Thrombosis causes: Difference between revisions
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This increases the risk of clot formation and form microthrombi, which further grow and propagate. | This increases the risk of clot formation and form microthrombi, which further grow and propagate. | ||
2) Injury to the vascular endothelium : Intrinsic or secondary to external trauma (eg, catheterization) can cause [[Tunica intima|intimal]] damage and stimulates clot formation. See [[Coagulation]]. | 2) Injury to the vascular endothelium: Intrinsic or secondary to external trauma (eg, catheterization) can cause [[Tunica intima|intimal]] damage and stimulates clot formation. See [[Coagulation]]. | ||
3) Alterations in the constitution of blood ([[hypercoagulability]]): It is the propensity to develop thrombosis due to an abnormality in the system of coagulation. | 3) Alterations in the constitution of blood ([[hypercoagulability]]): It is the propensity to develop thrombosis due to an abnormality in the system of coagulation. | ||
Revision as of 15:54, 27 February 2013
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Thrombosis Microchapters |
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Site of Thrombosis |
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Differentiating Thrombosis from other Diseases |
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Thrombosis causes On the Web |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editors-in-Chief: Ujjwal Rastogi, MBBS [2]
Causes
Rudolf Virchow noted several factors affecting the clot formation, which are as follows:
1) Alterations in blood flow (stasis): Blood flows throughout the circulatory system, without significantly stopping or slowing any where. In certain pathological conditions where the blood flow slows down or stops, it causes:
- Increase in platelet to endothelium contact
- Decrease the dilution of clotting factors
This increases the risk of clot formation and form microthrombi, which further grow and propagate.
2) Injury to the vascular endothelium: Intrinsic or secondary to external trauma (eg, catheterization) can cause intimal damage and stimulates clot formation. See Coagulation.
3) Alterations in the constitution of blood (hypercoagulability): It is the propensity to develop thrombosis due to an abnormality in the system of coagulation.
These three conditions are collectively known as Virchow's triad and lead to intravascular coagulation, forming a mass of red blood cells, leukocytes, and fibrin.
This video explains the process of thrombosis:
{{#ev:youtube|X_POCRsy7i4}}
Other Causes
High altitude,[1] has also been known to induce thrombosis. Occasionally, abnormalities in coagulation are to blame.
References
- ↑ Kuipers S, Cannegieter SC, Middeldorp S, Robyn L, Büller HR, Rosendaal FR (2007). "The absolute risk of venous thrombosis after air travel: a cohort study of 8,755 employees of international organisations". PLoS Med. 4 (9): e290. doi:10.1371/journal.pmed.0040290. PMC 1989755. PMID 17896862.
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