Amoebiasis differential diagnosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D.  Associate Editor(s)-in-Chief: Yazan Daaboul, M.D.; Serge Korjian M.D.
Amoebiasis must be differentiated from other causes of abdominal pain, bloating, acute or chronic diarrhea, and weight loss, such as other infectious causes of gastroenteritis, including bacterial, viral, fungal, and parasitic pathogens, in addition to non-infectious causes, including acute pancreatitis, appendicitis, bowel obstruction, diverticulitis, drug reaction, hyperthyroidism, inflammatory bowel disease, celiac disease, lactose intolerance, Whipple disease, tropical sprue, and lymphoma.
Differentiating Amoebiasis from other Diseases
- Amoebiasis must be differentiated from other causes of acute or chronic diarrhea, bloating, abdominal pain, and fever (less common).
- Differential diagnosis of amoebiasis includes the following:
Infectious Differential Diagnoses
- Bacterial infections (e.g. E. coli infection, shigellosis, salmonellosis, C. jejuni infection)
- Viral infections (e.g. norovirus, rotavirus, astrovirus, HIV)
- Fungal infections (e.g. Candida spp.)
- Parasites (Giardia, Cryptosporidium spp., Cyclospora)
Non-infectious Differential Diagnoses
The following are the non-infectious differential diagnoses of E. coli enteritis:
- Acute pancreatitis
- Adrenal insufficiency and Waterhouse-Friedrichsen syndrome
- Allergy (e.g. insect bite allergy or anaphylaxis)
- Bowel obstruction
- Celiac disease
- Drug reaction (e.g. antimicrobial agents, antihypertensive therapy, chemotherapy, anticonvulsants)
- Familial Mediterranean fever
- Gastrointestinal perforation
- Inflammatory bowel disease (Crohn's disease or ulcerative colitis)
- Ischemic colitis
- Lactose intolerance
- Mesenteric ischemia
- Necrotizing enterocolitis
- Ogilvie syndrome
- Poisoning and toxicity (e.g. carbon monoxide poisoning, organophosphate poisoning, digitoxin toxicity)
- Ruptured abdominal aortic aneurysm
- Spider bite
- Tropical sprue
- Urinary tract infection
- Whipple disease
To view a comprehensive list of abdominal pain differential diagnoses, click here.
To view a comprehensive list of diarrhea differential diagnoses, click here.
The table below summarizes the findings that differentiate inflammatory causes of chronic diarrhea
||Abdominal CT scan with oral and intravenous (IV) contrast||bowel rest, IV fluid resuscitation, and broad-spectrum antimicrobial therapy which covers anaerobic bacteria and gram-negative rods|
||Endoscopy||Induction of remission with mesalamine and corticosteroids followed by the administration of sulfasalazine and 6-Mercaptopurine depending on the severity of the disease.|
||cysts shed with the stool||detects ameba DNA in feces||Amebic dysentery
Luminal amebicides for E. histolytica in the colon:
For amebic liver abscess:
- ↑ Konvolinka CW (1994). "Acute diverticulitis under age forty". Am J Surg. 167 (6): 562–5. PMID 8209928.
- ↑ Silverberg MS, Satsangi J, Ahmad T, Arnott ID, Bernstein CN, Brant SR; et al. (2005). "Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology". Can J Gastroenterol. 19 Suppl A: 5A–36A. PMID 16151544.
- ↑ Satsangi J, Silverberg MS, Vermeire S, Colombel JF (2006). "The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications". Gut. 55 (6): 749–53. doi:10.1136/gut.2005.082909. PMC 1856208. PMID 16698746.
- ↑ 4.0 4.1 Haque R, Huston CD, Hughes M, Houpt E, Petri WA (2003). "Amebiasis". N Engl J Med. 348 (16): 1565–73. doi:10.1056/NEJMra022710. PMID 12700377.