Asperger syndrome pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shakiba Hassanzadeh, MD[2]
Overview
The exact pathophysiology of Asperger Syndrome is unknown, however some neuroimaging and neuropsychological studies have reported some findings.[1][2]
Pathophysiology
Neuroimaging studies have shown structural and functional brain abnormalities in patients with Asperger (AS) such as:[1][2]
- There has been a report on developmental problems of neuronal migration in the cerebral cortex during pregnancy and fetal development in patients with AS which may result in problems in the connectivity of the brain cortex.[3]
- Smaller gray matter in the ventromedial aspect of the temporal lobe[4] and bilateral caudate and left thalamus [5].
- Greater white matter around the basal ganglia and left inferior parietal lobe, but lower white matter volume in the right corpus callosum.[6]
- Larger amygdala and hippocampal in patients with AS is associated to their difficulty with emotional reactivity[7]
- Smaller anterior cingulate cortex (ACC) in AS patients is associated with their difficulty with self monitoring of behavior.[7]
- Lesion in the white matter of the right middle temporal gyrus.[8]
- Lower fractional anisotropy (FA) is seen mostly bilaterally and in the white matter (internal capsule, frontal, temporal, parietal and occipital lobe, cingulum and corpus callosum).[9]
- Localized disconnection in cerebellar neural pathways may lead to abnormalities in adaptive social behavior.[10]
- Abnormal functional connectivity of medial temporal lobe structures (amygdala and parahippocampus gyrus) is associated with difficulty in social cognition in AS patients.[11]
- Abnormal dysactivation of the frontal lobe (during neuropsychological tests).[12][13][14][15]
- Abnormal activation in the temporal cortex during face discrimination.[16]
- Decreased activation of fusiform and extrastriate cortices during facial emotion processing.[17]
- Executive dysfunctions are associated with abnormality in neural connectivity of the brain cortex.[18]
- Neuroimaging patterns of AS patients were the same in static stimuli (photo of a face) and dynamic stimuli (real face).[19]
Some chemical markers associated with AS include:[1]
- Increase in N-acetyl aspartate/choline (NAA/Cho) level in the right anterior cingulate is associated with higher scores in obsessive compulsive scale in patients with AS.[20]
- Increased in the activity of the presynaptic dopamine system in the striatum and frontal cortex in patients with AS.[21]
- There is an association in cortical serotonin 5-HT2A receptor binding and social communication in patients with AS.[22]
- Administration of oxytocin may improve emotion recognition, affective speech comprehension, increase eye gaze, and social interaction in patients with AS.[23]
Neuropsychological abnormalities in AS are:[2]
- Difficulty in passing theory of mind tasks
- Executive dysfunction
- Tendency to interpret visual stimuli in parts rather than wholes (poor central coherence)
- There are studies that suggest in patients with AS there is a Verbal IQ (VIQ) > Poor Performance IQ (PIQ) profile which shows strength on verbal skills relative to visuospatial skills and non-verbal problem solving (nonverbal learning disability)[24]
Associated Conditions
Asperger Syndrome (AS) is associated with several conditions which include:
- Attention deficit hyperactivity disorder (ADHD) (most common in pediatric patients)[25]
- Depression (most common in adolescent and adult patients)[25][26]
- Bipolar disorder[25][26]
- Tourette syndrome[25]
- Obsessive compulsive disorder (OCD)[25][26]
- Tic disorder[25]
- Anxiety disorders[26]
- Schizophrenia[27]
- Non-verbal learning disability[28]
- Difficulty in falling asleep, sleepiness after awakening and during daytime and poor sleep quality[29]
- There have been case-reports of Asperger Syndrome (AS) associated with aminoaciduria,[30] ligamentous laxity[31] and recurrent hypersomnia[32].
References
- ↑ 1.0 1.1 1.2 Faridi F, Khosrowabadi R (2017). "Behavioral, Cognitive and Neural Markers of Asperger Syndrome". Basic Clin Neurosci. 8 (5): 349–359. doi:10.18869/nirp.bcn.8.5.349. PMC 5691167. PMID 29167722.
- ↑ 2.0 2.1 2.2 Woodbury-Smith MR, Volkmar FR (2009). "Asperger syndrome". Eur Child Adolesc Psychiatry. 18 (1): 2–11. doi:10.1007/s00787-008-0701-0. PMID 18563474.
- ↑ Berthier ML, Starkstein SE, Leiguarda R (1990). "Developmental cortical anomalies in Asperger's syndrome: neuroradiological findings in two patients". J Neuropsychiatry Clin Neurosci. 2 (2): 197–201. doi:10.1176/jnp.2.2.197. PMID 2136076.
