TEC (gene): Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Tyrosine-protein kinase Tec''' is an [[enzyme]] that in humans is encoded by the ''TEC'' [[gene]].<ref name="pmid7934162">{{cite journal | vauthors = Sato K, Mano H, Ariyama T, Inazawa J, Yazaki Y, Hirai H | title = Molecular cloning and analysis of the human Tec protein-tyrosine kinase | journal = Leukemia | volume = 8 | issue = 10 | pages = 1663–72 | date = Oct 1994 | pmid = 7934162 | pmc = | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TEC tec protein tyrosine kinase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7006| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_TEC_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1gl5.
| PDB = {{PDB2|1gl5}}
| Name = Tec protein tyrosine kinase
| HGNCid = 11719
| Symbol = TEC
| AltSymbols =; MGC126760; MGC126762; PSCTK4
| OMIM = 600583
| ECnumber = 
| Homologene = 1302
| MGIid = 98662
| GeneAtlas_image1 = PBB_GE_TEC_206301_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004715 |text = non-membrane spanning protein tyrosine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007243 |text = protein kinase cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7006
    | Hs_Ensembl = ENSG00000135605
    | Hs_RefseqProtein = NP_003206
    | Hs_RefseqmRNA = NM_003215
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 47832557
    | Hs_GenLoc_end = 47966638
    | Hs_Uniprot = P42680
    | Mm_EntrezGene = 21682
    | Mm_Ensembl = ENSMUSG00000029217
    | Mm_RefseqmRNA = NM_013689
    | Mm_RefseqProtein = NP_038717
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 73034869
    | Mm_GenLoc_end = 73147618
    | Mm_Uniprot = Q3U436
  }}
}}
'''Tec protein tyrosine kinase''', also known as '''TEC''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TEC tec protein tyrosine kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7006| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein-coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome.<ref name="entrez">{{cite web | title = Entrez Gene: TEC tec protein tyrosine kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7006| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
TEC (gene) has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[ARHGEF12]],<ref name = pmid12515866/>
* [[CD117]],<ref name = pmid11071635>{{cite journal | vauthors = van Dijk TB, van Den Akker E, Amelsvoort MP, Mano H, Löwenberg B, von Lindern M | title = Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells | journal = Blood | volume = 96 | issue = 10 | pages = 3406–13 | date = Nov 2000 | pmid = 11071635 | doi =  }}</ref><ref name = pmid7526158>{{cite journal | vauthors = Tang B, Mano H, Yi T, Ihle JN | title = Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding | journal = Molecular and Cellular Biology | volume = 14 | issue = 12 | pages = 8432–7 | date = Dec 1994 | pmid = 7526158 | pmc = 359382 | doi =  }}</ref>
* [[DOK1]],<ref name = pmid11071635/><ref name = pmid11825908>{{cite journal | vauthors = Liang X, Wisniewski D, Strife A, Clarkson B, Resh MD | title = Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling | journal = The Journal of Biological Chemistry | volume = 277 | issue = 16 | pages = 13732–8 | date = Apr 2002 | pmid = 11825908 | doi = 10.1074/jbc.M200277200 }}</ref>
* [[GNA12]],<ref name = pmid12515866>{{cite journal | vauthors = Suzuki N, Nakamura S, Mano H, Kozasa T | title = Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 2 | pages = 733–8 | date = Jan 2003 | pmid = 12515866 | pmc = 141065 | doi = 10.1073/pnas.0234057100 }}</ref>
* [[Janus kinase 2]],<ref name = pmid9178903>{{cite journal | vauthors = Takahashi-Tezuka M, Hibi M, Fujitani Y, Fukada T, Yamaguchi T, Hirano T | title = Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK | journal = Oncogene | volume = 14 | issue = 19 | pages = 2273–82 | date = May 1997 | pmid = 9178903 | doi = 10.1038/sj.onc.1201071 }}</ref><ref name = pmid9473212>{{cite journal | vauthors = Yamashita Y, Watanabe S, Miyazato A, ((Ohya Ki)), Ikeda U, Shimada K, Komatsu N, Hatake K, Miura Y, Ozawa K, Mano H | title = Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription | journal = Blood | volume = 91 | issue = 5 | pages = 1496–507 | date = Mar 1998 | pmid = 9473212 | doi =  }}</ref>  and
* [[Suppressor of cytokine signaling 1]].<ref name = pmid9341160>{{cite journal | vauthors = ((Ohya Ki)), Kajigaya S, Yamashita Y, Miyazato A, Hatake K, Miura Y, Ikeda U, Shimada K, Ozawa K, Mano H | title = SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase | journal = The Journal of Biological Chemistry | volume = 272 | issue = 43 | pages = 27178–82 | date = Oct 1997 | pmid = 9341160 | doi =  10.1074/jbc.272.43.27178}}</ref>
