Thrombophlebitis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords: White Leg; phlebitis
Overview
Historical Perspective
- In 1913, Burnham AC discussed thrombophlebitis in postoperative patients.[1]
- Historically, the treatment of thrombophlebitis was purely surgical and consisted of removal of the thrombosed vein.[2]
Classification
Thrombophlebitis can be classified according to the cause into:[3]
| Type of Thrombophlebitis | Description |
|---|---|
| Sterile | Most common type of thrombophlebitis |
| Traumatic | Associated with the following conditions:
|
| Infective | Mostly due to prolonged IV cannulation |
| Migratory | Recurrent thrombophlebitis at various sites. Associated with an underlying malignancy, most commonly adenocarcinoma of the pancreas |
Thrombophlebitis may also be classified according to the site into:[4]
- Superficial thrombophlebitis of the lower limb: most common location and it involves the great and short saphenous veins
- Superficial thrombophlebitis of the arms
- Superficial thrombophlebitis of the breast: also known as Mondor's disease
- Superficial thrombophlebitis of the abdominal wall
Pathophysiology
Pathogenesis
Microscopic Pathology
Genetics
Associated Conditions
Thrombophlebitis may be associated with the following conditions:
- Coagulation abnormalities:[3][5]
- Thromboangiitis obliterans (Buerger's Disease)[6]
- Underlying malignancy, especially adenocarcinoma of the pancreas in the case of migratory thrombophlebitis[7][8]
Causes
Common Causes
- Deep vein thrombosis
- Drug side effects
- Intravenous infusion
- IV catheter infection
- Levamisole-induced vasculopathy
- Penicillin G potassium infusion
- Thromboangiitis obliterans
- Thrombophlebitis migrans
- Varicose veins
- Vein injury
Causes by Organ System
Causes in Alphabetical Order
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3Differentiating Thrombophlebitis from other Diseases
Epidemiology and Demographics
Risk Factors
Natural History, Complications and Prognosis
Screening
Diagnosis
History and Symptoms | Physical Examination | Laboratory Findings | Ultrasound | Other Imaging Findings | Other Diagnostic Studies
Treatment
Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies
Case Studies
- ↑ Burnham AC (1913). "II. Postoperative Thrombophlebitis". Ann. Surg. 57 (2): 151–62. PMC 1407408. PMID 17862964.
- ↑ Homans J (1928). "THROMBOPHLEBITIS OF THE LOWER EXTREMITIES". Ann. Surg. 87 (5): 641–51. PMC 1398549. PMID 17865873.
- ↑ 3.0 3.1 Nasr H, Scriven JM (2015). "Superficial thrombophlebitis (superficial venous thrombosis)". BMJ. 350: h2039. PMID 26099257.
- ↑ Scott G, Mahdi AJ, Alikhan R (2015). "Superficial vein thrombosis: a current approach to management". Br. J. Haematol. 168 (5): 639–45. doi:10.1111/bjh.13255. PMID 25521017.
- ↑ Martinelli I, Cattaneo M, Taioli E, De Stefano V, Chiusolo P, Mannucci PM (1999). "Genetic risk factors for superficial vein thrombosis". Thromb. Haemost. 82 (4): 1215–7. PMID 10544900.
- ↑ Olin JW (2000). "Thromboangiitis obliterans (Buerger's disease)". N. Engl. J. Med. 343 (12): 864–9. doi:10.1056/NEJM200009213431207. PMID 10995867.
- ↑ Diaconu C, Mateescu D, Bălăceanu A, Marcu M, Jianu V, Stănică A (2010). "Pancreatic cancer presenting with paraneoplastic thrombophlebitis--case report". J Med Life. 3 (1): 96–9. PMC 3019029. PMID 20302205.
- ↑ Varki A (2007). "Trousseau's syndrome: multiple definitions and multiple mechanisms". Blood. 110 (6): 1723–9. doi:10.1182/blood-2006-10-053736. PMC 1976377. PMID 17496204.