- ↑ Kwon H, Ow AW, Pedatella KE, Lotspeich LJ, Reiss AL (2004). "Voxel-based morphometry elucidates structural neuroanatomy of high-functioning autism and Asperger syndrome". Dev Med Child Neurol. 46 (11): 760–4. doi:10.1017/s0012162204001306. PMID 15540637.
- ↑ McAlonan GM, Suckling J, Wong N, Cheung V, Lienenkaemper N, Cheung C; et al. (2008). "Distinct patterns of grey matter abnormality in high-functioning autism and Asperger's syndrome". J Child Psychol Psychiatry. 49 (12): 1287–95. doi:10.1111/j.1469-7610.2008.01933.x. PMID 18673405.
- ↑ McAlonan GM, Cheung C, Cheung V, Wong N, Suckling J, Chua SE (2009). "Differential effects on white-matter systems in high-functioning autism and Asperger's syndrome". Psychol Med. 39 (11): 1885–93. doi:10.1017/S0033291709005728. PMID 19356262.
- ↑ 7.0 7.1 Semrud-Clikeman M, Fine JG, Bledsoe J, Zhu DC (2013). "Magnetic resonance imaging volumetric findings in children with Asperger syndrome, nonverbal learning disability, or healthy controls". J Clin Exp Neuropsychol. 35 (5): 540–50. doi:10.1080/13803395.2013.795528. PMID 23672532.
- ↑ Volkmar FR, Klin A, Schultz RT, Rubin E, Bronen R (2000). "Asperger's disorder". Am J Psychiatry. 157 (2): 262–7. doi:10.1176/appi.ajp.157.2.262. PMID 10671397.
- ↑ Bloemen OJ, Deeley Q, Sundram F, Daly EM, Barker GJ, Jones DK; et al. (2010). "White matter integrity in Asperger syndrome: a preliminary diffusion tensor magnetic resonance imaging study in adults". Autism Res. 3 (5): 203–13. doi:10.1002/aur.146. PMID 20625995.
- ↑ Catani M, Jones DK, Daly E, Embiricos N, Deeley Q, Pugliese L; et al. (2008). "Altered cerebellar feedback projections in Asperger syndrome". Neuroimage. 41 (4): 1184–91. doi:10.1016/j.neuroimage.2008.03.041. PMID 18495494.
- ↑ Welchew DE, Ashwin C, Berkouk K, Salvador R, Suckling J, Baron-Cohen S; et al. (2005). "Functional disconnectivity of the medial temporal lobe in Asperger's syndrome". Biol Psychiatry. 57 (9): 991–8. doi:10.1016/j.biopsych.2005.01.028. PMID 15860339.
- ↑ Fletcher PC, Happé F, Frith U, Baker SC, Dolan RJ, Frackowiak RS; et al. (1995). "Other minds in the brain: a functional imaging study of "theory of mind" in story comprehension". Cognition. 57 (2): 109–28. doi:10.1016/0010-0277(95)00692-r. PMID 8556839.
- ↑ Happé F, Ehlers S, Fletcher P, Frith U, Johansson M, Gillberg C; et al. (1996). "'Theory of mind' in the brain. Evidence from a PET scan study of Asperger syndrome". Neuroreport. 8 (1): 197–201. doi:10.1097/00001756-199612200-00040. PMID 9051780.
- ↑ Mundy P (2003). "Annotation: the neural basis of social impairments in autism: the role of the dorsal medial-frontal cortex and anterior cingulate system". J Child Psychol Psychiatry. 44 (6): 793–809. doi:10.1111/1469-7610.00165. PMID 12959489.
- ↑ Ring HA, Baron-Cohen S, Wheelwright S, Williams SC, Brammer M, Andrew C; et al. (1999). "Cerebral correlates of preserved cognitive skills in autism: a functional MRI study of embedded figures task performance". Brain. 122 ( Pt 7): 1305–15. doi:10.1093/brain/122.7.1305. PMID 10388796.
- ↑ Schultz RT, Gauthier I, Klin A, Fulbright RK, Anderson AW, Volkmar F; et al. (2000). "Abnormal ventral temporal cortical activity during face discrimination among individuals with autism and Asperger syndrome". Arch Gen Psychiatry. 57 (4): 331–40. doi:10.1001/archpsyc.57.4.331. PMID 10768694.
- ↑ Deeley Q, Daly EM, Surguladze S, Page L, Toal F, Robertson D; et al. (2007). "An event related functional magnetic resonance imaging study of facial emotion processing in Asperger syndrome". Biol Psychiatry. 62 (3): 207–17. doi:10.1016/j.biopsych.2006.09.037. PMID 17400195.