{{Div col end}}
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Mano H | title = Tec family of protein-tyrosine kinases: an overview of their structure and function | journal = Cytokine & Growth Factor Reviews | volume = 10 | issue = 3-4 | pages = 267–80 | year = 2000 | pmid = 10647781 | doi = 10.1016/S1359-6101(99)00019-2 }}
| citations =
* {{cite journal | vauthors = Yang WC, Collette Y, Nunès JA, Olive D | title = Tec kinases: a family with multiple roles in immunity | journal = Immunity | volume = 12 | issue = 4 | pages = 373–82 | date = Apr 2000 | pmid = 10795735 | doi = 10.1016/S1074-7613(00)80189-2 }}
*{{cite journal | author=Mano H |title=Tec family of protein-tyrosine kinases: an overview of their structure and function. |journal=Cytokine Growth Factor Rev. |volume=10 |issue= 3-4 |pages= 267-80 |year= 2000 |pmid= 10647781 |doi= }}
* {{cite journal | vauthors = Mano H, Ishikawa F, Nishida J, Hirai H, Takaku F | title = A novel protein-tyrosine kinase, tec, is preferentially expressed in liver | journal = Oncogene | volume = 5 | issue = 12 | pages = 1781–6 | date = Dec 1990 | pmid = 2284097 | doi =  }}
*{{cite journal | author=Yang WC, Collette Y, Nunès JA, Olive D |title=Tec kinases: a family with multiple roles in immunity. |journal=Immunity |volume=12 |issue= 4 |pages= 373-82 |year= 2000 |pmid= 10795735 |doi= }}
* {{cite journal | vauthors = Tang B, Mano H, Yi T, Ihle JN | title = Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding | journal = Molecular and Cellular Biology | volume = 14 | issue = 12 | pages = 8432–7 | date = Dec 1994 | pmid = 7526158 | pmc = 359382 | doi =  }}
*{{cite journal | author=Mano H, Ishikawa F, Nishida J, ''et al.'' |title=A novel protein-tyrosine kinase, tec, is preferentially expressed in liver. |journal=Oncogene |volume=5 |issue= 12 |pages= 1781-6 |year= 1991 |pmid= 2284097 |doi=  }}
* {{cite journal | vauthors = Machide M, Mano H, Todokoro K | title = Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain | journal = Oncogene | volume = 11 | issue = 4 | pages = 619–25 | date = Aug 1995 | pmid = 7651724 | doi =  }}
*{{cite journal | author=Tang B, Mano H, Yi T, Ihle JN |title=Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding. |journal=Mol. Cell. Biol. |volume=14 |issue= 12 |pages= 8432-7 |year= 1994 |pmid= 7526158 |doi=  }}
* {{cite journal | vauthors = Mano H, Yamashita Y, Miyazato A, Miura Y, Ozawa K | title = Tec protein-tyrosine kinase is an effector molecule of Lyn protein-tyrosine kinase | journal = FASEB Journal | volume = 10 | issue = 5 | pages = 637–42 | date = Apr 1996 | pmid = 8621063 | doi =  }}
*{{cite journal | author=Machide M, Mano H, Todokoro K |title=Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain. |journal=Oncogene |volume=11 |issue= 4 |pages= 619-25 |year= 1995 |pmid= 7651724 |doi=  }}
* {{cite journal | vauthors = Rawlings DJ, Scharenberg AM, Park H, Wahl MI, Lin S, Kato RM, Fluckiger AC, Witte ON, Kinet JP | title = Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases | journal = Science | volume = 271 | issue = 5250 | pages = 822–5 | date = Feb 1996 | pmid = 8629002 | doi = 10.1126/science.271.5250.822 }}
*{{cite journal | author=Sato K, Mano H, Ariyama T, ''et al.'' |title=Molecular cloning and analysis of the human Tec protein-tyrosine kinase. |journal=Leukemia |volume=8 |issue= 10 |pages= 1663-72 |year= 1994 |pmid= 7934162 |doi=  }}
* {{cite journal | vauthors = Park H, Wahl MI, Afar DE, Turck CW, Rawlings DJ, Tam C, Scharenberg AM, Kinet JP, Witte ON | title = Regulation of Btk function by a major autophosphorylation site within the SH3 domain | journal = Immunity | volume = 4 | issue = 5 | pages = 515–25 | date = May 1996 | pmid = 8630736 | doi = 10.1016/S1074-7613(00)80417-3 }}
*{{cite journal  | author=Mano H, Yamashita Y, Miyazato A, ''et al.'' |title=Tec protein-tyrosine kinase is an effector molecule of Lyn protein-tyrosine kinase. |journal=FASEB J. |volume=10 |issue= 5 |pages= 637-42 |year= 1996 |pmid= 8621063 |doi=  }}
* {{cite journal | vauthors = Ohta Y, Haire RN, Amemiya CT, Litman RT, Träger T, Riess O, Litman GW | title = Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene | journal = Oncogene | volume = 12 | issue = 4 | pages = 937–42 | date = Feb 1996 | pmid = 8632917 | doi =  }}
*{{cite journal | author=Rawlings DJ, Scharenberg AM, Park H, ''et al.'' |title=Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases. |journal=Science |volume=271 |issue= 5250 |pages= 822-5 |year= 1996 |pmid= 8629002 |doi= }}
* {{cite journal | vauthors = Cory GO, MacCarthy-Morrogh L, Banin S, Gout I, Brickell PM, Levinsky RJ, Kinnon C, Lovering RC | title = Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways | journal = Journal of Immunology | volume = 157 | issue = 9 | pages = 3791–5 | date = Nov 1996 | pmid = 8892607 | doi =  }}
