, a detailed history of the presenting symptom (duration, onset, progression), other associated symptoms, and occupational history should be performed. Other specific areas of focus when obtaining the history are outlined below:[1][2]
  • The following algorithm demonstrates common clinical syndromes that develop following Aspergillus inhalation among different patient groups:

Inhalation of Aspergillus spores
Healthy host
Cavitary lung disease
Chronic lung disease or mildly immunocompromised host
Immunocompromised host
Either asthma, cystic fibrosis, or atopy
No sequelae
Chronic necrotizing aspergillosis
Invasive pulmonary aspergillosis
Allergic bronchopulmonary aspergillosis (ABPA)

Adapted from Kousha M, Tadi R, and Soubani AO. Pulmonary aspergillosis: a clinical review. Euro Respir Rev. 2011;20(121):156-74[2] / Soubani AO, Chandrasekar PH. The clinical spectrum of pulmonary aspergillosis. Chest. 2002;121(6):1988-99.[3]


  • The specific clinical presentation of aspergillosis is determined by the exact clinical subtype of the disease:[1][2]

Allergic Bronchopulmonary Aspergillosis (ABPA)

Allergic Aspergillus Sinusitis / Rhinosinusitis


  • Most patients with aspergilloma are asymptomatic
  • Mild haemoptysis (most common symptom)
  • Cough
  • Dyspnea
  • Fever (related to bacterial super-infection)

Chronic Pulmonary Aspergillosis

Invasive Pulmonary Aspergillosis

Cutaneous Aspergillosis


  1. 1.0 1.1 1.2 Aspergillosis. MAYO CLINIC (2015) Accessed on February, 8 2016
  2. 2.0 2.1 2.2 2.3 Kousha M, Tadi R, Soubani AO (2011). "Pulmonary aspergillosis: a clinical review". Eur Respir Rev. 20 (121): 156–74. doi:10.1183/09059180.00001011. PMID 21881144.
  3. Soubani AO, Chandrasekar PH (2002). "The clinical spectrum of pulmonary aspergillosis". Chest. 121 (6): 1988–99. PMID 12065367.