- ↑ Han YM, Chan AS (2017). "Disordered cortical connectivity underlies the executive function deficits in children with autism spectrum disorders". Res Dev Disabil. 61: 19–31. doi:10.1016/j.ridd.2016.12.010. PMID 28042973.
- ↑ "The influence of static versus naturalistic stimuli on face processing in children with and without Asperger syndrome or high-functioning autism".
- ↑ Oner O, Devrimci-Ozguven H, Oktem F, Yagmurlu B, Baskak B, Munir KM (2007). "Proton MR spectroscopy: higher right anterior cingulate N-acetylaspartate/choline ratio in Asperger syndrome compared with healthy controls". AJNR Am J Neuroradiol. 28 (8): 1494–8. doi:10.3174/ajnr.A0625. PMC 3166641. PMID 17846198.
- ↑ Nieminen-von Wendt TS, Metsähonkala L, Kulomäki TA, Aalto S, Autti TH, Vanhala R; et al. (2004). "Increased presynaptic dopamine function in Asperger syndrome". Neuroreport. 15 (5): 757–60. doi:10.1097/00001756-200404090-00003. PMID 15073509.
- ↑ Murphy DG, Daly E, Schmitz N, Toal F, Murphy K, Curran S; et al. (2006). "Cortical serotonin 5-HT2A receptor binding and social communication in adults with Asperger's syndrome: an in vivo SPECT study". Am J Psychiatry. 163 (5): 934–6. doi:10.1176/ajp.2006.163.5.934. PMID 16648340.
- ↑ Domes G, Kumbier E, Heinrichs M, Herpertz SC (2014). "Oxytocin promotes facial emotion recognition and amygdala reactivity in adults with asperger syndrome". Neuropsychopharmacology. 39 (3): 698–706. doi:10.1038/npp.2013.254. PMC 3895247. PMID 24067301.
- ↑ Lincoln, Alan; Courchesne, Eric; Allen, Mark; Hanson, Ellen; Ene, Michaela (1998). "Neurobiology of Asperger Syndrome": 145–163. doi:10.1007/978-1-4615-5369-4_8.
- ↑ 25.0 25.1 25.2 25.3 25.4 25.5 Ghaziuddin M, Weidmer-Mikhail E, Ghaziuddin N (1998). "Comorbidity of Asperger syndrome: a preliminary report". J Intellect Disabil Res. 42 ( Pt 4): 279–83. doi:10.1111/j.1365-2788.1998.tb01647.x. PMID 9786442.
- ↑ 26.0 26.1 26.2 26.3 Lugnegård T, Hallerbäck MU, Gillberg C (2011). "Psychiatric comorbidity in young adults with a clinical diagnosis of Asperger syndrome". Res Dev Disabil. 32 (5): 1910–7. doi:10.1016/j.ridd.2011.03.025. PMID 21515028.
- ↑ Marinopoulou M, Lugnegård T, Hallerbäck MU, Gillberg C, Billstedt E (2016). "Asperger Syndrome and Schizophrenia: A Comparative Neuropsychological Study". J Autism Dev Disord. 46 (7): 2292–304. doi:10.1007/s10803-016-2758-9. PMID 26936160.
- ↑ Cederlund M, Gillberg C (2004). "One hundred males with Asperger syndrome: a clinical study of background and associated factors". Dev Med Child Neurol. 46 (10): 652–60. doi:10.1017/s0012162204001100. PMID 15473168.
- ↑ Tani P, Lindberg N, Joukamaa M, Nieminen-von Wendt T, von Wendt L, Appelberg B; et al. (2004). "Asperger syndrome, alexithymia and perception of sleep". Neuropsychobiology. 49 (2): 64–70. doi:10.1159/000076412. PMID 14981336.
- ↑ Miles SW, Capelle P (1987). "Asperger's syndrome and aminoaciduria: a case example". Br J Psychiatry. 150: 397–400. doi:10.1192/bjp.150.3.397. PMID 3664113.
- ↑ Tantam D, Evered C, Hersov L (1990). "Asperger's syndrome and ligamentous laxity". J Am Acad Child Adolesc Psychiatry. 29 (6): 892–6. doi:10.1097/00004583-199011000-00008. PMID 2273016.
- ↑ Berthier ML, Santamaria J, Encabo H, Tolosa ES (1992). "Recurrent hypersomnia in two adolescent males with Asperger's syndrome". J Am Acad Child Adolesc Psychiatry. 31 (4): 735–8. doi:10.1097/00004583-199207000-00023. PMID 1644738.