*{{cite journal | author=Park H, Wahl MI, Afar DE, ''et al.'' |title=Regulation of Btk function by a major autophosphorylation site within the SH3 domain. |journal=Immunity |volume=4 |issue= 5 |pages= 515-25 |year= 1996 |pmid= 8630736 |doi= }}
* {{cite journal | vauthors = Takahashi-Tezuka M, Hibi M, Fujitani Y, Fukada T, Yamaguchi T, Hirano T | title = Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK | journal = Oncogene | volume = 14 | issue = 19 | pages = 2273–82 | date = May 1997 | pmid = 9178903 | doi = 10.1038/sj.onc.1201071 }}
*{{cite journal | author=Ohta Y, Haire RN, Amemiya CT, ''et al.'' |title=Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene. |journal=Oncogene |volume=12 |issue= 4 |pages= 937-42 |year= 1996 |pmid= 8632917 |doi=  }}
* {{cite journal | vauthors = Laffargue M, Monnereau L, Tuech J, Ragab A, Ragab-Thomas J, Payrastre B, Raynal P, Chap H | title = Integrin-dependent tyrosine phoshorylation and cytoskeletal translocation of Tec in thrombin-activated platelets | journal = Biochemical and Biophysical Research Communications | volume = 238 | issue = 1 | pages = 247–51 | date = Sep 1997 | pmid = 9299487 | doi = 10.1006/bbrc.1997.7269 }}
*{{cite journal | author=Cory GO, MacCarthy-Morrogh L, Banin S, ''et al.'' |title=Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways. |journal=J. Immunol. |volume=157 |issue= 9 |pages= 3791-5 |year= 1996 |pmid= 8892607 |doi=  }}
* {{cite journal | vauthors = Kitanaka A, Mano H, Conley ME, Campana D | title = Expression and activation of the nonreceptor tyrosine kinase Tec in human B cells | journal = Blood | volume = 91 | issue = 3 | pages = 940–8 | date = Feb 1998 | pmid = 9446655 | doi =  }}
*{{cite journal | author=Takahashi-Tezuka M, Hibi M, Fujitani Y, ''et al.'' |title=Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK. |journal=Oncogene |volume=14 |issue= 19 |pages= 2273-82 |year= 1997 |pmid= 9178903 |doi= 10.1038/sj.onc.1201071 }}
* {{cite journal | vauthors = Yang WC, Ghiotto M, Barbarat B, Olive D | title = The role of Tec protein-tyrosine kinase in T cell signaling | journal = The Journal of Biological Chemistry | volume = 274 | issue = 2 | pages = 607–17 | date = Jan 1999 | pmid = 9872994 | doi = 10.1074/jbc.274.2.607 }}
*{{cite journal | author=Laffargue M, Monnereau L, Tuech J, ''et al.'' |title=Integrin-dependent tyrosine phoshorylation and cytoskeletal translocation of Tec in thrombin-activated platelets. |journal=Biochem. Biophys. Res. Commun. |volume=238 |issue= 1 |pages= 247-51 |year= 1997 |pmid= 9299487 |doi= 10.1006/bbrc.1997.7269 }}
* {{cite journal | vauthors = Yang WC, Olive D | title = Tec kinase is involved in transcriptional regulation of IL-2 and IL-4 in the CD28 pathway | journal = European Journal of Immunology | volume = 29 | issue = 6 | pages = 1842–9 | date = Jun 1999 | pmid = 10382746 | doi = 10.1002/(SICI)1521-4141(199906)29:06<1842::AID-IMMU1842>3.0.CO;2-D }}
*{{cite journal | author=Ohya K, Kajigaya S, Yamashita Y, ''et al.'' |title=SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase. |journal=J. Biol. Chem. |volume=272 |issue= 43 |pages= 27178-82 |year= 1997 |pmid= 9341160 |doi=  }}
* {{cite journal | vauthors = Ohya K, Kajigaya S, Kitanaka A, Yoshida K, Miyazato A, Yamashita Y, Yamanaka T, Ikeda U, Shimada K, Ozawa K, Mano H | title = Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 21 | pages = 11976–81 | date = Oct 1999 | pmid = 10518561 | pmc = 18397 | doi = 10.1073/pnas.96.21.11976 }}
*{{cite journal  | author=Kitanaka A, Mano H, Conley ME, Campana D |title=Expression and activation of the nonreceptor tyrosine kinase Tec in human B cells. |journal=Blood |volume=91 |issue= 3 |pages= 940-8 |year= 1998 |pmid= 9446655 |doi=  }}
*{{cite journal | author=Yamashita Y, Watanabe S, Miyazato A, ''et al.'' |title=Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription. |journal=Blood |volume=91 |issue= 5 |pages= 1496-507 |year= 1998 |pmid= 9473212 |doi=  }}
*{{cite journal  | author=Yang WC, Ghiotto M, Barbarat B, Olive D |title=The role of Tec protein-tyrosine kinase in T cell signaling. |journal=J. Biol. Chem. |volume=274 |issue= 2 |pages= 607-17 |year= 1999 |pmid= 9872994 |doi= }}
*{{cite journal | author=Yang WC, Olive D |title=Tec kinase is involved in transcriptional regulation of IL-2 and IL-4 in the CD28 pathway. |journal=Eur. J. Immunol. |volume=29 |issue= 6 |pages= 1842-9 |year= 1999 |pmid= 10382746 |doi= }}
*{{cite journal | author=Ohya K, Kajigaya S, Kitanaka A, ''et al.'' |title=Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 21 |pages= 11976-81 |year= 1999 |pmid= 10518561 |doi= }}
}}
{{refend}}
{{refend}}


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[[Category:Tyrosine kinases]]

Latest revision as of 11:44, 15 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
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View/Edit Human

Tyrosine-protein kinase Tec is an enzyme that in humans is encoded by the TEC gene.[1][2]

Function

The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein-coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome.[2]

Interactions

TEC (gene) has been shown to interact with:

References

  1. ↑ Sato K, Mano H, Ariyama T, Inazawa J, Yazaki Y, Hirai H (Oct 1994). "Molecular cloning and analysis of the human Tec protein-tyrosine kinase". Leukemia. 8 (10): 1663–72. PMID 7934162.
  2. ↑ 2.0 2.1 "Entrez Gene: TEC tec protein tyrosine kinase".
  3. ↑ 3.0 3.1 Suzuki N, Nakamura S, Mano H, Kozasa T (Jan 2003). "Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF". Proceedings of the National Academy of Sciences of the United States of America. 100 (2): 733–8. doi:10.1073/pnas.0234057100. PMC 141065. PMID 12515866.
  4. ↑ 4.0 4.1 van Dijk TB, van Den Akker E, Amelsvoort MP, Mano H, Löwenberg B, von Lindern M (Nov 2000). "Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells". Blood. 96 (10): 3406–13. PMID 11071635.
  5. ↑ Tang B, Mano H, Yi T, Ihle JN (Dec 1994). "Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding". Molecular and Cellular Biology. 14 (12): 8432–7. PMC 359382. PMID 7526158.
  6. ↑ Liang X, Wisniewski D, Strife A, Clarkson B, Resh MD (Apr 2002). "Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling". The Journal of Biological Chemistry. 277 (16): 13732–8. doi:10.1074/jbc.M200277200. PMID 11825908.
  7. ↑ Takahashi-Tezuka M, Hibi M, Fujitani Y, Fukada T, Yamaguchi T, Hirano T (May 1997). "Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK". Oncogene. 14 (19): 2273–82. doi:10.1038/sj.onc.1201071. PMID 9178903.
  8. ↑ Yamashita Y, Watanabe S, Miyazato A, Ohya Ki, Ikeda U, Shimada K, Komatsu N, Hatake K, Miura Y, Ozawa K, Mano H (Mar 1998). "Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription". Blood. 91 (5): 1496–507. PMID 9473212.
  9. ↑ Ohya Ki, Kajigaya S, Yamashita Y, Miyazato A, Hatake K, Miura Y, Ikeda U, Shimada K, Ozawa K, Mano H (Oct 1997). "SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase". The Journal of Biological Chemistry. 272 (43): 27178–82. doi:10.1074/jbc.272.43.27178. PMID 9341160.

Further reading

  • Mano H (2000). "Tec family of protein-tyrosine kinases: an overview of their structure and function". Cytokine & Growth Factor Reviews. 10 (3–4): 267–80. doi:10.1016/S1359-6101(99)00019-2. PMID 10647781.
  • Yang WC, Collette Y, Nunès JA, Olive D (Apr 2000). "Tec kinases: a family with multiple roles in immunity". Immunity. 12 (4): 373–82. doi:10.1016/S1074-7613(00)80189-2. PMID 10795735.
  • Mano H, Ishikawa F, Nishida J, Hirai H, Takaku F (Dec 1990). "A novel protein-tyrosine kinase, tec, is preferentially expressed in liver". Oncogene. 5 (12): 1781–6. PMID 2284097.
  • Tang B, Mano H, Yi T, Ihle JN (Dec 1994). "Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding". Molecular and Cellular Biology. 14 (12): 8432–7. PMC 359382. PMID 7526158.
  • Machide M, Mano H, Todokoro K (Aug 1995). "Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain". Oncogene. 11 (4): 619–25. PMID 7651724.
  • Mano H, Yamashita Y, Miyazato A, Miura Y, Ozawa K (Apr 1996). "Tec protein-tyrosine kinase is an effector molecule of Lyn protein-tyrosine kinase". FASEB Journal. 10 (5): 637–42. PMID 8621063.
  • Rawlings DJ, Scharenberg AM, Park H, Wahl MI, Lin S, Kato RM, Fluckiger AC, Witte ON, Kinet JP (Feb 1996). "Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases". Science. 271 (5250): 822–5. doi:10.1126/science.271.5250.822. PMID 8629002.
  • Park H, Wahl MI, Afar DE, Turck CW, Rawlings DJ, Tam C, Scharenberg AM, Kinet JP, Witte ON (May 1996). "Regulation of Btk function by a major autophosphorylation site within the SH3 domain". Immunity. 4 (5): 515–25. doi:10.1016/S1074-7613(00)80417-3. PMID 8630736.
  • Ohta Y, Haire RN, Amemiya CT, Litman RT, Träger T, Riess O, Litman GW (Feb 1996). "Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene". Oncogene. 12 (4): 937–42. PMID 8632917.
  • Cory GO, MacCarthy-Morrogh L, Banin S, Gout I, Brickell PM, Levinsky RJ, Kinnon C, Lovering RC (Nov 1996). "Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways". Journal of Immunology. 157 (9): 3791–5. PMID 8892607.
  • Takahashi-Tezuka M, Hibi M, Fujitani Y, Fukada T, Yamaguchi T, Hirano T (May 1997). "Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK". Oncogene. 14 (19): 2273–82. doi:10.1038/sj.onc.1201071. PMID 9178903.
  • Laffargue M, Monnereau L, Tuech J, Ragab A, Ragab-Thomas J, Payrastre B, Raynal P, Chap H (Sep 1997). "Integrin-dependent tyrosine phoshorylation and cytoskeletal translocation of Tec in thrombin-activated platelets". Biochemical and Biophysical Research Communications. 238 (1): 247–51. doi:10.1006/bbrc.1997.7269. PMID 9299487.
  • Kitanaka A, Mano H, Conley ME, Campana D (Feb 1998). "Expression and activation of the nonreceptor tyrosine kinase Tec in human B cells". Blood. 91 (3): 940–8. PMID 9446655.
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